Cytomegalovirus Pneumonia Mimicking Lung Cancer in an Immunocompetent Host

Karakelides, Helen; Aubry, Marie Christine; Ryu, Jay H.

doi:10.4065/78.4.488

Cited by 35 publications

(16 citation statements)

References 15 publications

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“…Although no immunostaining for herpes was performed in this case, the lesion showed remarkable improvement with acyclovir therapy. Endobronchial masses simulating neoplasm have also been reported with cytomegalovirus, mycobacterium species and mucormycosis [17][18][19]. The endobronchial mass of the patient presented here may have resulted from extensive necrosis with formation of abundant granulation tissue in the subepithelial zone, as a reaction to epithelial inflammation.…”

Section: Discussionmentioning

confidence: 90%

Endobronchial pseudo-tumour caused by herpes simplex

Upadya

Tilluckdharry²,

Nagy³

et al. 2005

European Respiratory Journal

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Herpes simplex virus (HSV) causes tracheobronchitis and pneumonitis; however, to date, there has only been one report of an endobronchial mass caused by HSV type II.This case study describes a 68-yr-old female with severe kyphoscoliosis who was intubated for acute on chronic hypercapnic respiratory failure and developed blood-tinged endotracheal secretions.Fibreoptic bronchoscopy demonstrated an endobronchial mass in the right middle lobe. Cultures grew HSV type I and biopsy specimens demonstrated cytopathological changes consistent with HSV infection. This is the first reported case of HSV type I presenting as an endobronchial tumour.

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Section: Discussionmentioning

confidence: 90%

Endobronchial pseudo-tumour caused by herpes simplex

Upadya

Tilluckdharry²,

Nagy³

et al. 2005

European Respiratory Journal

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“…Radiation-primed organising pneumonia is thus quite similar to COP. Interestingly, this peculiar iatrogenic organising pneumonia provides some insight into the pathogenesis of Chlamydia pneumoniae [184,185] Coxiella burnetii [186,187] Legionella pneumophila [95,[188][189][190][191][192][193][194] Mycoplasma pneumoniae [95,189,[195][196][197] Nocardia asteroides [198,199] Pseudomonas aeruginosa [200] Serratia marcescens [201]; in lung transplant recipient [200] Staphylococcus aureus In lung transplant recipient [200] Streptococcus pneumoniae [5,6,202] Viruses Adenovirus [203] Cytomegalovirus [203,204] Herpes virus In lung transplant recipient [200] HIV [205][206][207][208][209][210]; in a pregnant patient using cocaine [205]; following highly active antiretroviral therapy introduction [211] Influenza virus [189,[212][213][214] Parainfluenza virus [215] Human herpes virus-7 …”

Section: Determined Causes Of Organising Pneumoniamentioning

confidence: 99%

Cryptogenic organising pneumonia

Jf¹

2006

European Respiratory Journal

472

466

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Organising pneumonia is defined histopathologically by intra-alveolar buds of granulation tissue, consisting of intermixed myofibroblasts and connective tissue. Although nonspecific, this histopathological pattern, together with characteristic clinical and imaging features, defines cryptogenic organising pneumonia when no cause or peculiar underlying context is found. Rapid clinical and imaging improvement is obtained with corticosteroid treatment, but relapses are common after stopping treatment.

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“…In this case, CMV pneumonitis was diagnosed by PCR of BALF and transbronchial lung biopsy samples and was ameliorated by ganciclovir. Karakelides et al [7] reported an immunocompetent host with CMV pneumonitis that formed a cavitary lesion similar to a lung cancer. In this case, the patient was a smoker, but not an immunocompromised host.…”

Section: Discussionmentioning

confidence: 98%

Cavitary lung lesion in a patient with systemic lupus erythematosus: an unusual manifestation of cytomegalovirus pneumonitis

et al. 2008

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We report a 35-year-old female patient with systemic lupus erythematosus (SLE). She was admitted due to deterioration of lupus nephritis and received treatment with a high dose of steroid and cyclosporine. Approximately 1 month after admission, the patient was also treated for cytomegalovirus (CMV) infection because she was found to have CMV antigenemia. Although a cavitary lesion was shown by chest computed tomography (CT), its cause could not be clarified by blood examination, smears or cultures, or by bronchoscopy. We considered that this lesion may have been caused by CMV pneumonitis because it was resolved during the treatment for CMV infection. It is known that CMV causes opportunistic infections in patients with collagen vascular diseases (CVD) who are receiving immunosuppressive therapy. However, it is extremely rare for a cavitary lesion to be formed as a result of CMV pneumonitis. Here we describe the details of this interesting case.

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Cytomegalovirus Pneumonia Mimicking Lung Cancer in an Immunocompetent Host

Cited by 35 publications

References 15 publications

Endobronchial pseudo-tumour caused by herpes simplex

Endobronchial pseudo-tumour caused by herpes simplex

Cryptogenic organising pneumonia

Cavitary lung lesion in a patient with systemic lupus erythematosus: an unusual manifestation of cytomegalovirus pneumonitis

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