Cytology and arrangement of enterochromaffin(EC) cells in the human stomach.

Kusumoto, Yoshisuke; Grube, D.; Sato, Akinao; Kaneda, Kazufumi; Nakamae, Eihachiro

doi:10.1679/aohc.51.271

Cited by 7 publications

(8 citation statements)

References 13 publications

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“…However, some are of the closed type, having no clear access to lumenal contents. This lack of lumenal contact has been confirmed by serial section (Kusumoto et al, 1988). As these EE cells make contact with the lumen they may have a different role in chemosensory transduction.…”

Section: Ee Cells and Their Transmitters In Gi Sensory Transductionmentioning

confidence: 60%

The cornucopia of intestinal chemosensory transduction

Bertrand

2009

Front. Neurosci.

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The chemosensory transduction mechanisms that the gastrointestinal (GI) tract uses to detect chemical and nutrient stimuli are poorly understood. The GI tract is presented with a wide variety of stimuli including potentially harmful chemicals or toxins as well as ‘normal’ stimuli including nutrients, bacteria and mechanical forces. Sensory transduction is at its simplest the conversion of these stimuli into a neural code in afferent nerves. Much of the information encoded is used by the enteric nervous system to generate local reflexes while complementary information is sent to the central nervous system via afferents or by release of hormones to affect behaviour. This review focuses on the chemosensory transduction mechanisms present in the GI tract. It examines the expression and localisation of the machinery for chemosensory transduction. It summarises the types of cells which might be involved in detecting stimuli and releasing neuroactive transmitters. Finally, it highlights the idea that chemosensory transduction mechanisms in the GI tract utilise many overlapping and complementary mechanisms for detecting and transducing stimuli into reflex action.

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Section: Ee Cells and Their Transmitters In Gi Sensory Transductionmentioning

confidence: 60%

The cornucopia of intestinal chemosensory transduction

Bertrand

2009

Front. Neurosci.

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“…In man but not in rat, some endocrine cell types, including the ECL , D (Larsson, 1980), and EC (Inokuchi et al, 1984;Kusumoto et al, 1988) cells are provided with long cytoplasmic processes (Fig. 3,top left;Fig.…”

Section: Endocrine Cells Of Thementioning

confidence: 99%

“…3, bottom right) (D'Adda et al, 1989;Inokuchi et al, 1984;Kusumoto et al, 1988). Moreover, they may present a complex configuration with one or more cytoplasmic processes (Kusumoto et al, 1988), sometimes projecting into adjacent glands, thus suggesting a role for EC cells in functional synchronization among neighboring glands (Inokuchi et al, 1984).…”

Section: Ec Cellsmentioning

confidence: 99%

“…These cells share with their oxyntic counterpart the same granule morphology distinctive for the gastric sub-type of gastrointestinal EC cells. They are more frequent in the proximal antral mucosa and are rare near the pylorus (Kusumoto et al, 1988). Moreover, they are concentrated in the basal part of the mucosa, usually appearing as thin cells distended alongside the basal lamina of the bottom of the antral glands (Bordi et al, 1983;Kusumoto et al, 1988).…”

Section: Ec Cellsmentioning

confidence: 99%

“…Moreover, they are concentrated in the basal part of the mucosa, usually appearing as thin cells distended alongside the basal lamina of the bottom of the antral glands (Bordi et al, 1983;Kusumoto et al, 1988). Computer-assisted tridimensional reconstruction of these cells confirmed the absence of luminal extensions and showed their frequent contact with other EC cells, thus revealing a syncitium-like arrangement and suggesting synchronized function(s) of these cells (Kusumoto et al, 1988). The differences between oxyntic and antral EC cells with respect to their shape and spatial relationship with surrounding structures may be indicative of regional differences in their functions and, in particular, the elongated shape of antral EC cells (Fig.…”

Section: Ec Cellsmentioning

confidence: 99%

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Classification of gastric endocrine cells at the light and electron microscopical levels

Bordi

D’Adda

Azzoni

et al. 2000

Microsc. Res. Tech.

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This review discusses the current concepts for the classification of gastric endocrine cells subdivided according to the type of mucosa in which they are located. In the oxyntic mucosa, the most important cell type is the ECL cell, involved in the synthesis and secretion of histamine. Proteins involved in many aspects of the biology of ECL cells including the response to the gastrin stimulus, membrane transport and docking, prevention of apoptosis, calcium homeostasis, autocrine activity, and maintenance of the differentiated cell phenotype have been localized to this cell type. Other cells of the oxyntic mucosa include: the D and EC cells producing somatostatin and serotonin, respectively, delivered through long cell processes; the X (or A‐like) cells, possibly producing endothelin; and the D1 and P cells of unknown function and possibly representing morphological variants of other cell types. In the antral mucosa, the three important cell types are represented by: the gastrin‐producing G cells; the somatostatin‐producing D cells, which are anatomically and functionally associated with G cells; and the serotonin‐producing EC cells, which are located at the bottom of antral glands. Microsc. Res. Tech. 48:258–271, 2000 © 2000 Wiley‐Liss, Inc.

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Digestive Apparatus

Krstić

1991

Human Microscopic Anatomy

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Cytology and arrangement of enterochromaffin(EC) cells in the human stomach.

Cited by 7 publications

References 13 publications

The cornucopia of intestinal chemosensory transduction

The cornucopia of intestinal chemosensory transduction

Classification of gastric endocrine cells at the light and electron microscopical levels

Digestive Apparatus

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