Nat Cell Biol volume 5, issue 3, P224-230 2003 DOI: 10.1038/ncb942 Retracted 2014-10-31Has correction 2014-10-31
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Miyuki Suzawa, Ichiro Takada, Junn Yanagisawa, Fumiaki Ohtake, Satoko Ogawa, Toshimasa Yamauchi, Takashi Kadowaki, Yasuhiro Takeuchi, Hiroshi Shibuya, Yukiko Gotoh, Kunihiro Matsumoto, Shigeaki Kato
Abstract:

Pluripotent mesenchymal stem cells in bone marrow differentiate into adipocytes, osteoblasts and other cells. Balanced cytodifferentiation of stem cells is essential for the formation and maintenance of bone marrow; however, the mechanisms that control this balance remain largely unknown. Whereas cytokines such as interleukin-1 (IL-1) and tumour-necrosis factor-alpha (TNF-alpha) inhibit adipogenesis, the ligand-induced transcription factor peroxisome proliferator-activated receptor-gamma (PPAR-gamma), is a…

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