Fine‐needle aspiration cytology of giant cell tumor of tendon sheath

Iyer, Venkateswaran K.; Kapila, Kusum; Verma, Kusum

doi:10.1002/dc.10319

Cited by 39 publications

(63 citation statements)

References 12 publications

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“…The above mentioned cytologic features were similar to those of the previous reports. [3][4][5][6][7] In addition, our case's FNA smears disclosed several clumps of acellular, dense collagenous stromal tissue as one of the important histologic features, but this has seldom been reported in the previous cytology reports. 6 The present cytologic examination did not show xanthoma cells.…”

Section: Histologic Findingsmentioning

confidence: 48%

“…Previously, Iyer VK et al 6 briefly mentioned the presence of focal nuclear debris in the FNA smears of GCTTS, and Monaghan H et al 9 documented apoptotic bodies in the areas with numerous giant cells on the histologic sections. However, apoptotic bodies have not been consistently described on the histologic sections of the previous reports 2, 8 and true cell necrosis was absent in the previous cytology literature.…”

Section: Histologic Findingsmentioning

confidence: 99%

“…However, apoptotic bodies have not been consistently described on the histologic sections of the previous reports 2, 8 and true cell necrosis was absent in the previous cytology literature. 3,[5][6][7] Cellular debris, apoptotic bodies or necrosis were absent in the imprint smears and the histologic sections In summary, the present article evaluated the cytomorphologic features of a case of GCTTS with using both imprint and FNA smears, and we compared these with the corresponding histologic features. When interpreted along with the clinical features, the diagnosis of GCTTS can be suggested based on the cytologic specimen.…”

Section: Histologic Findingsmentioning

confidence: 99%

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Touch Imprint and Fine Needle Aspiration Cytology of Giant Cell Tumor of Tendon Sheath: A Case Report

Lee

2008

Korean J Cytopathol

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INTRODUCTIONGiant cell tumors of the tendon sheath (GCTTS) are the second most common lesion of the hand, with simple ganglion cysts being the most common. This tumor was first described by Chassaignac, who referred to it as a "cancer of the tendon sheath". 1 Giant cell tumor of the tendon sheath (GCTTS) is a slowly growing, benign soft tissue tumor. The tumors occur predominantly on the hands and feet. Although the clinical and histopathologic features are well-defined, only a few reports have described the cytologic appearance of this entity. A 26-year-old woman presented with a gradually developing circumscribed soft tissue mass near the proximal phalanx of her left little finger for one year. Imprint and fine needle aspiration (FNA) smears were obtained from the excisional biopsy specimen. The imprint smears were composed of predominantly singly dispersed bland mononuclear cells and several giant cells. The mononuclear cells were polygonal to round, and they showed a histiocyte-like appearance. Osteoclast-type multinucleated giant cells of various sizes were randomly scattered throughout the smears, and these cells contained 3 to 50 nuclei. Nuclear atypia and pleomorphism were absent in both the single and giant cells. Loose aggregates of hemosiderin-laden macrophages and binuclear stromal cells were also seen. The cytologic features of the FNA smears were similar with those of the imprint. Additionally, the FNA smears contained several clumps of densely collagenous stromal tissue that were seldom noted in previously reported cytologic material. The cytologic features were well-correlated with the concurrent histologic findings and the diagnosis of GCTTS was made. When the clinical and radiologic datas are integrated, the diagnosis of GCTTS can be strongly suggested, based on the pre-operative cytologic specimen. CASE Clinical PresentationA 26-year-old woman presented with a soft tissue mass around the little finger of the left hand and intermittent pain for one year. The mass had recently been increasing in size. There was no history of trauma or significant past medical history. On physical examination, there was no discoloration of the overlying skin.The soft tissue mass was located near the proximal phalanx of the little finger, and the mass measured 2 × 1 cm. It was firm, slightly mobile and nontender on palpation. There was no effusion in the joint space. The MRI scan showed a well-circumscribed, extraarticular soft tissue mass with no bony destruction and it suggested giant cell tumor of the tendon sheath (Fig. 1).Excisional biopsy was performed. The specimen was a well-demarcated tan nodule with a lobulated contour, and it measured 2.7×2×0.5 cm. Scanty thick yellowish material was noted on the external surface. The cut surface was gray white and solid with focal yellow flecks at the periphery. Fine needle aspiration was performed on the surgical specimen with using a 10 ml disposable syringe attached to a 22 gauge needle. A number of smears were made. Additionally, touch imprint smears were prepare...

