Cytokine Profile of Periodontal Pocket Contents in Estimating Theseverity and Efficiency of Treatment Offered to Patients With Refractory Periodontitis

Булкина, Н. В.; Моргунова, В. М.; Osipova, Yulia; Pronina, Nadezhda; Полосухина, Е. Н.; Guseva, Olga; Kropotina, A. Yu .; Konnov, Valeriy

doi:10.35630/2199-885x/2019/9/2/133

Cited by 4 publications

(4 citation statements)

References 3 publications

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“…Modern studies [1][2][3][4][5][6][7][8] reveal that the general pathomorphological pattern that determines the course and prognosis of any chronic process, including periodont inflammatory diseases, is due to the intensity of cell renewal processes, which can be employed both for early diagnosis of the disease, and to for developing its forecast. The involvement of mast cells in inflammation regulation and tissues proliferation explains the increased interest that researchers take in studying their role in periodont inflammatory diseases [10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Proliferation of Histamine and Serotonin in Mast Cells of Patients With Inflammatory Periodontal Disease in the Course Oft

Khabibullina¹,

Osipova²,

Булкина³

et al. 2020

AREM

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The purpose of this study was to examine the indicators of cell proliferation, apoptosis, as well as the quantitative features of histamine and serotonin producing gum mast cells in patients with chronic gingivitis and periodontitis through the treatment dynamics. The study has shown that gingivitis is associated with hyperplasia and hyperfunction of the gum mast cells general population producing histamine, as well as with an increase in cell proliferation. Periodontitis revealed an increase in apoptosis, a decrease in periodontal proliferation due to hyperplasia and hyperfunction of the total mast cell population secreting histamine and serotonin.

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Section: Introductionmentioning

confidence: 99%

Proliferation of Histamine and Serotonin in Mast Cells of Patients With Inflammatory Periodontal Disease in the Course Oft

Khabibullina¹,

Osipova²,

Булкина³

et al. 2020

AREM

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“…Inflammatory periodontal diseases represent multifactorial infectious pathology caused by the body' s immune reaction in response to exposure to the oral biofilm [9,10,12]. High prevalence of inflammatory periodontal diseases in young people [1,3,7], low level of oral hygiene despite a wide selection of constantly improving hygiene products [8] along with the instability of treatment results [5], adverse outcomes and long-term consequences affecting the health determine significance and urgency of this problem in the modern dentistry and healthcare system [4,6,11,12].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of a plant-based dental gel for chronic simple marginal gingivitis: a clinical trial

Isaeva¹,

Averyanov²,

Iskhakov³

et al. 2020

AREM

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High prevalence of inflammatory periodontal diseases in young people along with unfavourable outcomes and long-term consequences cause great damage to health, thereby determining the importance and urgency of this problem in modern dentistry. Herein, we introduced a gel based on sanguiritrin, medicinal extracts of calendula and yarrow, and evaluated its effectiveness in the treatment of chronic simple marginal gingivitis in the clinical study involving 45 patients aged 18 to 23 years (26 females and 19 males). In the treatment group (23 patients), after professional oral hygiene and correction of hygiene skills, the dental gel based on sanguiritrin, medicinal extracts of calendula and yarrow was applied as part of complex therapy, while in the control group (22 patients) the Cholisal gel was used. The data obtained from hygienic and periodontal indices following the treatment (OHI-S — 0.39±0.03; PBI — 1.12±0.06; PMA — 16.4±1.31%) showed clinical anti-inflammatory efficacy of the introduced dental gel in the treatment of gingivitis, while positive indices dynamics of the dental status (OHI-S — 0.64±0.03; PBI — 0.42±0.03; PMA — 9.92±1.42%) evaluated in 3rd, 6th and 12th months after the therapy indicated of the stability of obtained results.

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“…The pathogenesis, diagnosis and treatment of inflammatory periodontal diseases are an urgent issue faced by dentistry [1][2][3][4][5][6]. Antibacterial therapy is an integral part of comprehensive treatment offered to patients with generalized periodontitis [7].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Oral Fluid Enzymes Activity in Patients With Periodontitis Undergoing Complex Antibiotic Therapy

Булкина¹,

Guseva²,

Osipova³

et al. 2020

AREM

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Antibacterial therapy is the fundamental point in comprehensive treatment of patients with generalized periodontitis. The choice of an antibacterial drug, in view of its maximum effectiveness, is the key to successful pre-surgical preparation of patients with periodontitis to rapid post-surgery rehabilitation and remission maintenance. Our clinical study aims to analyze the activity of oral fluid enzymes (lactate dehydrogenase (LDH), alkaline phosphatase (ALP)) in patients treated with fluoroquinolones. 60 patients were allocated to groups. Each group had a 7-day course of one from four antibiotics: ciprofloxacin (250 mg; 2 times a day); ofloxacin (200 mg; 2 times a day); pefloxacin (400 mg; 2 times a day) and lincomycin hydrochloride (500 mg; 2 times a day). Ciprofloxacin was found to have the highest effect on the LDH and ALP suppression.

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Cytokine Profile of Periodontal Pocket Contents in Estimating Theseverity and Efficiency of Treatment Offered to Patients With Refractory Periodontitis

Cited by 4 publications

References 3 publications

Proliferation of Histamine and Serotonin in Mast Cells of Patients With Inflammatory Periodontal Disease in the Course Oft

Proliferation of Histamine and Serotonin in Mast Cells of Patients With Inflammatory Periodontal Disease in the Course Oft

Efficacy of a plant-based dental gel for chronic simple marginal gingivitis: a clinical trial

Analysis of Oral Fluid Enzymes Activity in Patients With Periodontitis Undergoing Complex Antibiotic Therapy

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