Cytologic findings in tenosynovial giant cell tumors investigated by fine-needle aspiration cytology

Layfield, Lester J.; Moffatt, Elizabeth J.; Dodd, Leslie G.; Scully, Sean P.; Harrelson, John M.

doi:10.1002/(sici)1097-0339(199704)16:4<317::aid-dc3>3.0.co;2-a

Cited by 26 publications

(11 citation statements)

References 3 publications

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“…Previous cytology reports of GCTTS have not made a distinction between these cell types, although the polygonal cell type is clearly recognizable in earlier reports. 8 Giant cells were found in FNA smears in all our cases in good numbers, and almost all cases showed giant cells with 20 or more nuclei. These resemble osteoclasts and the combination of the typical stromal and giant cell components in aspirates of soft tissue tumors from compatible sites is virtually diagnostic of GCTTS.…”

Section: Discussionmentioning

confidence: 51%

Fine‐needle aspiration cytology of giant cell tumor of tendon sheath

Iyer

Kapila

Verma

2003

Diagnostic Cytopathology

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Giant cell tumor of tendon sheath (GCTTS) is a unique soft tissue lesion of the hands and feet. As the cytomorphological features of this lesion are rarely documented, the spectrum of cytomorphological features in 20 cases of GCTTS seen in fine-needle aspiration (FNA) smears are presented. Patients were in the 12-64-yr age group with an equal sex ratio. Fingers or thumb were the commonest site (16 cases), followed by foot (3 cases) and palm (1 case). FNA smears were cellular and composed of varying proportions of stromal and giant cells. Stromal cells showed a dispersed arrangement and were polygonal to spindle shaped. Nuclear grooves and convolutions were found in some of the stromal cells in all cases. Intranuclear cytoplasmic inclusions were occasionally seen. Polygonal cells with round nuclei and nucleoli having abundant cytoplasm, along with binucleate forms, were also found in all cases. Histological sections were available in 10 cases and corroborated the cytological features. Hemosiderin-laden macrophages (11 of 20 cases) and abundant foamy vacuolation of stromal cells (3 of 20 cases) were also observed in FNA smears. In tissue sections, both features were seen in all cases, but with a patchy distribution. The cytological features of GCTTS are uniform, and FNA cytodiagnosis is possible.

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Section: Discussionmentioning

confidence: 51%

Fine‐needle aspiration cytology of giant cell tumor of tendon sheath

Iyer

Kapila

Verma

2003

Diagnostic Cytopathology

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“…The above mentioned cytologic features were similar to those of the previous reports. [3][4][5][6][7] In addition, our case's FNA smears disclosed several clumps of acellular, dense collagenous stromal tissue as one of the important histologic features, but this has seldom been reported in the previous cytology reports. 6 The present cytologic examination did not show xanthoma cells.…”

Section: Histologic Findingsmentioning

confidence: 49%

Touch Imprint and Fine Needle Aspiration Cytology of Giant Cell Tumor of Tendon Sheath: A Case Report

