Cytology of thecerebrospinal fluid in children with acute lymphoblastic leukemia

Aronson, A. Stefan; Garwicz, Stanislaw; Sörnäs, Rune

doi:10.1016/s0022-3476(74)80397-5

Cited by 5 publications

(3 citation statements)

References 7 publications

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“…The morphologic criteria for diagnosing these neoplasms have been well-defined. [1][2][3][4][5] Primary neoplasms, accounting for approximately two-thirds of all tumors occurring in the CNS, are only occasionally encountered in the CSF because of their frequent location within the CNS parenchyma. Therefore, there are only a few reports dealing specifically with the cytology of primary CNS tumors.…”

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confidence: 99%

Cytology of primary central nervous system neoplasms in cerebrospinal fluid specimens

Chhieng

Elgert

Cohen

et al. 2002

Diagnostic Cytopathology

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Although two-thirds of tumors occurring in the central nervous system (CNS) are primary neoplasms, only 10% of positive cerebrospinal fluid (CSF) specimens are from primary CNS tumors. In this study, we reviewed the cytologic findings of 21 positive CSF specimens from primary CNS tumors. A computer search identified 21 cases of positive CSF specimens from patients with primary CNS tumors from the archives. Follow-up included review of medical charts and histologic correlation. The specimens were from 20 patients (9 females and 11 males). Their ages ranged from 6-83 yr, old with a mean of 30 yr. The cases included 9 medulloblastomas, 7 gliomas (3 glioblastoma multiformes, 2 anaplastic astrocytomas, and 2 ependymomas), 2 germinomas, 2 non-Hodgkin's large B-cell lymphomas, and 1 ganglioneurocytoma. Two cases were classified as suspicious and the remaining as positive for malignancy. Immunocytochemistry was employed in 3 cases to support the cytologic diagnosis. These cases included one large-cell lymphoma (leukocyte-common antigen-positive), one germinoma (placental alkaline phosphatase-positive), and the ganglioneurocytoma (neuron-specific enolase- and synaptophysin-positive). There were no false-positive cases. Our results suggest that positive CSF cytology in patients with a primary CNS tumor is a reliable indicator of malignancy and reflects leptomeningeal involvement. The use of immunocytochemistry is helpful in confirming the cytologic impression in some cases.

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Cytology of primary central nervous system neoplasms in cerebrospinal fluid specimens

Chhieng

Elgert

Cohen

et al. 2002

Diagnostic Cytopathology

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“…We apply Permount to a clean cut edge of rubber tube and then compress the edge of the tubing to the glass. Results and discussion After evaluation and comparison of many different methods, Sornas developed and recommended the sedimentation method for cytology of CSF (S6rnas, 1967;Aronson et al, 1974). The cytocentrifuge method has also been recommended recently by a few investigators (Drewinko et al, 1973;Evans et al, 1974).…”

Section: Methodsmentioning

confidence: 99%

“…However, it is not easy to prepare a good smear because the cells are easily lysed after a short period and also are easily damaged by centrifugation, fixation, and concentration (S6rnas, 1967). The sedimentation method of S6rnas appears to be a much better method for both cell recovery and morphology (Sornas, 1967;Aronson et al, 1974). We have de-Address for correspondence and reprints:…”

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Simple method for the cytological examination of cerebrospinal fluid.

Chu¹,

Freiling²,

Wassilak³

1977

J Clin Pathol

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Sedimentation versus cytocentrifugation in the cytologic study of craniospinal fluid

Ducos

Donoso

Weickhardt

et al. 1979

Cancer

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A sedimentation technique for cytologic study of CSF was compared with the standard cytocentrifugation method. Seventy-five samples from 37 children with leukemia and non-Hodgkin's lymphoma were processed by both methods. Total yield of cells and cytomorphology with differentials were analyzed. The techniques are comparable and both allow good cytologic study of the CSF even with very low cell counts/mm3. The sedimentation method can be used as an alternative, especially if a cytocentrifuge is not available. When both methods are used, the possibility of negative cell yield is decreased.

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Cytology of thecerebrospinal fluid in children with acute lymphoblastic leukemia

Cited by 5 publications

References 7 publications

Cytology of primary central nervous system neoplasms in cerebrospinal fluid specimens

Cytology of primary central nervous system neoplasms in cerebrospinal fluid specimens

Simple method for the cytological examination of cerebrospinal fluid.

Sedimentation versus cytocentrifugation in the cytologic study of craniospinal fluid

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