Seroprevalence of cytomegalovirus infection in France in 2010

Antona, Denise; Lepoutre, A.; Fonteneau, Laure; Baudon, Claire; Halftermeyer-Zhou, F.; Strat, Yann Le; Lévy-Brühl, Daniel

doi:10.1017/s0950268817000103

Cited by 44 publications

(37 citation statements)

References 38 publications

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“…Although these sera were collected in 1998, this population based CMV seroprevalence data are an important source for epidemiological modelling and they will serve as baseline data of longitudinal surveys in the future. In this study, 51% of men and 62% of women were positive for CMV-specific Ig; these data are comparable to seroprevalence data from France and the Netherlands [ 24 , 25 ]. In contrast, populations in Portugal (77%), Sweden (83%) and Croatia (77%) seem to have slightly higher CMV seroprevalence [ 26 – 28 ].…”

Section: Discussionsupporting

confidence: 88%

Cytomegalovirus (CMV) seroprevalence in the adult population of Germany

et al. 2018

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BackgroundInfection with cytomegalovirus (CMV) remains asymptomatic in most immunocompetent hosts, but is the leading cause of congenital viral infection worldwide and can be life-threatening in immunocompromised individuals. We aimed to assess CMV seroprevalence in a nationally representative sample of adults in Germany and to identify sociodemographic factors associated with CMV seropositivity.MethodsBlood samples from 6552 participants (18–79 years) of the “German National Health Interview and Examination Survey 1998”, a population-based sample of the adult population in Germany, were tested for the presence of CMV antibodies using an Ig-multiplex assay. Weighted seroprevalence was calculated and weighted binomial regression was used to identify factors associated with CMV seropositivity.ResultsOverall CMV seroprevalence was 56.7% (95%CI: 54.8–58.7%), with a higher seroprevalence in women (62.3%) than in men (51.0%). Seroprevalence increased with age: from 31.8% to 63.7% in men and from 44.1% to 77.6% in women when comparing the 18–29 with the 70–79 year age-group, respectively. CMV seroprevalence in women of childbearing age (18–45 years) was 51.7%. Factors significantly associated with CMV seropositivity were age, country of birth, smoking status, education, living in northern Germany and number of household members. In addition, having attended child care was associated with seropositivity in men, and number of siblings and living in East Germany in women.ConclusionOur results indicate that half the women of childbearing age were susceptible for primary CMV infection during pregnancy. CMV screening during pregnancy and informing seronegative women about CMV risk reduction measures could prevent congenital CMV infections with its serious consequences.

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Section: Discussionsupporting

confidence: 88%

Cytomegalovirus (CMV) seroprevalence in the adult population of Germany

et al. 2018

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“…C ytomegalovirus (CMV) infection is endemic worldwide, with a 30-61% seroprevalence in developed countries (1,24) and 60-100% seroprevalence in developing countries (26,31,38). CMV infection is usually acquired early in life resulting in an asymptomatic, subclinical, and mostly latent infection in immune-competent persons.…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of Cytomegalovirus Infection Among HIV-Infected and HIV-Uninfected Pregnant Women Attending Antenatal Clinic in Harare, Zimbabwe

et al. 2019

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This study aimed to investigate the seroprevalence of cytomegalovirus (CMV) infection and risk factors associated with CMV acquisition among pregnant women in Zimbabwe. In a cross-sectional study, pregnant women were recruited in late gestation, seeking antenatal care at council clinics in three high-density suburbs in Harare, Zimbabwe. Anti-CMV IgM and IgG antibodies were quantified in serum using an enzyme-linked immunosorbent assay. Antibody avidity tests were used to distinguish active infection from viral reactivation in anti-CMV IgM-positive cases. Five hundred and twenty four women were recruited: 278 HIV infected and 246 HIV uninfected. Current or active CMV infection defined as IgM positive+low avidity was detected in 4.6% (24/524), 95% confidence interval (CI): 3–6.9 in all women, 5.8% (16/278) in the HIV infected and 3.3% (8/246), 95% CI: 1.4–6.3 in the HIV uninfected. IgG seroprevalence was 99.6% (522/524), 95% CI: 98.6–99.9 in all women. Notably, the difference in the prevalence of active CMV infection between the HIV-infected and HIV-uninfected women was not statistically significant (p = 0.173). The study shows a low prevalence of primary or active CMV infection among the pregnant women, but the IgG seroprevalence suggests high previous CMV exposure. Importantly, CMV seroprevalence was not associated with the HIV status of the women, perhaps due to the ubiquitous exposure of the population to CMV.

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“…Depending on the country and its state of development, 25–90% of the worldwide population is CMV seropositive (2, 3) with prevalence higher in older adults (4). Once infected with CMV, the immune system is unable to eliminate the virus, resulting in persistent latent infection.…”

Section: Introductionmentioning

confidence: 99%

Impact of Aging and Cytomegalovirus on Immunological Response to Influenza Vaccination and Infection

et al. 2017

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The number of people over the age of 60 is expected to double by 2050 according to the WHO. This emphasizes the need to ensure optimized resilience to health stressors in late life. In older adults, influenza is one of the leading causes of catastrophic disability (defined as the loss of independence in daily living and self-care activities). Influenza vaccination is generally perceived to be less protective in older adults, with some studies suggesting that the humoral immune response to the vaccine is further impaired in cytomegalovirus (CMV)-seropositive older people. CMV is a β-herpes virus infection that is generally asymptomatic in healthy individuals. The majority of older adults possess serum antibodies against the virus indicating latent infection. Age-related changes in T-cell-mediated immunity are augmented by CMV infection and may be associated with more serious complications of influenza infection. This review focuses on the impact of aging and CMV on immune cell function, the response to influenza infection and vaccination, and how the current understanding of aging and CMV can be used to design a more effective influenza vaccine for older adults. It is anticipated that efforts in this field will address the public health need for improved protection against influenza in older adults, particularly with regard to the serious complications leading to loss of independence.

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Seroprevalence of cytomegalovirus infection in France in 2010

Cited by 44 publications

References 38 publications

Cytomegalovirus (CMV) seroprevalence in the adult population of Germany

Cytomegalovirus (CMV) seroprevalence in the adult population of Germany

Seroprevalence of Cytomegalovirus Infection Among HIV-Infected and HIV-Uninfected Pregnant Women Attending Antenatal Clinic in Harare, Zimbabwe

Impact of Aging and Cytomegalovirus on Immunological Response to Influenza Vaccination and Infection

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