Lee

2008

Korean J Cytopathol

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INTRODUCTIONGiant cell tumors of the tendon sheath (GCTTS) are the second most common lesion of the hand, with simple ganglion cysts being the most common. This tumor was first described by Chassaignac, who referred to it as a "cancer of the tendon sheath". 1 Giant cell tumor of the tendon sheath (GCTTS) is a slowly growing, benign soft tissue tumor. The tumors occur predominantly on the hands and feet. Although the clinical and histopathologic features are well-defined, only a few reports have described the cytologic appearance of this entity. A 26-year-old woman presented with a gradually developing circumscribed soft tissue mass near the proximal phalanx of her left little finger for one year. Imprint and fine needle aspiration (FNA) smears were obtained from the excisional biopsy specimen. The imprint smears were composed of predominantly singly dispersed bland mononuclear cells and several giant cells. The mononuclear cells were polygonal to round, and they showed a histiocyte-like appearance. Osteoclast-type multinucleated giant cells of various sizes were randomly scattered throughout the smears, and these cells contained 3 to 50 nuclei. Nuclear atypia and pleomorphism were absent in both the single and giant cells. Loose aggregates of hemosiderin-laden macrophages and binuclear stromal cells were also seen. The cytologic features of the FNA smears were similar with those of the imprint. Additionally, the FNA smears contained several clumps of densely collagenous stromal tissue that were seldom noted in previously reported cytologic material. The cytologic features were well-correlated with the concurrent histologic findings and the diagnosis of GCTTS was made. When the clinical and radiologic datas are integrated, the diagnosis of GCTTS can be strongly suggested, based on the pre-operative cytologic specimen. CASE Clinical PresentationA 26-year-old woman presented with a soft tissue mass around the little finger of the left hand and intermittent pain for one year. The mass had recently been increasing in size. There was no history of trauma or significant past medical history. On physical examination, there was no discoloration of the overlying skin.The soft tissue mass was located near the proximal phalanx of the little finger, and the mass measured 2 × 1 cm. It was firm, slightly mobile and nontender on palpation. There was no effusion in the joint space. The MRI scan showed a well-circumscribed, extraarticular soft tissue mass with no bony destruction and it suggested giant cell tumor of the tendon sheath (Fig. 1).Excisional biopsy was performed. The specimen was a well-demarcated tan nodule with a lobulated contour, and it measured 2.7×2×0.5 cm. Scanty thick yellowish material was noted on the external surface. The cut surface was gray white and solid with focal yellow flecks at the periphery. Fine needle aspiration was performed on the surgical specimen with using a 10 ml disposable syringe attached to a 22 gauge needle. A number of smears were made. Additionally, touch imprint smears were prepare...

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“…[4789] The histologic criteria for malignant TGCT include five out of eight characteristics including diffuse pleomorphism, prominent nucleoli, high nuclear cytoplasmic ratio, mitosis >10/10 HPFs, necrosis, discohesion of tumor cells, paucity of giant cells, and a diffuse growth pattern. [9] FNA cytology of our case showed diffuse pleomorphism, prominent nucleoli, high nucleocytoplasmic ratio, frequent mitoses, and discohesion of tumor cells. The differential diagnoses of malignant D-TGCT are undifferentiated pleomorphic sarcoma, fibrosarcoma, and myxosarcoma.…”

Section: Discussionmentioning

confidence: 99%

Fine needle aspiration cytology diagnosis of metastatic malignant diffuse type tenosynovial giant cell tumor

Ramteke

Iyer

Madan

et al. 2017

J Cytol

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Tenosynovial giant cell tumors (TGCTs) arise from the synovium of joint, bursa, and tendon sheath, and are classified into localized and diffuse types. Diffused type often affects the large joint, and has more recurrence, metastasis, and malignant transformation potential compared to the localized type. Malignant diffused TGCT (D-TGCT) usually occurs as a large tumor (>5 cm), in older patients, and its histopathologic features include necrosis, cellular anaplasia, prominent nucleoli, high nuclear cytoplasmic ratio, brisk mitosis, discohesion of tumor cells, paucity of giant cells, and a diffuse growth pattern. At least five of these criteria are required for the histopathologic diagnosis of malignant TGCT because the benign TGCT also shares many of these morphological features. We describe the cytomorphologic features of a malignant D-TGCT from an unusual case of pulmonary metastasis in an adult patient. Fine needle aspiration cytologic features of malignant D-TGCT have not been described earlier in the English literature.

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Cytologic findings in tenosynovial giant cell tumors investigated by fine-needle aspiration cytology

Cited by 26 publications

References 3 publications

Fine‐needle aspiration cytology of giant cell tumor of tendon sheath

Fine‐needle aspiration cytology of giant cell tumor of tendon sheath

Touch Imprint and Fine Needle Aspiration Cytology of Giant Cell Tumor of Tendon Sheath: A Case Report

Fine needle aspiration cytology diagnosis of metastatic malignant diffuse type tenosynovial giant cell tumor

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