Cytokines and chemokines in mild/asymptomatic cases infected with avian influenza A (H7N9) virus

Yang, Peng; Lou, Xiaomin; Zheng, Yang; Shi, Weixian; Li, Yang; Dong, Yusheng; Han, Yong; Pang, Xinghuo; Liu, Siqi; Wang, Quanyi

doi:10.1099/jmm.0.000333

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…However, other studies have indicated that IL-17-secreting cells may act as a “double-edged sword,” exacerbating pulmonary inflammation and immunopathology [21–23]. In some studies, H1N1 and H7N9 patients with severe infection showed elevated IL-17A serum levels, and it was proposed that IL-17A might exacerbate lung damage and contribute to the pathogenesis of disease [21, 24, 25]. All of these results highlight the need for further research to clarify the changes in Th17 cells, Tc17 cells, and IL-17A and their roles in influenza virus infection, especially in H7N9 virus infection.…”

Section: Introductionmentioning

confidence: 99%

Decreased Frequencies of Th17 and Tc17 Cells in Patients Infected with Avian Influenza A (H7N9) Virus

Bao

Cui

Wang

et al. 2019

Journal of Immunology Research

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The outbreak of avian influenza A (H7N9) virus infection, with a high mortality rate, has caused concern worldwide. Although interleukin-17- (IL-17-) secreting CD4+ T (Th17) and CD8+ T (Tc17) cells have been proven to play crucial roles in influenza virus infection, the changes and roles of Th17 and Tc17 cells in immune responses to H7N9 infection remain controversial. In this study, we found that the frequencies of Th17 and Tc17 cells among human peripheral blood mononuclear cells (PBMCs) as well as IL-17A protein and mRNA levels were markedly decreased in patients with acute H7N9 virus infection. A positive correlation was found between the serum IL-17A level and the frequency of these two cell groups. In vitro infection experiments revealed decreased Th17 and Tc17 cell frequency and IL-17A levels at various time points postinfection. In addition, Th17 cells were the predominant sources of IL-17A in PBMCs of patients infected with H7N9 virus. Taken together, our results indicate immune disorder in acute H7N9 infection and a restored Th17 and Tc17 cell frequency might serve as a biomarker for predicting recovery in patients infected with this virus.

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Section: Introductionmentioning

confidence: 99%

Decreased Frequencies of Th17 and Tc17 Cells in Patients Infected with Avian Influenza A (H7N9) Virus

Bao

Cui

Wang

et al. 2019

Journal of Immunology Research

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“…Reports have showed the presence of high levels of cytokines and chemokines, such as interleukin (IL)-6, IL-17, IL-2, monocyte chemotactic protein (MIP)-1, the monokine induced by gamma interferon (MIG), and macrophage inflammatory protein (MIP)-1b, in the serum of patients infected with H7N9 AIV. 86,87 Moreover, in patients with severe H7N9 infection, the expressed levels of IL-6 and IP-10 molecules are significantly higher than in asymptomatic patients with H7N9 infection. 86 However, a previous study using BALB/c and C57BL/6 mouse models assessed the pathogenicity of H7N9 virus, to examine the association of proinflammatory cytokines in lung injury and viral clearance.…”

Section: Pathogenesis Of H7n9 Influenza Infectionmentioning

confidence: 99%

Virus-induced pathogenesis, vaccine development, and diagnosis of novel H7N9 avian influenza A virus in humans: a systemic literature review

Mrc

et al. 2019

J Int Med Res

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H7N9 avian influenza virus (AIV) caused human infections in 2013 in China. Phylogenetic analyses indicate that H7N9 AIV is a novel reassortant strain with pandemic potential. We conducted a systemic review regarding virus-induced pathogenesis, vaccine development, and diagnosis of H7N9 AIV infection in humans. We followed PRISMA guidelines and searched PubMed, Web of Science, and Google Scholar to identify relevant articles published between January 2013 and December 2018. Pathogenesis data indicated that H7N9 AIV belongs to low pathogenic avian influenza, which is mostly asymptomatic in avian species; however, H7N9 induces high mortality in humans. Sporadic human infections have recently been reported, caused by highly pathogenic avian influenza viruses detected in poultry. H7N9 AIVs resistant to adamantine and oseltamivir cause severe human infection by rapidly inducing progressive acute community-acquired pneumonia, multiorgan dysfunction, and cytokine dysregulation; however, mechanisms via which the virus induces severe

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Novel Avian Influenza A Virus Infections of Humans

Uyeki

Peiris

2019

Infectious Disease Clinics of North America

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Cytokines and chemokines in mild/asymptomatic cases infected with avian influenza A (H7N9) virus

Cited by 4 publications

References 17 publications

Decreased Frequencies of Th17 and Tc17 Cells in Patients Infected with Avian Influenza A (H7N9) Virus

Decreased Frequencies of Th17 and Tc17 Cells in Patients Infected with Avian Influenza A (H7N9) Virus

Virus-induced pathogenesis, vaccine development, and diagnosis of novel H7N9 avian influenza A virus in humans: a systemic literature review

Novel Avian Influenza A Virus Infections of Humans

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