Cytokines in Semen of Normal Men and of Patients With Andrological Diseases

Comhaire, Frank; Bosmans, Eugène; Ombelet, Willem; Punjabi, Usha; Schoonjans, Frank

doi:10.1111/j.1600-0897.1994.tb00853.x

Cited by 68 publications

(45 citation statements)

References 19 publications

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“…LCS was associated with decreased sperm count, % normal forms and fructose concentration, a measure of seminal vesicle function. Thus, the present study confirms and extends earlier reports that STIs and LCS are associated with poor semen quality (7,13,45,48,49,51,64,65,70,(77)(78)(79)(80)(81)(82).…”

Section: Discussionsupporting

confidence: 81%

“…Similarly, concentrations of all three inflammation markers (PMNs, PMN-elastase and IL-1β) were significantly correlated with one another, which was expected, as both PMNs and macrophages are important participants in inflammatory responses, and because numbers of PMNs and macrophages in semen are highly correlated (9,45,48,49,86). STI DNA was not associated with elevations in any of these inflammation markers.…”

Section: Discussionmentioning

confidence: 64%

“…Interleukin-1β (IL-1β)-IL-1β, a proinflammatory cytokine primarily secreted by macrophages and epithelial cells, has been associated with LCS, accessory gland inflammation, CT infection, and decreased sperm parameters (45)(46)(47)(48)(49). We measured concentrations of IL-1β in seminal plasma using a commercially available ELISA kit (Genzyme, Cambridge, MA, USA) following the manufacturer's protocol.…”

Section: Determination Of Il-1β and Biochemical Markersmentioning

confidence: 99%

See 2 more Smart Citations

Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermia

Bezold

Politch

Kiviat

et al. 2007

Fertility and Sterility

214

167

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Objective-To determine the prevalence of pathogens that cause sexually transmitted infections (STIs) in semen from asymptomatic male infertility patients with and without leukocytospermia (LCS), and associations between STIs, inflammatory markers and other semen variables.Design-Retrospective, controlled study. Results-STI DNA was detected in 45/241 (18.7%) of the samples (CMV 8.7%, HPV 4.5%, HHV-6 3.7%, HSV 3.7%, CT 2.5%, EBV 0.4%, and HBV 0%), with no difference in prevalence between LCS and non-LCS groups. STI DNA in semen was associated with a decrease in sperm concentration, motile sperm concentration, total sperm count and neutral α-glucosidase concentration, whereas LCS was associated with a decrease in total sperm count, % normal forms and fructose concentration. Setting-CenterReprint requests: Deborah J. Anderson, Ph.D., Department of Obstetrics and Gynecology, Boston University School of Medicine, 670 Albany Street, Suite 516, Boston, MA 02118, (FAX: 617-414-8481; e-mail: E-mail: deborah.anderson@bmc.org). Capsule: Sexually transmissible pathogens were detected in 19% of semen samples from infertility patients seeking routine semen analyses; their presence was not associated with leukocytospermia, but was associated with reduced semen quality.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Conclusion(s)-STI pathogen DNA was detected in semen from a high percentage of asymptomatic male infertility patients and was associated with poor semen quality. Efforts to diagnose and treat subclinical genital tract infections should be intensified. NIH Public Access

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 64%

Section: Determination Of Il-1β and Biochemical Markersmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermia

Bezold

Politch

Kiviat

et al. 2007

Fertility and Sterility

214

167

View full text Add to dashboard Cite

show abstract

“…Certain proinflammatory cytokines, such as interleukin (IL)-6 and IL-8, are involved in inflammatory processes. Previous studies have investigated levels of seminal IL-6, IL-8, or both in infertile patients, and controversy exists as to whether elevated cytokine levels are related to semen quality (Comhaire et al, 1994;Dousset et al, 1997;EggertKruse et al, 2001;Kopa et al, 2005). To our knowledge, there has been no study in which levels of IL-6 and IL-8 have been measured in semen from males infected with C trachomatis and comparisons made with a group shown not to be infected with chlamydia.…”

mentioning

confidence: 99%

Raised Inflammatory Markers in Semen From Men With Asymptomatic Chlamydial Infection

Kokab

Akhondi

Sadeghi

et al. 2010

Journal of Andrology

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The aim of this study was to determine whether interleukin (IL)-6 and IL-8 concentrations, as well as numbers of seminal leukocytes in a population of infertile men, some of whom were Chlamydia trachomatis positive, were related to chlamydial infection. Our patient group included 255 men attending for diagnostic semen analysis as part of infertility investigations. Significantly raised levels of IL-8, but not IL-6, were found in C trachomatis-infected patients but not in uninfected patients. Raised IL-8 levels in semen were also associated with an increase in semen volume. There was a relationship between C trachomatis infection and lower progressive motile sperm, as well as an increase in seminal leukocytes. The overall prevalence rate for C trachomatis was 6.2%, and more infections were detected in semen than in first void urine. This study supports the suggestion that IL-8 might be used as a marker for male genital tract infection, especially when due to C trachomatis. In this study, there was a relationship between the presence of C trachomatis in semen and alterations of some semen parameters. Further investigations should be performed to understand the disparities of first void urine and semen testing for detection of C trachomatis in males.

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“…Several authors did not ®nd any correlation between seminal cytokine concentrations and spermiogram parameters [10], reporting only a slight correlation between the expression of IL-6 and low sperm concentration [3,5]. Furthermore, Huleihel et al [16] reported that seminal concentration of IL-1, TNF-a, and IL-6 were not di erent in fertile and infertile men.…”

Section: Il-2 Receptors On Human Spermmentioning

confidence: 99%

Expression of IL-2α and IL-2β Receptors on the Membrane Surface of Human Sperm

Fierro

Schwed

Foliguet

et al. 2002

Archives of Andrology

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Cytokines in Semen of Normal Men and of Patients With Andrological Diseases

Abstract: Measurement of in particular IL-6 in semen may contribute to the diagnosis of inflammatory disease of the accessory sex glands (positive predictive value = 98%, sensitivity = 72%, specificity = 94%), but it is not relevant for the diagnosis of immunological disease.

Cited by 68 publications

References 19 publications

Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermia

Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermia

Raised Inflammatory Markers in Semen From Men With Asymptomatic Chlamydial Infection

Expression of IL-2α and IL-2β Receptors on the Membrane Surface of Human Sperm

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