Cytologic Features of Well-Differentiated Villoglandular Adenocarcinoma of the Cervix

Papanicolaou smear sensitivity for the detection of adenocarcinoma of the cervix

“…30 Not surprisingly, these entities may be mistaken cytologically for benign conditions, and the reverse also may be true. In minimal deviation adenocarcinoma, subtle diagnostic clues may include the presence of large sheets of enlarged glandular cells with uniform nuclei; however, these features may be recognizable only retrospectively.…”

Well-Differentiated Villoglandular Adenocarcinoma of the Uterine Cervix: Assessment of Cytological Features by Histological Subtypes

“…The common cytological features of VGA described in previous reports are the presence of long slender papillae, cohesive branching of epithelial sheets with smooth borders, and the lack of a feathery edge [7,8,9,10,11]. The nuclei were uniform, small, and round to oval-shaped with evenly distributed granular chromatin.…”

“…In smears of reactive endocervical cells desquamated glandular cells in sheets are observed. The nuclei are slightly enlarged and pleomorphic with finely granular chromatin and prominent nucleoli [7]. In distinguishing the tumor cells of VGA from abnormally shaped benign endocervical lesions, crowding or overlapping of the nuclei is one of the clues indicating VGA.…”

“…Although several studies have reported the cytological features of VGA in cervical smears [7,8,9,10,11], there is disagreement about the characteristic features. We hypothesized that the inconsistent features that were described were due to the various types of epithelial cells that compromise this entity.…”

Cytologic Detection of Cervical and Endometrial Carcinoma with Other Genital Tract Involvement

“…1,11,12 Cervical cancer can extend into the uterine cavity and endometrial cancer into the cervical channel. 2,4 Moreover, both can occur concurrently.…”