Cytokines in Diabetes and Diabetic Complications

Rivero-González, A.; Martín-Izquierdo, Edduin; Marín-Delgado, Carlos; Rodríguez-Muñoz, Anabel; Navarro‐González, Juan F.

doi:10.1016/b978-0-12-804214-4.00006-3

Cited by 8 publications

(6 citation statements)

References 39 publications

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“…Cytokine treatment to promote wound healing is a new method for diabetic foot. The cytokines used mainly include fibroblast growth factor (FGF), epidermal growth factor (EGF), platelet growth factor (PGF), vascular endothelial cell growth factor (VEGF), cell colony-stimulating factor(G-CSF), and hepatocyte growth factor (HGF) [37].…”

Section: Current Therapy For Diabetic Footmentioning

confidence: 99%

“…ASCs are pluripotent stem cells that could differentiate directly into vascular endothelial cells, smooth muscle cells, and pericytes. These cells regulate vascular Vascular intervention therapy Suitable for severe ischemia; except for elderly and weak patients [34] Dressing adjuvant therapy Non-surgical therapy; physically assisted intervention; poor effect [32] Hyperbaric oxygen therapy [36] Vacuum suction therapy [36] Growth factor therapy Use multiple cytokines; good effect but expensive; new therapy [37] Stem cell therapy Significant treatment effect; wide range of applications; cutting-edge technology [38,40] growth, stabilization, and maturation through activation of TGF-β, angiopoietin-2, PDGF-B/PDGFR-β, Notch, and S1P/Edg signaling pathways [61,62]. Meanwhile, pericytes not only promote the appearance of endothelial progenitor cells but also maintain vascular integrity to form a vascular network [63].…”

Section: Differentiation Of Svfmentioning

confidence: 99%

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Therapeutic application of adipose-derived stromal vascular fraction in diabetic foot

et al. 2020

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Diabetic foot is one of the severest complications of diabetes. In severe cases, this disease may be lead to amputation or even death due to secondary infection and ischemic necrosis. Since the ineffectiveness of traditional therapy, autologous stem cell transplantation has been used to treat diabetic foot. This simple, safe, and effective therapy is expected to be applied and promoted in the future. In this review, we described the detailed pathogenesis of diabetic foot and the common clinical treatments currently used. We also revealed vascular remodeling as the potential mechanism of therapeutic functions of adipose-derived stromal vascular fraction (SVF) in treating diabetic foot.

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Section: Current Therapy For Diabetic Footmentioning

confidence: 99%

Section: Differentiation Of Svfmentioning

confidence: 99%

Therapeutic application of adipose-derived stromal vascular fraction in diabetic foot

et al. 2020

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“…The major threat of T2DM patients is associated with micro and macro vascular complications, which is considered as the major cause of morbidity and mortality [ 11 ]. Recently, low level of chronic inflammation has been found to have great implication on the onset and progression of T2DM [ 12 , 13 ]. Studies have shown that high level of inflammatory and anti-inflammatory cytokines such as IL-6 and IL-10 are detected in plasma of patients with T2DM, and thus, associated with its complication [ 14 – 17 ].…”

Section: Introductionmentioning

confidence: 99%

Association of IL-10 (− 1082 A/G) and IL-6 (− 174 G/C) gene polymorphism with type 2 diabetes mellitus in Ethiopia population

