Cytomegalovirus Infection of the Gastrointestinal Tract in A Patient with Late Onset Immunodeficiency Syndrome

Freeman, Hugh James; Shnitka, T. K.; Piercey, J.; Weinstein, Wilfred M.

doi:10.1016/s0016-5085(19)31521-5

Cited by 58 publications

(12 citation statements)

References 21 publications

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“…Thus far, prognosis has been serious when cytomegalovirus of the colon has been documented in ulcerative colitis. Nine of 12 Infecti on of the colon with cytomegalovirus has rarelybeen verified histologically. When it has occurred in association with ulcerative colitis,1' five of 11 patients have died.…”

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confidence: 99%

Cytomegalovirus Infection of the Colon Associated With Ulcerative Colitis

Sidi¹

1979

Arch Surg

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confidence: 99%

Cytomegalovirus Infection of the Colon Associated With Ulcerative Colitis

Sidi¹

1979

Arch Surg

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“…In contrast, in immunocompromised patients, CMV infections can severely affect the organs, leading to multiorgan failure. Hence, severe or apparent CMV diseases most often occur in patients with an impaired immune system, e.g., patients with human immunodeficiency virus (HIV)/AIDS, patients under immunosuppression after organ transplantation, or patients undergoing chemotherapy for malignancies .…”

Section: Discussionmentioning

confidence: 99%

Cytomegalovirus infection of the major duodenal papilla in a renal allograft recipient with severe biliary obstruction and acalculous cholecystitis

Riediger

Beimler

Weitz

et al. 2013

Transplant Infectious Dis

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Cytomegalovirus (CMV) can cause severe infections with serious consequences in renal transplant recipients. Disseminated CMV infections can affect almost every organ, but obstructive cholestasis and cholangitis, as a consequence of a CMV-induced papillitis, is extremely rare. We are reporting a rare case of obstructive cholestasis and cholecystitis due to CMV-related inflammation of the major duodenal papilla in a 60-year-old woman 3 months after renal transplantation. In addition, the patient suffered from a disseminated CMV infection with ulcerative esophagitis and gastritis. Because of the severe CMV infection, failure of the renal graft occurred. Obstructive cholestasis was resolved through internal stenting, and the progressive cholecystitis necessitated an emergency cholecystectomy. Following antiviral therapy with ganciclovir, the gastrointestinal ulcerations regressed and renal function was restored. Diagnosis of the CMV-related disease was established only in tissue samples, whereas standard serologic tests had failed.

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“…The frequency of reactivated herpes zoster attacks is higher than normal in patients with CVID, developing in ∼20% of patients [23,24]. Severe cytomegalovirus infections of the gastrointestinal tract have also been reported in a small number of patients [25]. CVID patients are highly susceptible to enteric infections [18] (Salmonella, Shigella, Campylobacter, rotavirus, chronic Giardia lamblia infections).…”

Section: Discussionmentioning

confidence: 99%