Cytological Diagnosis of Aggressive Small-Cell Lymphomas

Caputo, Alessandro; Ciliberti, Valeria; Zeppa, Pio; D’Antonio, Antonio

doi:10.1159/000524270

Cited by 3 publications

(5 citation statements)

References 91 publications

(137 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More recent studies have indicated that FNAC can accurately diagnose lymphoma in 85-90% of patients, particularly when ancillary techniques complement morphological assessment [8,9]. Ancillary techniques, such as immunohistochemistry (IHC), can overcome these difficulties and support the interpretation of cytological diagnoses [10,11]. However, the role of FNAC in the initial diagnosis and subclassification of primary lymphoid malignancy remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Utility and Limitations of Fine-Needle Aspiration Cytology in the Diagnosis of Lymphadenopathy

Lee

Kim

et al. 2023

Diagnostics

View full text Add to dashboard Cite

Background: Fine needle aspiration cytology (FNAC) is a valuable tool for evaluating lymphadenopathy. The purpose of this study was to assess the reliability and effectiveness of FNAC in the diagnosis of lymphadenopathy. Methods: Cytological characteristics were evaluated in 432 patients who underwent lymph node FNAC and follow-up biopsy at the Korea Cancer Center Hospital from January 2015 to December 2019. Results: Fifteen (3.5%) of the four hundred and thirty-two patients were diagnosed as inadequate by FNAC, with five (33.3%) of these diagnosed as metastatic carcinoma on histological examination. Of the 432 patients, 155 (35.9%) were diagnosed as benign by FNAC, with seven (4.5%) of these diagnosed histologically as metastatic carcinoma. A review of the FNAC slides, however, showed no evidence of cancer cells, suggesting that the negative results may have been due to FNAC sampling errors. An additional five samples regarded as benign on FNAC were diagnosed as non-Hodgkin lymphoma (NHL) by histological examination. Of the 432 patients, 223 (51.6%) were cytologically diagnosed as malignant, with 20 (9.0%) of these diagnosed as tissue insufficient for diagnosis (TIFD) or benign on histological examination. A review of the FNAC slides of these 20 patients, however, showed that 17 (85.0%) were positive for malignant cells. The sensitivity, specificity, positive predictive value (PPV), negative predictive values (NPV), and accuracy of FNAC were 97.8%, 97.5%, 98.7%, 96.0%, and 97.7%, respectively. Conclusions: Preoperative FNAC was safe, practical, and effective in the early diagnosis of lymphadenopathy. This method, however, had limitations in some diagnoses, suggesting that additional attempts may be required according to the clinical situation.

show abstract

Section: Introductionmentioning

confidence: 99%

Utility and Limitations of Fine-Needle Aspiration Cytology in the Diagnosis of Lymphadenopathy

Lee

Kim

et al. 2023

Diagnostics

View full text Add to dashboard Cite

show abstract

“…Fine needle aspiration cytology (FNAC) is a rapid, safe, minimally invasive and highly accurate diagnostic tool for evaluating benign and malignant conditions 1–8 in various superficial and deep‐seated organs, including lymph nodes 9–12 . The incorporation of rapid on‐site evaluation (ROSE) further enhances its utility by gauging sample adequacy, leading to a notable decrease of approximately 20% in inadequate rates 4,13 .…”

Section: Introductionmentioning

confidence: 99%

“…Fine needle aspiration cytology (FNAC) is a rapid, safe, minimally invasive and highly accurate diagnostic tool for evaluating benign and malignant conditions [1][2][3][4][5][6][7][8] in various superficial and deep-seated organs, including lymph nodes. [9][10][11][12] The incorporation of rapid onsite evaluation (ROSE) further enhances its utility by gauging sample adequacy, leading to a notable decrease of approximately 20% in inadequate rates. 4,13 The precision of FNAC's diagnostic outcomes is augmented through immunocytochemistry (ICC) on diverse substrates such as cell block (CB), liquid-based cytology (LBC) or smears, along with molecular testing, [14][15][16][17] and flow cytometry (FC) for lymphoproliferative processes.…”

Section: Introductionmentioning

confidence: 99%

Combined fine needle aspiration cytology and core needle biopsy in the same setting: A two‐years’ experience

