Digestive Apparatus

Krstić, Radivoj V.

doi:10.1007/978-3-662-02676-2_7

Cited by 2 publications

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“…Binucleate parietal cells have been described in normal gastric mucosa in humans and domestic species. 14,28 Binucleate parietal cells were present in 49 of 50 animals; the 1 animal without binucleate parietal cells was the Goeldi's monkey neonate that had no identified IBs. In callitrichids, binucleate parietal cells appear to be an incidental finding and may increase with age.…”

Section: Discussionmentioning

confidence: 99%

“…13 Binucleate gastric parietal cells are a normal finding in humans and domestic animals. 14,28 Given that IBs and multinucleate epithelial cells can be manifestations of viral infections and other pathologic processes, knowledge of the occurrence of normal or incidental IBs and multinucleation is essential for accurate assessment of disease. Prior postmortem examinations of callitrichids submitted to the Anatomic Pathology Service at the University of Florida Veterinary Diagnostic Laboratories (APS-UF-VDL) had identified multinucleate parietal cells and cytoplasmic IBs in gastric epithelial cells.…”

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Multinucleate parietal cells and cytoplasmic inclusion bodies in the gastric epithelium of callitrichids

et al. 2021

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Inclusion bodies (IBs) and multinucleate cells can be associated with viral infections; however, IBs and multinucleate cells have been described in normal tissue and with non-viral disease processes in multiple species. We examined fundic stomach from 50 callitrichids histologically for bi- and multinucleate parietal cells and cytoplasmic IBs in gastric epithelial cells. Callitrichids represented included 6 genera: Saguinus (4 spp.), Leontopithecus (1 sp.), Mico (3 spp.), Cebuella (1 sp.), Callithrix (1 sp.), Callimico (1 sp.), and 13 unspecified marmosets. Gastric epithelial IBs were present in 46 of 47 (98%) of the callitrichids from which the stomach was sufficiently well preserved to identify IBs. Cytoplasmic IBs were identified in gastric surface pit epithelial cells (43 of 44, 98%), mucous neck cells (43 of 44, 98%), parietal cells (43 of 44, 98%), and chief cells (43 of 44, 98%). The IBs were eosinophilic, ovoid, round, elongate, or variably indented, sometimes slightly refractile, and 1–6 × 1–13 µm. IBs were sometimes perinuclear and molded around the nucleus. Electron microscopy of the gastric epithelium of one marmoset indicated that IBs were composed of intermediate filaments. The IBs did not stain with immunohistochemical markers for cytokeratin AE1/AE3 or vimentin. Binucleate parietal cells were found in 49 of 50 (98%) callitrichids, and multinucleate parietal cells were observed in 40 of 49 (82%) callitrichids. Gastric epithelial cytoplasmic IBs and bi- and multinucleate parietal cells are likely a normal finding in callitrichids, and, to our knowledge, have not been reported previously.

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Section: Discussionmentioning

confidence: 99%

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Multinucleate parietal cells and cytoplasmic inclusion bodies in the gastric epithelium of callitrichids

et al. 2021

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Transsinusoidal Portal Vein Embolization with Ethylene Vinyl Alcohol Copolymer (Onyx): A Feasibility Study in Pigs

Smits

Vanlangenhove

Sturm

et al. 2011

Cardiovasc Intervent Radiol

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PurposePortal vein embolization is performed to increase the future liver remnant before liver surgery in patients with liver malignancies. This study assesses the feasibility of a transsinusoidal approach for portal vein embolization (PVE) with the ethylene vinyl alcohol copolymer, Onyx.MethodsIndirect portography through contrast injection in the cranial mesenteric artery was performed in eight healthy pigs. Onyx was slowly injected through a microcatheter from a wedged position in the hepatic vein and advanced through the liver lobules into the portal system. The progression of Onyx was followed under fluoroscopy, and the extent of embolization was monitored by indirect portography. The pigs were euthanized immediately (n = 2), at 7 days (n = 4), or at 21 days postprocedure (n = 2). All pigs underwent necropsy and the ex vivo livers were grossly and histopathologically analyzed.ResultsTranssinusoidal PVE was successfully performed in five of eight pigs (63%). In 14 of 21 injections (67%), a segmental portal vein could be filled completely. A mean of 1.6 liver lobes per pig was embolized (range 1–2 lobes). There were no periprocedural adverse events. Focal capsular scarring was visible on the surface of two resected livers, yet the capsules remained intact. Histopathological examination showed no signs of recanalization or abscess formation. Mild inflammatory reaction to Onyx was observed in the perivascular parenchyma.ConclusionsThe porcine portal vein can be embolized through injection of Onyx from a wedged position in the hepatic vein. Possible complications of transsinusoidal PVE and the effect on contralateral hypertrophy need further study.

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Digestive Apparatus

Cited by 2 publications

References 99 publications

Multinucleate parietal cells and cytoplasmic inclusion bodies in the gastric epithelium of callitrichids

Multinucleate parietal cells and cytoplasmic inclusion bodies in the gastric epithelium of callitrichids

Transsinusoidal Portal Vein Embolization with Ethylene Vinyl Alcohol Copolymer (Onyx): A Feasibility Study in Pigs

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