Comparison of Fine Needle Aspiration Cytology and Histopathology in the diagnosis of lymph node pathologies at health facilities located in Hawassa: A 5-year retrospective study

Taye, Endeshaw; Ali, Musa Mohammed; Toma, Alemeyehu; Alem, Alemwosen Teklehaimanot

doi:10.1177/20503121221138324

Cited by 5 publications

(8 citation statements)

References 17 publications

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“…On the other hand, we found FNAC to be more reliable at diagnosing metastatic malignancies, with an overall accuracy of 90.4%. This is supported by several authors who report an accuracy of FNAC of up to 95%-100% [15][16][19][20][21][22][23]. It has been suggested that since the diagnosis of metastatic carcinomas can be accomplished by relying only on cytomorphological features, unlike lymphoproliferative disorders, FNAC could be much more valuable in the diagnosis of metastatic malignancies than lymphomas.…”

Section: Discussionmentioning

confidence: 82%

Diagnostic Accuracy of Fine-Needle Aspiration Cytology in Cervical Lymphadenopathies at a Tertiary Care Center in the Kingdom of Bahrain

Qader,

Mubarak

et al. 2024

Cureus

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Introduction Fine-needle aspiration cytology (FNAC) has become widely used as a first-line diagnostic tool in the evaluation of cervical lymphadenopathies (LADs). However, there are conflicting reports regarding its accuracy in differentiating between malignant and benign pathologies. In this study, we aim to determine the reliability of FNAC in distinguishing between benign and malignant pathologies causing cervical LAD. Methods This is a cross-sectional study reviewing the electronic medical records of all patients who underwent both FNAC and excisional biopsy of cervical LADs between January 2016 and December 2023 at a tertiary care center in the Kingdom of Bahrain. A comparison was conducted between the cytopathological results obtained by FNAC and the histopathological results obtained by excisional biopsy to determine the diagnostic accuracy of FNAC. Results In the study period, 83 patient records were reviewed and included in the data analysis. Fine-needle aspiration cytology yielded a sensitivity of 89.3%, a specificity of 55.6%, a positive predictive value (PPV) of 72.4%, a negative predictive value (NPV) of 80.0%, and an overall accuracy of 74.7% in diagnosing cervical LADs. Conclusion Despite FNAC being accessible, convenient, and cost-effective, it has certain limitations that can restrict its accuracy in diagnosing lymphomas. We recommend further studies to research these limitations and the possible tools, such as ancillary testing, that may be useful in overcoming them.

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Section: Discussionmentioning

confidence: 82%

Diagnostic Accuracy of Fine-Needle Aspiration Cytology in Cervical Lymphadenopathies at a Tertiary Care Center in the Kingdom of Bahrain

Qader,

Mubarak

et al. 2024

Cureus

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“…The 1-year webinar covered the practical aspects of preparing samples from FNA for manual IHC in resource limited settings. The interactive webinar was attended by 98 participants from eight SSA countries, many of whom remarked on the high importance and relevance of the topic [ 17 – 22 ].…”

Section: Discussionmentioning

confidence: 99%

Building pathology capacity in sub-Saharan Africa to improve breast cancer diagnosis and treatment: training laboratory technicians in high-quality manual immunohistochemistry