Ciliberti,

Maffei,

D'Ardia

et al. 2023

Cytopathology

Self Cite

View full text Add to dashboard Cite

IntroductionFine needle aspiration cytology (FNAC) combined with rapid on‐site evaluation (ROSE) and ancillary techniques is an accurate diagnostic tool for many pathologies. However, in some cases, it may not be sufficient for actionable diagnoses or molecular testing, especially for cases that require large immunohistochemical panels or cases in which histological features are mandatory for the diagnosis. Core needle biopsy (CNB), on the contrary, provides samples that are suitable for histological features and sufficient for all ancillary studies. However, CNB is often performed by radiologists or clinicians without the direct participation of cytopathologists, which can lead to missed or delayed diagnoses. This study reports on the experience of combining FNAC and CNB performed in one setting by cytopathologists. The aim was to evaluate the impact of CNB on FNAC and the diagnostic efficiency of the combined procedures.Materials and MethodsOne hundred forty‐two FNAC and CNB procedures performed in the same setting over a period of 2 years were analysed. The FNAC diagnoses were compared and integrated with the subsequent CNB diagnoses. The impact of CNB was categorized as follows: non‐contributory, in cases of inadequate samples; confirmed, when the CNB and FNAC diagnoses were the same; improved, when the CNB diagnosis was consistent with the FNAC diagnosis and further specified the corresponding entity; allowed, when CNB produced a diagnosis that could not be reached by FNAC; changed, when the CNB changed the previous FNAC diagnosis.ResultsCNB confirmed the FNAC diagnosis in 40.1% of cases (n = 57/142). CNB improved the FNAC diagnosis in 47.2% of cases (n = 67/142). CNB allowed a diagnosis that could not be performed on FNAC in 2.1% of cases (n = 3/142). CNB changed a previous FNAC diagnosis in 2.1% of cases (n = 3/142). CNB was non‐contributory in 8.4% of cases (n = 12/142). CNB produced a positive impact on the whole diagnostic procedure in 51.4% of total cases (n = 73/142). The combined FNAC and CNB resulted in actionable diagnoses in 91.5% of all cases (n = 130/142). A complete molecular assessment was successfully performed in 14.7% of cases (n = 21/142) utilizing either FNAC or CNB material.ConclusionsThe combined use of FNAC and CNB in one setting improves the diagnostic accuracy of both procedures. This approach exploits the advantages of each procedure, enhancing the accuracy of the final diagnosis.

show abstract

“…Molecular techniques and immunohistochemical techniques are important to further characterize cytomorphologically difficult cases diagnosed as lymphoproliferative disorders. 3 , 4 …”

Section: Introductionmentioning

confidence: 99%

“…Molecular techniques and immunohistochemical techniques are important to further characterize cytomorphologically difficult cases diagnosed as lymphoproliferative disorders. 3,4 FNAC technique was initially introduced in the early 1900's. 5 FNAC involves collecting cells by aspirating the affected organ or tissue using a thin needle to study them under a microscope after appropriate staining.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Fine Needle Aspiration Cytology and Histopathology in the diagnosis of lymph node pathologies at health facilities located in Hawassa: A 5-year retrospective study

et al. 2022

View full text Add to dashboard Cite

Objective: The aim of this study was to evaluate the performance of Fine Needle Aspiration Cytology in the diagnosis of lymph node pathologies in comparison with Histopathologic examination. Methods: A retrospective health facility-based cross-sectional study was carried out at health facilities located in Hawassa city among 101 patients who had both Fine Needle Aspiration Cytology and Histopathologic examination on the same site from 13 September 2016 to 30 August 2021. Background data were collected using a structured questionnaire and analyzed by SPSS version 20. Results: A total of 3892 patients had Fine Needle Aspiration Cytology for lymphadenopathies within a specified 5-year span, out of which 101 cases had both Fine Needle Aspiration Cytology and Histopathologic examination. The overall sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of fine needle aspiration cytology for the diagnosis of lymphoma were 88.2%, 92%, 91.8%, 88.5%, and 90.1%, respectively. Conclusions: Fine Needle Aspiration Cytology can be recommended for clinically significant lymphadenopathy as a first-line diagnostic test since it is fast, safe, cost-effective, reasonably sensitive, and specific with significant positive and negative predictive values and diagnostic accuracy.

show abstract

Cytological Diagnosis of Aggressive Small-Cell Lymphomas

Cited by 3 publications

References 91 publications

Utility and Limitations of Fine-Needle Aspiration Cytology in the Diagnosis of Lymphadenopathy

Utility and Limitations of Fine-Needle Aspiration Cytology in the Diagnosis of Lymphadenopathy

Combined fine needle aspiration cytology and core needle biopsy in the same setting: A two‐years’ experience

Comparison of Fine Needle Aspiration Cytology and Histopathology in the diagnosis of lymph node pathologies at health facilities located in Hawassa: A 5-year retrospective study

Contact Info

Product

Resources

About