Stress-induced cytokine responses and central adiposity in young women

Brydon, Lena; Wright, Caroline; O’Donnell, Katie; Zachary, I; Wardle, Jane; Steptoe, Andrew

doi:10.1038/sj.ijo.0803767

Cited by 64 publications

(58 citation statements)

References 50 publications

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“…Previous studies have reported an association between early-life stress and obesity, and also a relationship between BMI and stress-induced cytokine response (Brydon et al 2008 ;Boynton-Jarrett et al 2010). Obesity itself is accompanied by low-grade inflammation, and adipocytes are a source of IL-6, CRP and serum amyloid A (SAA) (Kvasnicka et al 2003).…”

Section: Discussionmentioning

confidence: 99%

Schizophrenia patients with a history of childhood trauma have a pro-inflammatory phenotype

et al. 2012

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Section: Discussionmentioning

confidence: 99%

Schizophrenia patients with a history of childhood trauma have a pro-inflammatory phenotype

et al. 2012

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“…For example, young women with greater abdominal obesity had larger stress-induced inflammatory responses compared to those with less abdominal obesity [80]. Furthermore, obesity’s impact on reactivity appears to persist for subsequent stressors.…”

Section: Biopsychosocial Risk Factors For Elevated Inflammationmentioning

confidence: 99%

Sex Differences in Depression: Does Inflammation Play a Role?

Derry

Padin

Kuo

et al. 2015

Curr Psychiatry Rep

134

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Women become depressed more frequently than men, a consistent pattern across cultures. Inflammation plays a key role in initiating depression among a subset of individuals, and depression also has inflammatory consequences. Notably, women experience higher levels of inflammation and greater autoimmune disease risk compared to men. In the current review, we explore the bidirectional relationship between inflammation and depression and describe how this link may be particularly relevant for women. Compared to men, women may be more vulnerable to inflammation-induced mood and behavior changes. For example, transient elevations in inflammation prompt greater feelings of loneliness and social disconnection for women than for men, which can contribute to the onset of depression. Women also appear to be disproportionately affected by several factors that elevate inflammation, including prior depression, somatic symptomatology, interpersonal stressors, childhood adversity, obesity, and physical inactivity. Relationship distress and obesity, both of which elevate depression risk, are also more strongly tied to inflammation for women than for men. Taken together, these findings suggest that women’s susceptibility to inflammation and its mood effects may contribute to sex differences in depression. Depression continues to be a leading cause of disability worldwide, with women experiencing greater risk than men. Due to the depression-inflammation connection, these patterns may promote additional health risks for women. Considering the impact of inflammation on women’s mental health may foster a better understanding of sex differences in depression, as well as the selection of effective depression treatments.

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“…Stress also increase cytokine response (86) especially in abdominal obese subjects (87). Insulin resistance is characterized by low-grade inflammation and adipokines such M a n u s c r i p t 15 as TNFalpha decrease both insulin signalling, glucose uptake (88) and capillary recruitment (89).…”

Section: Neuroendocrine Effects On Endothelial Function and Muscle Glmentioning

confidence: 99%

Neuroendocrine mechanisms in insulin resistance

Sjöstrand

Eriksson

2009

Molecular and Cellular Endocrinology

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Dysregulated hormonal, metabolic and neural signalling within and between organs can contribute to development of metabolic diseases including type 2 diabetes. Insulinantagonistic effects of hormones, cytokines and excess metabolic substrates such as glucose and fatty acids may be exerted via common mechanisms involving for example reactive oxygen species (ROS) accumulation and associated inflammatory responses.Visceral adiposity is a central component of the metabolic syndrome and it is also strongly associated with insulin resistance. Both visceral obesity and insulin resistance are important risk factors for the development of type 2 diabetes. In the development of insulin resistance, it is likely that intra-abdominal adipose tissue plays a critical role in a complex endocrine and neural network involving several tissues. This review paper focuses on neuroendocrine 'stress' factors that target insulin-responsive tissues, in particular adipose tissue. We propose that there are common pathways by which dysregulation in different endocrine systems may contribute to the development of type 2 diabetes.

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Stress-induced cytokine responses and central adiposity in young women

Cited by 64 publications

References 50 publications

Schizophrenia patients with a history of childhood trauma have a pro-inflammatory phenotype

Schizophrenia patients with a history of childhood trauma have a pro-inflammatory phenotype

Sex Differences in Depression: Does Inflammation Play a Role?

Neuroendocrine mechanisms in insulin resistance

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