Decreased Frequencies of Th17 and Tc17 Cells in Patients Infected with Avian Influenza A (H7N9) Virus

Bao, Jiaqi; Cui, Dawei; Wang, Xiaochen; Zou, Qianda; Zhao, Dejian; Zheng, Shufa; Yu, Fei; Huang, Li Min; Dong, Yuejiao; Yang, Xianzhi; Xie, Guoliang; Chen, Weizhen; Chen, Yu

doi:10.1155/2019/1418251

Cited by 14 publications

(10 citation statements)

References 55 publications

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“…The IL-17A signaling in airway cells was downregulated in H7N9-infected NHBE cells in IPA analysis, and IL-17 was negatively expressed in our cytokine analysis. The result is consistent with other studies: Bao et al [25] claimed that the IL-17A protein and mRNA levels were decreased in patients with H7N9 infection and a restored Th17 and Tc17 cell frequency might serve as a biomarker for disease progression in patients infected with this virus.…”

Section: Discussionsupporting

confidence: 93%

Transcriptome Differences in Normal Human Bronchial Epithelial Cells in Response to Influenza A pdmH1N1 or H7N9 Virus Infection

Hsieh

Lin

Hsioa

et al. 2022

Cells

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Avian influenza A (H7N9) virus infections frequently lead to acute respiratory distress syndrome and death in humans. The emergence of H7N9 virus infections is a serious public health threat. To identify virus–host interaction differences between the highly virulent H7N9 and pandemic influenza H1N1 (pdmH1N1), RNA sequencing was performed of normal human bronchial epithelial (NHBE) cells infected with either virus. The transcriptomic analysis of host cellular responses to viral infection enables the identification of potential cellular factors related to infection. Significantly different gene expression patterns were found between pdmH1N1- and H7N9-infected NHBE cells. In addition, the H7N9 virus infection induced strong immune responses, while cellular repair mechanisms were inhibited. The differential expression of specific factors observed between avian H7N9 and pdmH1N1 influenza virus strains can account for variations in disease pathogenicity. These findings provide a framework for future studies examining the molecular mechanisms underlying the pathogenicity of avian H7N9 virus.

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Section: Discussionsupporting

confidence: 93%

Transcriptome Differences in Normal Human Bronchial Epithelial Cells in Response to Influenza A pdmH1N1 or H7N9 Virus Infection

Hsieh

Lin

Hsioa

et al. 2022

Cells

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“…A pilot study of patients with symptoms of respiratory tract infection demonstrated that the H3N2 influenza infection exhibited increased levels of Th17 cytokines concerned with pathogenesis and immune regulation (Antalis et al, 2019 ). In the patients infected with avian influenza A (H7N9) virus, the decreased Th17 and Tc17 cell levels are associated with disease severity however, the mechanism remains unknown (Bao et al, 2019 ). In PR8 H1N1 infected BALB/c mice the IL‐17A and IL‐17F mRNA levels were detected after 2 days postinfection.…”

Section: Role Of Il‐17 In Different Viral Infectionsmentioning

confidence: 99%

Interleukin‐17—A multifaceted cytokine in viral infections

Sahu

Biswas

Prajapati

et al. 2021

Journal Cellular Physiology

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Viral infections are a major threat to the human population due to the lack of selective therapeutic measures. The morbidity and mortality reported worldwide are very alarming against viral pathogens. The proinflammatory environment is required for viral inhibition by initiating the host immune response. The host immune response fights these pathogens by secreting different cytokines. Interleukin‐17 (IL‐17) a proinflammatory cytokine mainly produced by T helper type 17 cells, plays a vital role in the regulation of host immune response against various pathogens, including viruses. However, dysregulated production of IL‐17 induces chronic inflammation, autoimmune disorders, and may lead to cancer. Recent studies suggest that IL‐17 is not only involved in the antiviral immune response but also promotes virus‐mediated illnesses. In this review, we discuss the protective and pathogenic role of IL‐17 against various viral infections. A detailed understanding of IL‐17 during viral infections could contribute to improve therapeutic measures and enable the development of an efficient and safe IL‐17 based immunotherapy.

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“…IL-17 is a remarkably pleiotropic cytokine that plays a specific role in host immune response. A wide range of immune cell populations, such as Th17 cells , neutrophils, natural killer (NK) cells, mast cells, natural killer T (NKT) cells, CD8+ T cells and group 3 innate lymphoid cells produce IL-17 [7][8][9][10]. IL-17 has a crucial role in the preservation of tissue integrity and initiation of protective immune responses to infectious microorganisms, mostly at epithelial barrier sites [11].…”

Section: Discussionmentioning

confidence: 99%

Interleukin-17: Could it be a key player in COVID-19 infection severity?

Fathy

Elsheshtawy²,

Moneer³

et al. 2022

Microbes and Infectious Diseases

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Background: Exaggerated cytokines response with release of proinflammatory cytokines i.e., cytokine storm has been described with COVID-19 infection. This cytokine storm plays an important role in lung injury and development of acute respiratory distress syndrome (ARDS) in severely ill patients. One important cytokine that participates in the cytokine storm is interleukin (IL) -17. Aim of the study: Assess serum levels of IL-17 in COVID-19 patients and its correlation with disease severity. Methods: Sixty-six COVID-19 infected patients (33 moderate cases and 33 severe cases) and 20 healthy controls (HCs) were included in the study. Serum IL-17 level was assessed by ELISA in patients and HCs. Results: IL-17 levels were remarkably higher in patients' groups compared to HCs and also there was statistically significant difference between the patients' subgroups (p<0.0001). IL-17 was correlated with different laboratory and clinical parameters. At a cut-off value of >25 ng/ml, IL-17 was able to differentiate between the patients' groups and HCs with 93.94% sensitivity and 65% specificity. Conclusion: Serum IL-17 level correlates to more severe disease courses in COVID 19 patients. Higher levels were associated with devastating outcomes.

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Decreased Frequencies of Th17 and Tc17 Cells in Patients Infected with Avian Influenza A (H7N9) Virus

Cited by 14 publications

References 55 publications

Transcriptome Differences in Normal Human Bronchial Epithelial Cells in Response to Influenza A pdmH1N1 or H7N9 Virus Infection

Transcriptome Differences in Normal Human Bronchial Epithelial Cells in Response to Influenza A pdmH1N1 or H7N9 Virus Infection

Interleukin‐17—A multifaceted cytokine in viral infections

Interleukin-17: Could it be a key player in COVID-19 infection severity?

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