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Section: Histologic Findingsmentioning

confidence: 48%

Section: Histologic Findingsmentioning

confidence: 99%

Section: Histologic Findingsmentioning

confidence: 99%

See 1 more Smart Citation

Touch Imprint and Fine Needle Aspiration Cytology of Giant Cell Tumor of Tendon Sheath: A Case Report

Lee

2008

Korean J Cytopathol

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“…In GCTTs, FNAC shows a polymorphic population composed of mononuclear histiocyte-like cells, hemosiderin-laden macrophages, foamy macrophages and a few multinucleated giant cells [7,8] . FNAC can be used as a diagnostic tool for an early and accurate detection of GCTTs as the cytological features, and clinico-radiological correlation are sufficiently diagnostic [7,8] . Thus, FNAC helps in preoperative planning to prevent recurrence [8] .…”

Section: Dear Editormentioning

confidence: 99%

“…FNAC can be used as a diagnostic tool for an early and accurate detection of GCTTs as the cytological features, and clinico-radiological correlation are sufficiently diagnostic [7,8] . Thus, FNAC helps in preoperative planning to prevent recurrence [8] . differential diagnoses of GCTTs include ganglion, lipoma, foreign body granuloma, tophaceous gout, haemangioma, glomus tumour, enchondroma, osteoid osteoma, osteoblastoma, schwannoma, and circum scribed fibromatosis [6] .…”

Section: Dear Editormentioning

confidence: 99%

Giant cell tumor of tendon sheath—Use of fine-needle aspiration cytology for diagnosis

Meena

Arora²

2017

J Surg Dermatol

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Citation: Meena N and Arora P. Giant cell tumor of tendon sheath-Use of fine-needle aspiration cytology for diagnosis. J surg dermatol 2017; 2(4) : 195-196 Dear Editor, Giant cell tumour of the tendon sheath (GCTTs) is a slowgrowing, usually painless benign lesion of soft tissues [1] . We report the case of a 38-year-old male with a painless, slowly enlarging swelling on right thumb in order to highlight the role of fine-needle aspiration cytology (FNAC) in diagnosing GCTTs.A 38-year-old male presented with a painless, slowly enlarging swelling on his right thumb from last six months. There was no history of injury to the affected area. On examination, there was a 3-cm × 1-cm mass with normal overlying skin on the ulnar aspect of the right thumb at interphalangeal joint (Figure 1). It was non-tender, firm, well-circumscribed and fixed to the underlying structures with non-adherent overlying skin. X-ray of the right hand showed soft tissue swelling in the right thumb. Ultrasonography revealed a lobulated, well-defined, hypoechoic lesion in close approximation of the underlying tendon. However, the integrity of the underlying tendon was maintained. FNAC was suggestive of giant cell tumor of tendon sheath.

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Giant cell tumor of soft tissue: FNA cytopathology of 4 cases, review of the literature, and comparison with giant cell tumor of bone

Wakely

2021

Cancer Cytopathology

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Background The cytopathology of a giant cell tumor of soft tissue (GCT‐ST), a fibrohistiocytic neoplasm distinct from other giant cell–rich soft tissue tumors, is rarely reported. The authors report their experience with a series of 4 GCT‐ST fine‐needle aspiration (FNA) biopsy cases and compare them with a set from giant cell tumors of bone (GCTBs). Methods The authors' cytopathology files were searched for GCT‐ST examples with histopathologic confirmation. FNA biopsy smears were performed and examined with standard techniques. Results Four cases of GCT‐ST presenting as a primary soft tissue mass from 4 patients (3 males and 1 female; age range, 28‐75 years, mean age, 53 years) were retrieved. FNA sites included the anterior tibia, buttock, shoulder, and upper back. Three cases were interpreted as suspicious for sarcoma radiographically. The specific diagnoses were atypical giant cell tumor of tendon sheath, suspicious for GCT‐ST, atypical myxoid lesion with giant cells, and benign with osteoclast‐like giant cells (OLGCs). No case was interpreted as malignant. Aspirates consisted of mononuclear polygonal cells, spindled fibroblast cell clusters, and large OLGCs to the near exclusion of other cell types. OLGCs possessed 10 or more nuclei per cell. A comparison with GCTB aspirates and single case reports from the literature showed comparable cytomorphology. Conclusions GCT‐ST FNA smears mimic those of GCTBs containing a limited population of uniform spindle cell clusters, single dispersed polygonal cells, and cytologically banal OLGCs. GCT‐ST should be considered in the differential diagnosis of aspirates containing numerous osteoclast‐like giant cells.

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Fine‐needle aspiration cytology of giant cell tumor of tendon sheath

Cited by 39 publications

References 12 publications

Touch Imprint and Fine Needle Aspiration Cytology of Giant Cell Tumor of Tendon Sheath: A Case Report

Touch Imprint and Fine Needle Aspiration Cytology of Giant Cell Tumor of Tendon Sheath: A Case Report

Giant cell tumor of tendon sheath—Use of fine-needle aspiration cytology for diagnosis

Giant cell tumor of soft tissue: FNA cytopathology of 4 cases, review of the literature, and comparison with giant cell tumor of bone

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