Cytokine Levels in the Serum of Patients with Chronic Kidney Insufficiency Before and After Hemodialysis

Romanova, Yulia; Markelova, Maria; Laikov, Alexander; Фахрутдинова, Л И; Hasanova, Milausha; Malanin, Sergey; Чернов, В. М.; Салафутдинов, И. И.; Khaiboullina, Svetlana F.

doi:10.1007/s12668-016-0379-6

Cited by 2 publications

(3 citation statements)

References 17 publications

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“…Our results correlate well with the data obtained by other researchers in that blood APOA4, AAT, VIL1, complement component and cytokine concentrations increased in patients with renal disorders [8,[11][12][13][14]28,[32][33][34]43,[69][70][71]. Moreover, we found elevated serum concentrations of potential oncomarkers (CUL5, antigen KI-67) and other intracellular proteins (NKRF, CAPRI, IGSF22, APPBP2, CCD171 and CCD43) in patients with CKD.…”

Section: Discussionsupporting

confidence: 92%

“…Increased blood serum levels of cytokines such as IL-4, IL-5, IL-6, IL-10 and IL-13, G-CSF, eotaxin and MIP-1β might indicate the activation of Th2 cells responsible for the development of humoral immune responses [66,67]. It should be noted that increased blood levels of cytokines involved in the activation of Th1 cells as well as IL-2, GM-CSF, TNF-α, IL-12, RANTES, MIP-1α and IL-18 were previously observed in patients with CKD [68,69]. Simultaneous activation of Th1 and Th2 cells was shown in various renal pathologies [69][70][71] and in a number of other diseases [72][73][74].…”

Section: Discussionmentioning

confidence: 89%

“…It should be noted that increased blood levels of cytokines involved in the activation of Th1 cells as well as IL-2, GM-CSF, TNF-α, IL-12, RANTES, MIP-1α and IL-18 were previously observed in patients with CKD [68,69]. Simultaneous activation of Th1 and Th2 cells was shown in various renal pathologies [69][70][71] and in a number of other diseases [72][73][74]. Moreover, significantly increased IL-9 might suggest ongoing differentiation of Т-cells into a Th9 population [73].…”

Section: Discussionmentioning

confidence: 99%

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Proteomic Analysis of Human Serum from Patients with Chronic Kidney Disease

et al. 2020

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Chronic kidney disease (CKD) is an important public health problem in the world. The aim of our research was to identify novel potential serum biomarkers of renal injury. ELISA assay showed that cytokines and chemokines IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12 (p70), IL-13, IL-15, IL-17, Eotaxin, FGFb, G-CSF, GM-CSF, IP-10, MCP-1, MIP-1α, MIP-1β, PDGF-1bb, RANTES, TNF-α and VEGF were significantly higher (R > 0.6, p value < 0.05) in the serum of patients with CKD compared to healthy subjects, and they were positively correlated with well-established markers (urea and creatinine). The multiple reaction monitoring (MRM) quantification method revealed that levels of HSP90B2, AAT, IGSF22, CUL5, PKCE, APOA4, APOE, APOA1, CCDC171, CCDC43, VIL1, Antigen KI-67, NKRF, APPBP2, CAPRI and most complement system proteins were increased in serum of CKD patients compared to the healthy group. Among complement system proteins, the C8G subunit was significantly decreased three-fold in patients with CKD. However, only AAT and HSP90B2 were positively correlated with well-established markers and, therefore, could be proposed as potential biomarkers for CKD.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

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Proteomic Analysis of Human Serum from Patients with Chronic Kidney Disease

et al. 2020

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Adropin and Spexin Hormones Regulate the Systemic Inflammation in Adenine-Induced Chronic Kidney Failure in Rat

Memi

Yazgan

2021

Chinese Journal of Physiology

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Chronic kidney disease is one of the major global health problems. Chronic renal failure is stimulated by many cytokines and chemokines. Adropin and spexin (SPX) are peptides hormones. These peptides could affect inflammatory conditions, but this is unclear. Due to the limited information, we planned to investigate the impact of adropin and SPX hormones on systemic inflammation in adenine induced chronic kidney failure rat model. Chronic kidney failure was induced by administering adenine hemisulfate. Renal functions were measured by an autoanalyzer. Granulocyte colony-stimulating factor (G-CSF), interferon-gamma (IFN-γ), interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-10, IL-12, IL-13, IL-17A, tumor necrosis factor-alpha, Eotaxin, growth-regulated oncogene-alpha, IP-10, monocyte chemoattractant protein (MCP)-1, MCP-3, macrophage inflammatory protein (MIP)-1α, MIP-2, and RANTES levels were determined by Luminex. We observed an increase in 24-h urine volume and serum creatinine. Blood urea nitrogen (BUN) and urine protein levels were also significantly higher in the chronic kidney failure (CKF) group. Urine protein and 24-h urine volume were reduced with adropin and SPX treatments. Furthermore, G-CSF, IFN-γ, IL-4, IL-5, IL-10, IL-12, IL-17A, and GRO-α significantly increased by CKF induction; however, these cytokines and chemokines significantly decreased by adropin treatment in the CKF group. Furthermore, adropin increased IP-10, MCP-1, MIP-1α, and MIP-2 levels. In addition, SPX treatment had a more limited effect, decreasing only G-CSF, IFN-γ, and IL-5 levels. The combined adropin + SPX treatment significantly reduced G-CSF, IFN-γ, IL-4, IL-5, IL-12, and IL-17A. Furthermore, IP-10, MCP-1, MCP-3, and MIP-2 were significantly increased by these combined treatments. Our findings indicate that renal functions and inflammatory response were modulated by adropin and SPX peptides. These peptides may have protective effects on systemic inflammation and renal failure progression.

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Cytokine Levels in the Serum of Patients with Chronic Kidney Insufficiency Before and After Hemodialysis

Cited by 2 publications

References 17 publications

Proteomic Analysis of Human Serum from Patients with Chronic Kidney Disease

Proteomic Analysis of Human Serum from Patients with Chronic Kidney Disease

Adropin and Spexin Hormones Regulate the Systemic Inflammation in Adenine-Induced Chronic Kidney Failure in Rat

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