Setiawan,

Graef,

Schmolze

et al. 2024

BMC Cancer

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Background To address the need for a skilled workforce in breast cancer (BC) pathology in sub-Saharan Africa (SSA), we implemented an education program to train laboratory technicians in manual immunohistochemistry (IHC). Methods A quality improvement education project was developed. Interactive webinars were held every six months with didactics and presentations from African experts with experience in IHC. We conducted knowledge assessments and surveys on current practice, equipment, and human resources. A digital mentorship platform (DMP) was created for discussions, sharing SOPs, and networking. For one year (2022–2023), we followed developments in pathology capacity, practice changes, and educational needs. A paired t-test was used to calculate the significance of changes in knowledge immediately after the webinar and comfort level with topics 35 days after the webinar. Results Two hundred and sixty six participants from 10 SSA countries attended the first webinar, a series of six lectures on IHC theory, methods, and practice. Ninety-five participants from nine SSA countries provided a baseline assessment of pathology capacity and feedback. Mean knowledge increased by 17.4% immediately after the webinar (from 41.8% pre-webinar to 59.2% post, p = < 0.0001). Self-reported comfort level in topics 35 days after the webinar increased by 11.3%, but this was not statistically significant (mean 3.36 pre- to 3.74 post, p = 0.1). Over six months, recordings were accessed 412 times. After six months, the second webinar had 93 participants from eight SSA countries. Membership in the DMP increased from 64 to 172; recordings were viewed 412 times in six months; and 113 participants from nine SSA countries completed surveys. Among 74 respondents who perform IHC, 43.5% reported moderate or significant positive practice changes such as improved antigen retrieval techniques and optimization of preanalytical variables. Over half (52.7%, n = 39) reported the quality of slides had moderately or significantly improved. After one year, a third webinar had 98 participants from eight SSA countries. Thirty-eight completed surveys, DMP membership increased to 199, and 1 reported launching IHC in a lab in Nigeria. Conclusions Our program 1) reached hundreds of participants and provided a baseline assessment of pathology capacity across nine SSA countries; 2) created a novel mechanism to build pathology capacity and assess progress with this cohort; and 3) improved practices and the preparation of slides for over half performing manual IHC. After one year, interest was sustained. Tracking impact on diagnosis and treatment of BC in the region is needed long-term.

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“…Shariff et al report a sensitivity of 87.5%, specificity of 100%, and efficiency of 98% for FNAC (5). Taye et al reported that FNAC had an overall sensitivity of 88.2% and specificity of 92% for the diagnosis of lymphoma (18). Prasad and Mohan showed sensitivities, specificities, and positive and negative predictive values of 88.2%, 92%, 91.8%, and 88.5%, respectively (19).…”

Section: Discussionmentioning

confidence: 99%

A Prospective Study Comparing Diagnosis of Neck Swellings by Fine Needle Aspiration Cytology with Histopathology

Saleem,

Hashmat,

Rashid

et al. 2023

PJMHS

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Aim: To to correlate the fine needle aspiration cytology findings with histopathology findings of specimens from neck swellings. Study Design; Cross-Sectional Observational Setting: Pathology Department, Chandka Medical College, Larkana Period: June 2021 to June 2023 Methods: This study consisted of neck swelling samples received in the Department of Pathology by FNAC or excision. Both Cytology and Histopathology were evaluated by an experienced pathologist. Diagnoses of cytology were compared with the histopathological examination and the data was recorded into groups that comprised of lymph nodes, thyroid gland, and salivary glands. Lesions that did not fit into these groups were classified into as “others”. Data was entered and analyzed using SPSS Version-22. Results: There were a total of 261 cases of neck swelling samples received in our department. Most of the cases were due to lymph node (n=104) pathologies notably due to reactive hyperplasia and tuberculosis. The thyroid gland (n=95) was the second most common region for FNAC and most samples showed the diagnosis of colloid goiter followed by follicular adenomas. There were n=30 samples of salivary glands whereas n=32 were classified into others. Overall sensitivity and specificity were variable among the regions of FNAC with the highest being (100%) in the salivary glands and lesions classified into others category. Practical Implication: Comparing neck swelling diagnosis via Fine Needle Aspiration Cytology (FNAC) with Histopathology is vital to validate FNAC's accuracy before definitive treatment. It ensures informed decision-making, avoiding unnecessary surgeries and minimizing risks. Conclusion: FNAC of the neck swellings is a highly accurate technique and provides the first line of diagnosis. However, FNAC does have its own limitations and this technique should always be complemented by a confirmatory histopathology. Keywords: Fine needle Aspiration Cytology, Neck Swellings, Lymph node, Salivary Glands, Thyroid Glands

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Comparison of Fine Needle Aspiration Cytology and Histopathology in the diagnosis of lymph node pathologies at health facilities located in Hawassa: A 5-year retrospective study

Cited by 5 publications

References 17 publications

Diagnostic Accuracy of Fine-Needle Aspiration Cytology in Cervical Lymphadenopathies at a Tertiary Care Center in the Kingdom of Bahrain

Diagnostic Accuracy of Fine-Needle Aspiration Cytology in Cervical Lymphadenopathies at a Tertiary Care Center in the Kingdom of Bahrain

Building pathology capacity in sub-Saharan Africa to improve breast cancer diagnosis and treatment: training laboratory technicians in high-quality manual immunohistochemistry

A Prospective Study Comparing Diagnosis of Neck Swellings by Fine Needle Aspiration Cytology with Histopathology

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