Cytokines in Nasal Polyposis, Acute and Chronic Sinusitis

Rudack, Claudia; Stoll, Wolfgang; Bachert, Claus

doi:10.2500/105065898780708008

Cited by 102 publications

(74 citation statements)

References 28 publications

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“…Essas células são geralmente associadas à inflamação aguda 1,4 . Muitos autores falam em diversos tipos de alterações histológicas nas RSC e a predominância de neutrófilos pode se encaixar em um desses tipos.…”

Section: Discussionunclassified

Histopatologia da lâmina própria do seio maxilar na rinossinusite crônica

Sarreta

Dorgam

Souza

et al. 2004

Rev. Bras. Otorrinolaringol.

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A rinossinusite crônica é definida de modo simplificado como uma inflamação crônica da mucosa nasossinusal. Objetivo: Na tentativa de entender o porquê das falhas terapêuti-cas. Forma de estudo: Caso-controle. Material e método: Decidimos estudar as alterações inflamatórias ultraestruturais encontradas na lâmina própria do seio maxilar de 13 pacientes portadores de rinossinusite crônica (RSC) e polipose nasossinusal (PNS), submetidos a tratamento cirúrgico. Biópsias da parede súpero-lateral do seio maxilar desses pacientes foram colhidas durante o ato operatório e, após preparação, observadas através de microscopia eletrônica de transmissão. Resultado: Na análise dos dados obtidos, observou-se cinco padrões de resposta inflamatória nas lâminas próprias estudadas inflamatório crônico. Processo inflamatório agudo -1 caso; processo inflamatório não agudo e não crônico -5 casos; processo inflamatório crônico -2 casos; processo inflamató-rio desorganizado -4 casos; processo inflamatório indeterminado -1 caso. Concluindo, a análise dos resultados mostrou que a lâmina própria do seio maxilar desses pacientes esteve infiltrada por células inflamatórias, sem predomí-nio específico de qualquer elemento celular. Elementos glandulares não foram observados nos casos estudados e a fibrose foi notada em quase metade deles, com intensidade variada e localização preferencial logo abaixo do epitélio. Conclusão: Na situação vista, o processo inflamatório não seguiu as etapas normais de evolução, mostrou marcante desorganização do processo inflamatório, dificuldade em caminhar até a resolução do quadro, acompanhando a mesma dificuldade de resolução clínica nos pacientes.

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Section: Discussionunclassified

Histopatologia da lâmina própria do seio maxilar na rinossinusite crônica

Sarreta

Dorgam

Souza

et al. 2004

Rev. Bras. Otorrinolaringol.

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“…Patients with AFS often have elevated levels of the CXC chemokines IL-8, which is a functional homologue of KC, and MIP-2 (23). Increased levels of CXC chemokines following Aspergillus exposure have also been reported in murine models of invasive aspergillosis (3,(12)(13)(14).…”

