Cytomegalic inclusion disease and ulcerative colitis

Powell, Robin D.; Warner, Nicholas P.; Levine, Robert S.; Kirsner, Joseph B.

doi:10.1016/0002-9343(61)90105-x

Cited by 139 publications

(64 citation statements)

References 17 publications

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“…Since 1961, many authors have reported an association of CMV infection with ulcerative colitis 11,14 . However, the frequency of this association remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Cytomegalovirus in colorectal cancer and idiopathic ulcerative colitis

Mariguela

Chachá

Cunha

et al. 2008

Rev. Inst. Med. trop. S. Paulo

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SUMMARYCytomegalovirus (CMV) is a genus in the family Herpesviridae that has been associated with gastrointestinal syndromes. In this work we looked for a possible association of CMV infection with colorectal cancer and ulcerative colitis (UC). Blood and enteric tissue samples of 14 patients with colorectal cancer and of 21 with UC were subjected to a nested-PCR that amplifies part of the gB gene of CMV and also to immunohistochemistry using a specific monoclonal antibody to IE 76kDa protein of CMV. CMV was detected by nested-PCR in the blood and/or the enteric tissue of nine (64.3%) colorectal cancer and 16 (76.2%) ulcerative colitis patients. In the immunohistochemistry it was observed that 12 (12/21, 57.1%) positive enteric tissue samples of patients with UC and none from patients with colorectal cancer (0/14) were positive to CMV. The positivity of CMV infections in the UC patient group (12/21, 57.1%) showed by both techniques, was significantly higher (p = 0.015) than that observed for colorectal cancer patients (2/14, 14.3%). These results suggest an association of ulcerative colitis with CMV infection of the enteric tissue.

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“…Since 1961, many authors have reported an association of CMV infection with ulcerative colitis 11,14 . However, the frequency of this association remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Cytomegalovirus in colorectal cancer and idiopathic ulcerative colitis

Mariguela

Chachá

Cunha

et al. 2008

Rev. Inst. Med. trop. S. Paulo

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“…The clinical outcome of IBD with superimposed CMV is not well understood. The first report about the possible role of cytomegalovirus in IBD dates to 1961 when Powell [31] described a case of ulcerative colitis and cytomegalic inclusion disease. After many sporadic reports over the last decade, the topic has regained attention due to more frequent publications of case-reports or small series studies in which the virus provided a worsening prognosis influence, sometimes promoting disease initiation or otherwise acting as a bystander [9] .…”

Section: And Acquired Immunodeficiency Syndromes or Immunosuppresmentioning

confidence: 99%

“…Since gross appearance is nonspecific, a diagnosis is based on the histopathological identification of viral-infected cells in biopsied tissues, using appropriate staining Haematoxylin and Eosin (HE), Immunohistochemistry (ICH), by a dedicated pathologist. Cytomegalic cells have been revealed that are 2-or 4 fold larger (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) µm) than surrounding cells, containing a basophilic intranuclear inclusion (8-10 µm) that is eccentrically placed and is sometimes surrounded by a clear halo, giving it an "owl's eye" appearance. These cells also show a thickened nuclear membrane, frequently associated with smaller granular intracytoplasmatic inclusions.…”

Section: Introductionmentioning

confidence: 99%

Cytomegalovirus and inflammatory bowel disease: Is there a link?

