Adropin and Spexin Hormones Regulate the Systemic Inflammation in Adenine-Induced Chronic Kidney Failure in Rat

Memi, Gülsün; Yazgan, Burak

doi:10.4103/cjp.cjp_13_21

Cited by 8 publications

(2 citation statements)

References 51 publications

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“…Although adropin has been previously investigated in numerous animal and clinical studies as a biomarker of T2DM-induced nephropathy, endothelial dysfunction, arterial stiffening, and atherosclerosis [ 24 , 47 , 48 , 49 ], there are scarce studies regarding its predictive ability in the HF population with several concomitant diseases, including T2DM and obesity [ 50 ]. Accumulating data suggest that adropin exerts metabolic regulation of gluconeogenesis, ketone production, and lipid oxidation in the myocardium, liver, and skeletal muscle [ 51 , 52 ].…”

Section: Discussionmentioning

confidence: 99%

Adropin Predicts Chronic Kidney Disease in Type 2 Diabetes Mellitus Patients with Chronic Heart Failure

Berezina¹,

Obradovic

Boxhammer

et al. 2023

JCM

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Adropin is a multifunctional secreted protein, which is involved in the metabolic modulation of the heart-brain-kidney axis in heart failure (HF). The aim of the study was to detect the plausible predictive value of serum levels of adropin for chronic kidney disease (CKD) grades 1–3 in type 2 diabetes mellitus (T2DM) patients with chronic HF. We enrolled 417 T2DM individuals with chronic HF and subdivided them into two groups depending on the presence of CKD. The control group was composed of 25 healthy individuals and 30 T2DM patients without HF and CKD. All eligible patients underwent an ultrasound examination. Adropin was detected by ELISA in blood samples at the study baseline. We found that adropin levels in T2DM patients without HF and CKD were significantly lower than in healthy volunteers, but they were higher than in T2DM patients with known HF. The optimal cut-off point for adropin levels was 2.3 ng/mL (area under the curve [AUC] = 0.86; 95% CI = 0.78–0.95; sensitivity = 81.3%, specificity = 77.4%). The multivariate logistic regression adjusted for albuminuria/proteinuria showed that serum levels of adropin <2.30 ng/mL (OR = 1.55; p = 0.001) independently predicted CKD. Conclusions: Low levels of adropin in T2DM patients with chronic CH seem to be an independent predictor of CKD at stages 1–3.

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Section: Discussionmentioning

confidence: 99%

Adropin Predicts Chronic Kidney Disease in Type 2 Diabetes Mellitus Patients with Chronic Heart Failure

Berezina¹,

Obradovic

Boxhammer

et al. 2023

JCM

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show abstract

“…The results of the present study demonstrated that adropin expression in lung tissue and serum in AP-ALI models ws decreased, supporting the likelihood of its involvement in the progression of AP-ALI. Adropin can regulate renal function and inflammatory responses, exerting a protective effect on the progression of systemic inflammation and renal failure ( 15 ). Adropin has been shown to inhibit inflammation by reducing the levels of pro-inflammatory cytokines and IL-6 in tissues ( 16 ).…”

Section: Discussionmentioning

confidence: 99%

Adropin attenuates pancreatitis‑associated lung injury through PPARγ phosphorylation‑related macrophage polarization

Ding,

Liu,

Gao

et al. 2023

Int J Mol Med

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Acute pancreatitis (AP)-associated lung injury (ALI) is a critical complication of AP. Adropin is a regulatory protein of immune metabolism. The present study aimed to explore the immunomodulatory effects of adropin on AP-ALI. For this purpose, serum samples of patients with AP were collected and the expression levels of serum adropin were detected using ELISA. Animal models of AP and adropin knockout (Adro-KO) were constructed, and adropin expression in serum and lung tissues was investigated. The levels of fibrosis and apoptosis were evaluated using hematoxylin and eosin staining, Masson's staining and immunohistochemistry of in lung tissue. M1/M2 type macrophages in the lungs were detected using immunofluorescence staining, western blot analysis and reverse transcription-quantitative PcR. As shown by the results, adropin expression was decreased in AP. In the Adro-KO + L-arginine (L-Arg) group, macrophage infiltration, fibrosis and apoptosis were increased. The expression of peroxisome proliferator-activated receptor γ (PPARγ) was downregulated, and the macrophages exhibited a trend towards M1 polarization in the Adro-KO + L-Arg group. Adropin exogenous supplement attenuated the levels of fibrosis and apoptosis in the model of AP. Adropin exogenous supplement also increased PPARγ expression by the regulation of the phosphorylation levels, which was associated with M2 macrophage polarization. On the whole, the findings of the present study suggest that adropin promotes the M2 polarization of lung macrophages and reduces the severity of AP-ALI by regulating the function of PPARγ through the regulation of its phosphorylation level.

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The cross‐cultural adaptation and psychometric evaluation of a learned helplessness scale for maintenance hemodialysis patients in China (LHS‐MHD‐C)

Xie

Zhou

Sun

et al. 2023

Research in Nursing & Health

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Learned helplessness (LH) is an important concept in nursing. This study aimed to adapt and translate the Arthritis Helplessness Index scale into a Chinese version of an LH scale for maintenance hemodialysis patients in China (LHS‐MHD‐C), and to validate its psychometric properties. Data collected included LHS‐MHD‐C, as well as the Hospital Depression Scale (HADS‐D), and the Beck Hopelessness Scale (BHS) for assessing LHS‐MHD‐C's criterion validity (predictive and concurrent, respectively). The expert consultation and the pilot study demonstrated semantic and conceptual equivalence and content validity (except for Item 3, the item content validity ranged from 0.82 to 1, and the scale content validity was 0.95). An exploratory factor analysis (n = 146) eliminated three items and accepted 11 items for the two factors, explaining 63.87% of the total variance. A CFA (n = 218) showed that the two‐factors structure was consistent with the LH theory. The LHS‐MHD‐C can distinguish between maintenance hemodialysis (MHD) patients of different ages, education, working status, monthly income, and MHD duration. The scale had good concurrent validity with the BHS (r = .78, p < 0.01). Using the HADS‐D as a criterion, the LHS‐MHD‐C showed a sensitivity of 86.2% and a specificity of 96.8%. A total score of 36.5 may be the best cut‐off value for predicting MHD patients' depression. The scale showed good reliabilities (Cronbach's α value of .759, test–retest reliability of 0.772, and split‐half reliability of 0.774). This study found that the LHS‐MHD‐C is a reliable and valid scale for assessing Chinese MHD patients' helplessness.

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Adropin and Spexin Hormones Regulate the Systemic Inflammation in Adenine-Induced Chronic Kidney Failure in Rat

Cited by 8 publications

References 51 publications

Adropin Predicts Chronic Kidney Disease in Type 2 Diabetes Mellitus Patients with Chronic Heart Failure

Adropin Predicts Chronic Kidney Disease in Type 2 Diabetes Mellitus Patients with Chronic Heart Failure

Adropin attenuates pancreatitis‑associated lung injury through PPARγ phosphorylation‑related macrophage polarization

The cross‐cultural adaptation and psychometric evaluation of a learned helplessness scale for maintenance hemodialysis patients in China (LHS‐MHD‐C)

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