Cytologic Assessment of Endobronchial Ultrasound-Guided Transbronchial Needle Aspirates in Sarcoidosis

Yield of EBUS-TBNA for the diagnosis of sarcoidosis: impact of operator and cytopathologist experience

“…In the prospective study of Garwood et al , 8 the yield per needle pass exceeded 80% at five passes, with no further increase beyond seven passes. Using the combined data from their RCT of conventional versus EBUS-guided TBNA, Chee et al 6 examined the relative importance of cytological preparations and factors influencing the diagnostic yield in patients with suspected sarcoidosis. Liquid-based cytology and cell blocks were equally important in identifying granulomatous inflammation.…”

“… 5 The clinical factors associated with successful demonstration of non-necrotising granulomatous inflammation in EBUS-TBNA samples have not been clearly established. 6 …”

The use of convex probe endobronchial ultrasound-guided transbronchial needle aspiration in a pediatric population: A multicenter study

“…In one of the largest EBUS‐TBNA studies reported to date, sample adequacy was 90% and diagnostic yield ranged from 37% to 54% depending on hospital volume . While not as well studied in pediatrics, EBUS‐TBNA has become well accepted for the evaluation of lymphadenopathy unrelated to primary lung cancer, such as lymphoma and sarcoidosis …”

“…In overall terms of both adequacy and diagnostic performance, our results are very similar to other reported studies on EBUS-TBNA in the 1 While not as well studied in pediatrics, EBUS-TBNA has become well accepted for the evaluation of lymphadenopathy unrelated to primary lung cancer, such as lymphoma 26,28,29 and sarcoidosis. 1,19,[30][31][32] We have identified several limitations with our study. First, this study is retrospective in nature and therefore all the shortcomings of a retrospective study are inherent within our manuscript.…”

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“…Reliability of negative ("benign") results and findings positive for malignancy/ neoplasia A few studies have analyzed the reproducibility of cytopathological diagnoses of specimens obtained by EUS-guided sampling. A good-to-excellent diagnostic agreement between experienced 15 Terms are explained in the addendum on terminology 17 Terms are explained in the addendum on terminology 16 Terms are explained in the addendum on terminology cytopathologists was documented for the assessment of aspirations from mediastinal lymph nodes and masses [161,405,696], in the Ki-67 labelling index for grading of neuroendocrine pancreatic tumors [697], and in the assessment of core samples obtained with a ProCore needle [97,531]. Fair to moderate interobserver agreement was described for the grading of pancreatic cancer [698], grading of atypia in PCLs [243 -245], and classification of the subtype in NSCLC [699].…”