Criscuoli¹,

Rizzuto²,

Cottone³

2006

WJG

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The objective of this report is to give an overall view of the epidemiological, clinical, diagnostic and therapeutic features of Cytomegalovirus (CMV) infection in inflammatory bowel disease (IBD). A review of published reports on this topic was carried out, with particular attention paid to the selection of patients included in studies and the diagnostic methods employed. CMV is frequently associated with IBD. In some cases, CMV infection is associated with a poor outcome but it is not clear which patients are more likely to be affected and in which stage of the disease. The use of anti-viral therapy in IBD is controversial and an empirical study with controls is needed. The natural history of CMV infection related to the development and treatment of IBD has not been clarified but it is important to take it in consideration because of the possibility of viral persistence in the immunocompromised host and viral interaction with the immune system. family, which includes Epstein -Barr virus (EBV), Herpes Simplex virus tipes1 and 2 (HSV-1,2), Varicella-Zoster virus, and Human Herpes virus types 6 and 7 (HHV-6,7). Similar to infection with other viruses in the family, primary infection with CMV results in the establishment of a persistent or latent infection, due to the ability of the virus to remain integrated in the DNA of host cells. The sign of a viral infection is a cytopathic effect shown by the presence of large nuclear and cytoplasmic inclusions, represented by aggregates of replicating CMV nucleoprotein cores. To avoid recognition and destruction by CD8+T lymphocytes, the virus develops the ability to evade the immune system by several mechanisms. CMV produces some proteins, such as US2, US3 and US11, that inhibit the presentation of viral antigens to T cells, blocking the class I MHC in the endoplasmic reticulum or in the cytosol. It also produces homologues to class I MHC proteins and may compete for binding and presentation of viral antigens. Once the viral DNA remains undisturbed in the infected cells, subsequent reactivation can occur in response to several stimuli, such as immunosuppressant therapy or chemotherapy [1] . The down-regulation of the cell surface markers acts on interferon-alpha/beta dependent responses by affecting several levels of IFN signal transduction and a transcription activation pathway. CMV infection leads to the activation of Nuclear Factor kappa B (NF-kB) and its translocation to the nucleus, promoting the expression of cytokines, chemokines and cellular adhesion molecules. These mechanisms are also present in inflammatory bowel disease (IBD) where there is activation of several pro-inflammatory cytokines (such as IFN-gamma), the transcription of which is regulated through nuclear transcription factors (such as Nuclear Factor kappa B) and through a signal transducer and activator of transcription (STAT family). CMV aND IBDThe role of CMV in IBD is reviewed considering the following issues: diagnostic methods to detect the virus, prevalence of CMV in IBD according to pa...

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“…The exact pathogenic role of cytomegalovirus in these patients remains unclear despite a great number of published reports. Powell et al [12] first reported the association of cytomegalovirus with ulcerative colitis in 1961. CMV infection in ulcerative colitis patients, especially in those who are immune-compromised by steroid therapy, can produce severe systemic disease and often leads to colectomy, but the coincidental diagnosis of UC and CMV colitis has also been reported [13][14][15][16].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Cytomegalovirus Infection in Patients With Ulcerative Colitis by Using PCR Technique

Mehrabani-Khasraghi

Ameli

Khalily³

et al. 2015

Zahedan J Res Med Sci

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Background: Ulcerative colitis is one type of inflammatory bowel disease. Objectives: The aim of this study was to investigate the prevalence of cytomegalovirus in patients with ulcerative colitis in comparison with healthy subjects by using PCR technique. Patients and Methods:In this analytical case-control study, 5 patients with ulcerative colitis and 30 patients without malignancy as controls were selected. Biopsy specimens were frozen under sterile conditions at -20ºC. After DNA extraction, analysis of polymerase chain reaction (PCR) to detect CMV DNA in tissue samples was performed. Statistical analysis was performed with χ2 test. Results: CMV DNA was found in 80% of ulcerative colitis samples (4 of 5) and 30% of the non-malignant control group (9 of 30). Statistical analysis showed significant association between the prevalence of CMV and incidence ulcerative colitis in comparison with the control group (P = 0.03). Conclusions:The results of the present study has shown ulcerative colitis patients have a predisposition to CMV infection as compared to healthy individuals, but the etiologic link between ulcerative colitis and CMV infection needs to be studied.

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Cytomegalic inclusion disease and ulcerative colitis

Cited by 139 publications

References 17 publications

Cytomegalovirus in colorectal cancer and idiopathic ulcerative colitis

Cytomegalovirus in colorectal cancer and idiopathic ulcerative colitis

Cytomegalovirus and inflammatory bowel disease: Is there a link?

Prevalence of Cytomegalovirus Infection in Patients With Ulcerative Colitis by Using PCR Technique

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