Cytokine Storm Modulation in COVID-19: A Proposed Role for Vitamin D and DPP-4 Inhibitor Combination Therapy (VIDPP-4i)

Pinheiro, Marcelo Maia; Fabbri, Andrea; Infante, Marco

doi:10.2217/imt-2020-0349

Cited by 36 publications

(31 citation statements)

References 111 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The interaction(s) between vitamin D and its role in general immune status (as well as specific associations with COVID-19 severity) merit further studies. Early research results on these purported associations support further exploration of this potential factor on disease outcomes and virulence [ 16 , 17 , 18 , 19 ]. Moreover, associations between COVID-19 mortality and diet/lifestyle factors, such as nutritional status or consumption of seafood, warrant further exploration.…”

Section: Discussionmentioning

confidence: 94%

Spatial Variability in COVID-19 Mortality

Bossak

Turk

2021

IJERPH

View full text Add to dashboard Cite

COVID-19 emerged as a global pandemic in the spring of 2020. Since that time, the disease has resulted in approximately 150 million cases and 3 million deaths worldwide. However, there is significant spatial variation in the rate of mortality from COVID-19. Here, we briefly explore spatial variations in COVID-19 mortality by country groupings and propose possible explanations for the differences observed. Specifically, we find that there is a statistically significant difference in COVID-19 mortality between countries grouped into categories based on (1) developed, primarily western diets and healthcare systems; (2) “Scandinavian” countries with advanced healthcare systems and generally anti-inflammatory diets, and (3) developing countries. We do not infer causality but believe that the observed associations provide hypotheses for future research investigations. Moreover, our results add further evidence to support additional exploration of vitamin D exposure/status and COVID-19 mortality.

show abstract

Section: Discussionmentioning

confidence: 94%

Spatial Variability in COVID-19 Mortality

Bossak

Turk

2021

IJERPH

View full text Add to dashboard Cite

show abstract

“…Figure 2 depicts the comparison of the vitamin D level measured between moderate and severe COVID-19 patients at 1 year before diagnosis and at admission. Median serum 25-hydroxyvitamin D measured one year before COVID-19 decreased with increasing COVID-19 severity (22 [15-32] vs. 19 [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26], P=0.009). Similar results were obtained when comparing median serum 25-hydroxyvitamin D at admission between moderate and severe patients (20 [12][13][14][15][16][17][18][19][20][21][22][23][24][25]) vs. 15 [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23]…”

Section: Resultsmentioning

confidence: 99%

Association of vitamin D deficiency with COVID-19 severity and mortality in Iranian people: a prospective observational study

Fatemi

Ardehali

Eslamian³

et al. 2021

Acute Crit Care

View full text Add to dashboard Cite

Background: As the coronavirus disease 2019 (COVID-19) pandemic continues to escalate, it is important to identify the prognostic factors related to increased mortality and disease severity. To assess the possible associations of vitamin D level with disease severity and survival, we studied 248 hospitalized COVID-19 patients in a single center in a prospective observational study from October 2020 to May 2021 in Tehran, Iran. Methods: Patients who had a record of their 25-hydroxyvitamin D level measured in the previous year before testing positive with COVID-19 were included. Serum 25-hydroxyvitamin D level was measured upon admission in COVID-19 patients. The associations between clinical outcomes of patients and 25-hydroxyvitamin D level were assessed by adjusting for potential confounders and estimating a multivariate logistic regression model. Results: The median (interquartile range) age of patients was 60 years (44–74 years), and 53% were male. The median serum 25-hydroxyvitamin D level prior to admission decreased with increasing COVID-19 severity (P=0.009). Similar findings were obtained when comparing median serum 25-hydroxyvitamin D on admission between moderate and severe patients (P=0.014). A univariate logistic regression model showed that vitamin D deficiency prior to COVID-19 was associated with a significant increase in the odds of mortality (odds ratio, 2.01; P=0.041). The Multivariate Cox model showed that vitamin D deficiency on admission was associated with a significant increase in risk for mortality (hazard ratio, 2.35; P=0.019).Conclusions: Based on our results, it is likely that deficient vitamin D status is associated with increased mortality in COVID-19 patients. Thus, evaluating vitamin D level in COVID-19 patients is warranted.

