Cytomegalovirus Seroprevalence Among Solid Organ Donors in Hungary: Correlations With Age, Gender, and Blood Group

Varga, Marina; Görög, Dénes; Debbink, Kari; Környei, E.; Kis, Éva; Túryné, H.J.; Jankovics, István; Péter, Antal; Toronyi, É.; Sárváry, Enikő; Fazakas, János; Reusz, György

doi:10.1016/j.transproceed.2011.03.067

Cited by 21 publications

(18 citation statements)

References 5 publications

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“…The only exception to this trend was observed in children less than 6 months who had high prevalence (84.4%) reflecting transient presence of transplacentally derived maternal IgG antibodies. Similar results were found in majority other studies [10,15,18,19,33]. Comparing seroprevalence in the similar age groups, some differences were found in children and adolescents.…”

Section: Discussionsupporting

confidence: 91%

“…In the general population, seroprevalence in Croatia is comparable to that of Portugal (77%) [14]. Lower prevalence rates were reported in the Netherlands (45.6%) [19], France (49.5%) 7 [18], Germany (57.25%) [17] and Spain (62.8%) [30], while Hungary, Turkey and Russia showed higher seroprevalence rates (86% and 80.9-94.8%, respectively) [10,13,15,16].…”

Section: Discussionmentioning

confidence: 99%

“…Immunocompromised individuals such as HIV-infected patients, hemodialysis patients and transplant recipients may develop severe CMV disease with a wide spectrum of clinical symptoms including retinitis, hepatitis, colitis, pancreatitis, pneumonitis and encephalitis [8][9][10]. In addition, pregnant women also represent a risk-group for CMV infection.…”

Section: Introductionmentioning

confidence: 99%

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Seroepidemiology of cytomegalovirus infections in Croatia

Vilibić-Čavlek

Kolarić

Beader

et al. 2016

Wien Klin Wochenschr

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Objectives: Cytomegalovirus (CMV) is endemic worldwide, with marked differences in the seroprevalence rates between countries. The aim of this study was to analyze the seroprevalence of CMV infection in Croatia. Methods:During a three year period (2013)(2014)(2015), 2438 consecutive serum samples collected from Croatian residents were tested for the presence of CMV IgM and IgG antibodies using enzyme-linked immunoassay. IgM/IgG positive samples were further tested for IgG avidity. Results:The overall seroprevalence rates for CMV IgG and IgM antibodies were 74.4% and 4.3%, respectively. The IgG seroprevalence differed significantly between population groups: children/adolescents 54.6%, adult general population 77.2%, hemodialysis patients 91.4% (p<0.001). CMV seropositivity was strongly age-dependent with prevalence ranging from 53.0% in children less than 10 years to 93.8% in persons above 60 years (p<0.001). There was no difference in the prevalence between women with normal pregnancy and women with bad obstetric history. Gender and place of residence was not associated with CMV seropositivity.Using IgG avidity, current/recent primary CMV infection was confirmed by low/borderline avidity index (AI) in 46.7% participants, while in 53.3% high AI indicated CMV reactivation or reinfection. Primary infections were detected mainly in children and adolescents (83.2% and 70.5%), while reactivations/reinfections were common in persons older than 40 (77.0-100%). Reactivations/reinfections were most commonly detected in hemodialysis patients (92.3%). Logistic regression showed that older age and being on hemodialysis were significant predictors of CMV seropositivity.Conclusions: CMV is widespread in the Croatian population. Older age and being on hemodialysis appeared to be main risk factors for CMV infection.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Seroepidemiology of cytomegalovirus infections in Croatia

Vilibić-Čavlek

Kolarić

Beader

et al. 2016

Wien Klin Wochenschr

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“…Without antiviral prophylaxis the majority of renal transplant patients would develop CMV infections (5–7). The high seroprevalence of CMV makes reactivation from latency more frequent than de novo infections (8,9).…”

Section: Introductionmentioning

confidence: 99%

“…Without antiviral prophylaxis the majority of renal transplant patients would develop CMV infections (5)(6)(7). The high seroprevalence of CMV makes reactivation from latency more frequent than de novo infections (8,9). CMV displays a broad target cell tropism including epithelial cells, endothelial cells, fibroblasts and different hematopoietic cells (10,11).…”

Section: Introductionmentioning

confidence: 99%

CMV Late Phase-Induced mTOR Activation Is Essential for Efficient Virus Replication in Polarized Human Macrophages

Poglitsch

Weichhart

Hecking

et al. 2012

American Journal of Transplantation

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Area-Level Social Deprivation and Cytomegalovirus Seropositivity at the Time of Solid Organ Transplant

Abidi,

Lopez,

Arrigain

et al. 2024

JAMA Netw Open

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ImportanceCytomegalovirus (CMV) is associated with significant morbidity and mortality in solid organ transplant (SOT) recipients. The risk factors for CMV seropositivity in SOT recipients, including area-level social deprivation in the US, have not been fully characterized.ObjectiveTo (1) evaluate CMV seroprevalence, (2) assess the recipient characteristics associated with CMV seropositivity, and (3) assess the association of area-level social deprivation index (SDI) scores with pretransplant CMV serostatus.Design, Setting, and ParticipantsThis retrospective cross-sectional analysis of the Scientific Registry of Transplant Recipients database included all adult (aged ≥18 years) SOT recipients from January 1, 2008, to May 31, 2022. Data were analyzed from April 10 to October 25, 2023.ExposureRecipient characteristics and area-level SDI.Main Outcomes and MeasuresMultivariable generalized linear models were used to evaluate the association between (1) patient characteristics and CMV and (2) social deprivation (measured by SDI scores, which were assessed in quintiles, from lowest to highest) and CMV seropositivity. In addition, differences based on patient demographics and the transplanted organ(s) were evaluated.ResultsAmong the 389 288 SOT recipients included in the analysis, mean (SD) age was 53.3 (13.0) years; 63.0% were male, 21.4% were Black, 15.2% were Hispanic White, 56.2% were non-Hispanic White, and 62.7% were CMV seropositive. The mean (SD) age was higher among CMV seropositive (54.0 [12.7] years) compared with CMV seronegative (52.0 [13.5] years) patients. Seropositivity for CMV was higher among women (69.9%) than men (58.5%) and among Black (74.8%) and Hispanic White (80.2%) patients compared with non-Hispanic White patients (50.4%). Seropositivity for CMV was highest among kidney (64.5%), liver (63.6%), and kidney and liver (66.2%) recipients. Greater SDI scores were associated with greater CMV seropositivity, ranging from 51.7% for the least deprived to 75.5% for the most deprived quintiles (P &lt; .001), independent of age, sex, or race.Conclusions and RelevanceIn this cross-sectional study, an association between SDI and CMV seropositivity was observed among SOT recipients, independent of age, sex, or race and ethnicity. To optimize posttransplant outcomes in CMV seropositive recipients, efforts targeting prevention of CMV reactivation need to be prioritized in these higher-risk populations.

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Cytomegalovirus Seroprevalence Among Solid Organ Donors in Hungary: Correlations With Age, Gender, and Blood Group

Cited by 21 publications

References 5 publications

Seroepidemiology of cytomegalovirus infections in Croatia

Seroepidemiology of cytomegalovirus infections in Croatia

CMV Late Phase-Induced mTOR Activation Is Essential for Efficient Virus Replication in Polarized Human Macrophages

Area-Level Social Deprivation and Cytomegalovirus Seropositivity at the Time of Solid Organ Transplant

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