et al. 2021

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Background Interleukin (IL)-6 and IL-10 are the most important cytokine with pro and anti-inflammatory activities, respectively. Dysregulation of IL-6 and IL-10 are associated with increased risk of developing Type 2 Diabetes Mellitus (T2DM). Despite this, a fundamental understanding of both cytokine gene polymorphisms with its expression is critical in understanding of cellular mechanism of insulin resistance as well as T2DM intervention. Therefore, this study aimed to assess IL-6 (− 174 G/C) and IL-10 (− 1082 A/G) gene polymorphism, and its association with T2DM, North West Ethiopia. Methods A comparative cross-sectional study from January to May 2018 was conducted on study participants with T2DM and apparently healthy controls. Deoxyribonucleic acid (DNA) extraction and genotyping was carried out by using amplification refractory mutation system polymerase chain reaction to detect polymorphism of IL-6 and IL-10 gene at the position − 174 and − 1082, respectively. The logistic regression model was fitted to assess the association of between cytokine gene polymorphisms and T2DM. Odds ratio with 95% CI was determined to assess the presence and strength of association between the explanatory variables and outcome variable. A P-value < 0.05 was considered as statistically significant. Result Participants carrying the GG genotype of IL-6 (− 174) (OR (95% CI) = 4.61 (2.07–10.54) was a high likelihood of having T2DM compared to those carrying the CC and AA genotypes. AA and AG genotypes of IL-10 (− 1082) were at lower odd of developing T2DM compared to those carrying the GG genotype. In addition, individuals carrying the G allele of IL-6 (− 174) have 2.82-fold odds of developing T2DM compared to individuals carrying the C allele (OR (95% CI) =2.81 (1.78–4.50)). Conclusion Our study revealed that genetic polymorphisms of IL-6 (− 174) GG genotype is the potential host genetic risk factors to T2DM. While, IL-10 (− 1082) AA genotype is negatively associated with T2DM. Therefore, IL-6 (− 174) and IL-10 (− 1082) genetic variation may be considered as a biomarker for early screening and diagnosis of T2DM.

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“…81,82 So far, studies have confirmed that the major inflammatory cytokines (IL-1 family, IL-6 and TNF-α) are highly overexpressed in patients with T2DM. [83][84][85][86] The activation of these cytokines are involved in the promotion of pancreatic beta cell destruction, which in turn leads to the impairment of insulin secretion and resistance of insulin in the peripheral cells through the interference of insulin receptors. 87 In fact, the exact molecular mechanism of the development of insulin resistance is not clearly understood yet, but excess accumulation of fats and inflammation of adipose tissues are believed to be a major contributing factor for it.…”

Section: Role Of Caspase-1 In Diabetes Mellitusmentioning

confidence: 99%

<p>Role of Caspase-1 in the Pathogenesis of Inflammatory-Associated Chronic Noncommunicable Diseases</p>

Molla

Akalu

Geto

et al. 2020

JIR

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Caspase-1 is the first and extensively studied inflammatory caspase that is activated through inflammasome assembly. Inflammasome is a cytosolic formation of multiprotein complex that aimed to start inflammatory response against infections or cellular damages. The process leads to an auto-activation of caspase-1 and consequent maturation of caspase-1 target molecules such as interleukin (IL)-1β and IL-18. Recently, the role of caspase-1 and inflammasome in inflammatory-induced noncommunicable diseases (NCDs) like obesity, diabetes mellitus (DM), cardiovascular diseases (CVDs), cancers and chronic respiratory diseases have widely studied. However, their reports are distinct and even they have reported contrasting role of caspase-1 in the development and progression of NCDs. A few studies have reported that caspase-1/inflammasome assembley has a protective role in the initiation and progression of these diseases through the activation of the noncanonical caspase-1 target substrates like gasdermin-D and regulation of immune cells. Conversely, others have revealed that caspase-1 has a direct/indirect effect in the development and progression of several NCDs. Therefore, in this review, we systematically summarized the role of caspase-1 in the development and progression of NCDs, especially in obesity, DM, CVDs and cancers.

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Cytokines in Diabetes and Diabetic Complications

Cited by 8 publications

References 39 publications

Therapeutic application of adipose-derived stromal vascular fraction in diabetic foot

Therapeutic application of adipose-derived stromal vascular fraction in diabetic foot

Association of IL-10 (− 1082 A/G) and IL-6 (− 174 G/C) gene polymorphism with type 2 diabetes mellitus in Ethiopia population

<p>Role of Caspase-1 in the Pathogenesis of Inflammatory-Associated Chronic Noncommunicable Diseases</p>

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