Cytological and clinical observations during vincaleukoblastine therapy of disseminated cancer

Vaitkevicius, V. K.; Talley, Robert W.; Tucker, Joanne; Brennan, Michael J.

doi:10.1002/1097-0142(196203/04)15:2<294::aid-cncr2820150213>3.0.co;2-e

Cited by 42 publications

(4 citation statements)

References 22 publications

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“…This is because the mitotic activity of the erythroid lineage in bone marrow is much higher than the mitotic activity of the myeloid lineage . Other studies have also shown the susceptibility of the erythroid lineage to vincristine …”

Section: Discussionmentioning

confidence: 99%

Erythrocyte dysplasia in peripheral blood smears from 5 thrombocytopenic dogs treated with vincristine sulfate

Collicutt

Garner

2013

Veterinary Clinical Pathol

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Secondary dyserythropoiesis has been associated with vincristine administration in dogs. Evaluation of bone marrow aspirates for the presence of morphologic abnormalities in the erythroid lineage aids in the diagnosis. However, morphologic features of circulating erythroid precursors in these cases have not been described previously. The purpose of this report was to describe the cytologic features of dyserythropoiesis in peripheral blood and also bone marrow smears in a case series of dogs with immune-mediated thrombocytopenia (IMT) treated with vincristine sulfate. Nineteen dogs receiving vincristine for treatment of IMT were identified by retrospectively searching a computerized medical record system. There were 5 dogs that had dysplastic erythroid precursors in peripheral blood smears within 7 days of vincristine treatment. Two of those 5 dogs also had evidence for erythrodysplasia in modified Wright's-stained bone marrow smears obtained postvincristine administration. Morphologic changes included bizarre or inappropriate mitotic figures, abnormal nuclear configurations (fragmentation, elongation, indentation, and binucleation), atypical nuclear remnants (Howell-Jolly bodies), or nuclear and cytoplasmic asynchrony within the erythroid precursors. A brief review of the literature with discussion of the etiologies for dyserythropoiesis is provided. The dyserythropoiesis was clinically insignificant in all 5 cases and resolved. However, pathologists and clinicians should be aware of these potential findings to prevent misdiagnosis of other conditions.

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Section: Discussionmentioning

confidence: 99%

Erythrocyte dysplasia in peripheral blood smears from 5 thrombocytopenic dogs treated with vincristine sulfate

Collicutt

Garner

2013

Veterinary Clinical Pathol

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“…Although the M:E ratio initially increases, by 72 to 144 hours it has fallen to abnormally low levels as rapid erythroid regeneration antedates the granulocyte recovery. 21 then rapid fall in M:E ratio has been seen after both 5fluorouracil" and high-dose methotrexate. ' Podophyllin, and its derivative podophyllotoxin, act in a similar fashion to vincristine and vinblastine, producing a temporary mitotic arrest by binding to the mitotic spindle protein t~b u l i n .~~-~' They have long been recognized as antitumor agents with their first and major use in the therapy of c~n d y l o m a t a .~~ VP-16-2 13, a derivative of podophyllotoxin, was first synthesized in 197 I.…”

Section: Discussionmentioning

confidence: 99%

Bone marrow morphologic changes after combination chemotherapy including VP-16

Adelstein

Hines

1985

Cancer

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Bone marrow aspirates and biopsy specimens were examined from seven patients with small cell lung cancer. All patients had received recent combination chemotherapy including VP-16. No correlation between marrow biopsy cellularity and hematologic toxicity could be established. However, an unusual combination of morphologic changes was seen. This included an initial rapid increase in the M:E ratio, interference with cell division, and eventual cell death. There was little evidence of mitotic arrest or megaloblastosis. These changes are consistent with the known mechanism of action of VP-16, the only agent given to all patients. The small sample size and the unknown contributions of the other cytotoxic agents administered allow only limited conclusions.

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“…They have surmised that the alkaloid acts as an antimetabolite, since cytotoxic effects in vitro can be prevented by the addition of glumatic acid. Vaitkevicius et al (1962) have shown that the clinical response and effect on mitosis produced by VLB can be modified by concomitant administration of glutamic acid.…”

Section: Mode Of Actionmentioning

confidence: 99%

“…S. H. MEHTA, MD, MRCPE, Registrar and H. G. MATHER, MA, MD, MRCP, Physician, Southmead Hospital, Bristol Vinblastine sulphate (Vincaleul<.oblastine, VLB) an indole-indoline alkaloid isolated from a tropical variety of the common, decorative, periwinkle plant (Vinca rosea Linn), has some interesting properties (Svoboda et al 1962), and affects various malignant conditions (Vaitkevicius et al 1962). While investigating the hypoglycaemic property of this plant, the Canadian group of Noble et al (1958) observed a peripheral granulocytopenic action and bone marrow depression, which led to testing the effect of VLB on leukaemias and malignant neoplasms.…”

Section: Vinblastine Sulphate Treatment Of Malignant Lymphomasmentioning

confidence: 99%