show abstract

“…Obserwuje się również, że witamina D3 wykazuje zdolności immunomodulacyjne i przeciwzapalne. Na podstawie przeprowadzonych badań wykazano, że zmniejsza ona infiltrację leukocytów do miejsc zapalnych oraz obniża poziom produkcji cytokin i chemokin prozapalnych [14]. Dodatkowo ustalono plejotropowy efekt kalcytriolu na aktywność komórek immunologicznych.…”

Section: Wprowadzenie I Cel Pracyunclassified

Vitamin D3 – a fundamental component of human health and a potential supplement for COVID-19 prevention and therapy

Sawicki¹,

Skawiński²

2021

Med Og Nauk Zdr.

View full text Add to dashboard Cite

Wprowadzenie i cel pracy. Witamina D3 jest jednym z najbardziej istotnych związków endogennych syntetyzowanych w organizmie człowieka. Pierwotnie jej niedobór powiązano z występowaniem krzywicy u dzieci. Jednakże liczne badania przeprowadzone w ciągu ostatnich dziesięcioleci wskazały, że witamina D3 ma dużo większe znaczenie, niż wcześniej przypuszczano. Celem niniejszej pracy była analiza dostępnej literatury naukowej dotyczącej witaminy D3 i jej wpływu na zdrowie człowieka. Metody przeglądu. W celu przeszukiwania bazy danych Pubmed użyto następujących kombinacji słów kluczowych: ["vitamin D"] + ["synthesis", "metabolism", "receptor", "epidemiology", "deficiency", "SARS-CoV-2"]. Po zastosowaniu kryteriów wykluczających do przeglądu wybrano 67 publikacji. Opis stanu wiedzy. Około 90% witaminy D3 jest wytwarzane w skórze w rezultacie ekspozycji na promieniowanie UVB. Pozostała część jest dostarczana z żywnością lub suplementami diety. Postuluje się, że niedobór witaminy D3 jest obecnie jednym z najbardziej palących problemów zdrowotnych. Dane literaturowe wskazują, że niedobór witaminy D3 poważnie zaburza homeostazę organizmu i zwiększa ryzyko powstawania niektórych nowotworów, chorób sercowo-naczyniowych, a także cukrzycy typu 2. W związku z wybuchem pandemii koronawirusa SARS-CoV-2 w 2019 roku rozpoczęto badania kliniczne dotyczące wpływu witaminy D3 na podatność na infekcję i przebieg choroby. Stwierdzono jej korzystny wpływ w przeciwdziałaniu zakażeniom i łagodzeniu skutków COVID-19. Podsumowanie. Wraz z postępem medycyny zrozumiano, jak ważna dla prawidłowego funkcjonowania organizmu jest witamina D3 i jakie konsekwencje zdrowotne powoduje jej niedobór. Dlatego z punktu widzenia zdrowia publicznego istotne jest powszechne uświadomienie społeczeństwa o znaczeniu tej witaminy dla zdrowia i zaletach jej regularnego przyjmowania.

show abstract

Cytokine Storm Modulation in COVID-19: A Proposed Role for Vitamin D and DPP-4 Inhibitor Combination Therapy (VIDPP-4i)

Cited by 36 publications

References 111 publications

Spatial Variability in COVID-19 Mortality

Spatial Variability in COVID-19 Mortality

Association of vitamin D deficiency with COVID-19 severity and mortality in Iranian people: a prospective observational study

Vitamin D3 – a fundamental component of human health and a potential supplement for COVID-19 prevention and therapy

Contact Info

Product

Resources

About