Section: Discussionmentioning

confidence: 99%

Role of Neutrophils in Preventing and Resolving Acute Fungal Sinusitis

et al. 2007

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Acute fungal sinusitis (AFS) is a devastating disease of the paranasal sinuses afflicting immunocompromised individuals. Knowledge about this disease is limited to clinical observations because there are no animal models in which to study the pathogenesis of the infection. Our goal was to develop a murine model of AFS and examine the role of neutrophils in host defense within the nasal cavity. Female C57BL/6 mice were depleted of neutrophils using anti-Gr-1 monoclonal antibody from day ؊1 to day 5 postinfection to initiate a transient neutropenia within the mice. At day 0, Aspergillus fumigatus conidia were administered intranasally. The untreated Aspergillus-exposed group had significant neutrophil recruitment by day 3, but by day 7 the leukocyte numbers had returned to unexposed levels. There was not a significant influx of mononuclear cells at either time point. In contrast, beginning at day 3 postinfection and continuing through day 7, anti-Gr-1-treated mice had increased cellular recruitment consisting of banded neutrophils at day 3 and mature neutrophils at day 7. Hyphal masses developed only in the anti-Gr-1-treated mice (25 to 36%) but only during the period of treatment. When the treatment was discontinued, hyphal masses could no longer be detected in the nasal cavities of these mice. In contrast, cyclophosphamide treatment did not induce neutropenia, and the nasal cavity remained free of hyphal masses. These studies demonstrate the feasibility of using this model to study AFS and implicate neutrophils in protection of the sinuses against acute Aspergillus infection and in clearance of established hyphal masses.Acute fungal sinusitis (AFS), also known as fulminant sinusitis, is a rapid, invasive disease of the paranasal cavities. It develops primarily in immunocompromised individuals, such as bone marrow transplant and AIDS patients (5, 21). The infection is characterized by rapid hyphal transformation within the paranasal sinus cavities. This is followed by fungal invasion of the surrounding mucosa, musculature, vasculature, and, in severe cases, cranium. Patients who do not receive proper medical attention can suffer from bone and tissue loss and, if left untreated, death.Recent research about AFS has been limited to clinical observations because there are not currently animal models of this disease. Much of what is understood about the innate response to fungal infections in the nasal cavity is inferred from correlatives drawn from other tissue sites. For example, within the lungs, fungal conidium challenge stimulates leukocyte recruitment into the airspaces. The leukocytes, primarily macrophages and neutrophils, internalize resting or swollen conidia and use mechanisms such as respiratory burst to combat infections (2, 3, 10-12, 22, 24). It is believed that macrophages and neutrophils may have a similar response to fungi within the nasal cavity, although there have been no murine models that demonstrate this (18,20). Neutrophils help mediate the nasal inflammatory response in rodents coexposed to li...

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“…Increased plasma concentrations of different Th1 (TNF-alpha, IL-1, IL-6), Th2 (IL-5, IL-4) cytokines, and other inflammation-related mediators have been found in NP [2]. Eosinophils are the most abundant cell type, indeed high IgE concentrations have been found in NP [3].…”

Section: Introductionmentioning

confidence: 99%

Increased IL-6 and IL-4 in exhaled breath condensate of patients with nasal polyposis

Carpagnano

Carratù

Gelardi

et al. 2016

Monaldi Arch Chest Dis

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Background and Aim. Nasal polyposis (NP) occurs in about 1-4% of the worldwide population. Increased plasma concentrations of different pro-inflammatory cytokines have been observed in NP, and might be related to the pathogenesis of this syndrome.The present study was designed to investigate IL-6 and IL-4 concentrations in nasal and oral exhaled breath condensate of patients with early and advanced NP, and following polypectomy. Methods. Ten individuals with polyposis in early status, twenty-three patients affected by advanced status of NP and ten healthy controls were enrolled into the study. Exhaled breath condensate was collected by all individuals, according to a previous standardised method. An immunoassay kit was used to measure IL-6 and IL-4 levels. Results. Concentrations of oral and nasal exhaled IL- 6 and IL-4 were significantly higher in patients with early nasal polyposis and advanced nasal polyposis, compared to healthy controls. A statistically significant decrease of nasally but not of orally exhaled IL-6 (p<0.001) and IL-4 (p<0.05) was observed after polypectomy. Conclusions. We consider oral and nasal exhaled condensate of IL-6 and IL-4 as valid inflammatory and oxidative stress marker in patients with nasal polyposis.

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Cytokines in Nasal Polyposis, Acute and Chronic Sinusitis

Cited by 102 publications

References 28 publications

Histopatologia da lâmina própria do seio maxilar na rinossinusite crônica

Histopatologia da lâmina própria do seio maxilar na rinossinusite crônica

Role of Neutrophils in Preventing and Resolving Acute Fungal Sinusitis

Increased IL-6 and IL-4 in exhaled breath condensate of patients with nasal polyposis

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