Cytokine induction by 41.8 °C whole body hyperthermia

Hi, Robins; Kutz, M; Wiedemann, G. J.; Dm, Katschinski; Paul, Devchand; Grosen, Elizabeth A.; Cl, Tiggelaar; Spriggs, David R.; Gillis, W.; d'Oleire, F

doi:10.1016/0304-3835(95)03976-4

Cited by 90 publications

(42 citation statements)

References 11 publications

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“…In this study, we confirm previous findings by us and others demonstrating an enhancing effect of WBH treatment on the release of different cytokines in humans (2,35). As in our previous study (2), we observed a prolonged increase in serum levels of TNF-␣ in patients undergoing high-temperature WBH treatment.…”

Section: Ajp-regul Integr Comp Physiolsupporting

confidence: 93%

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Patients with solid tumors treated with high-temperature whole body hyperthermia show a redistribution of naive/memory T-cell subtypes

Atanackovic

Pollok

Faltz

et al. 2006

American Journal of Physiology-Regulatory, Integrative and Comp

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Section: Ajp-regul Integr Comp Physiolsupporting

confidence: 93%

“…WBH, as well as strenuous exercise, have been shown to be capable of increasing plasma levels of numerous cytokines, such as TNF-␣, IL-6, and IL-8 (2,27,29,35). Furthermore, WBH causes an increase in serum levels of sIL-2R, a marker for T-cell activation in humans (2).…”

Section: Central Memory T Cells Numbers Of Cd45ramentioning

confidence: 99%

Patients with solid tumors treated with high-temperature whole body hyperthermia show a redistribution of naive/memory T-cell subtypes

Atanackovic

Pollok

Faltz

et al. 2006

American Journal of Physiology-Regulatory, Integrative and Comp

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“…The similar results have been reported in mouse C2C12 myoblasts and skeletal muscle [56]. In humans, it has been also reported that therapeutic hyperthermia, which is used for cancer treatment (41.8ºC core temperature for 30 min), induces a striking elevation of IL-6 [57]. Recently, Ye et al [22] showed that TRPV4 is involved directly in adipocyte functions such as IL-6 secretion.…”

Section: Discussionsupporting

confidence: 77%

Thermo-Sensitive Transient Receptor Potential Vanilloid (TRPV) Channels Regulate IL-6 Expression in Mouse Adipocytes

Oguri¹,

Takano²

2015

Cardiol Pharmacol

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IntroductionObesity exacts a continuing toll on public health and is a wellknown risk factor for diabetes, hypertension, hyperlipidemia, and cardiovascular diseases [1][2][3][4]. It is evident that not only hypertrophy of adipocytes and increase of fat deposit but also proliferation of preadipocytes and differentiation from pre-adipocytes to adipocytes have important roles for forming obesity. The most intensive and clinical interventions to prevent obesity have been primarily directed to decrease excessive amounts of fat tissue by a change in the balance between intake and expenditure of energy using daily exercise and diet control. On the other hand, the inverse correlation between body mass index (BMI) and the average temperature of January exists, and BMI is low when the temperature is high [5]. In addition, when rats were fed under low or high temperature environment, the amount of subcutaneous fat in rats fed under high temperature was significantly low, compared with that under the low temperature [5]. Thus, hyperthermia may affect adipose cell functions, then adipogenesis, and provides a therapeutic or preventive modality against obesity-related diseases. However, there are few reports concerning the direct effects of hyperthermia stimulation on adipocytes and its underlying mechanism. AbstractBackground: Hyperthermia may affect adipose cell functions and then adipogenesis. Thermo-sensitive transient receptor potential (TRPs) proteins such as TRPV1-4 play vital roles in cellular functions. We investigated the expression of thermo-sensitive TRPVs and their roles on IL-6 production in mouse 3T3-L1 preadipocytes and differentiated adipocytes.

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“…There is some evidence that supports cytokine induction following whole body heat shock (52). Furthermore, there is evidence that the activation of ERK MAPKs in response to stress may be mediated by an autocrine release of growth factors or cytokines then acting via their specific receptors to stimulate the classical Ras-dependent ERK MAPK pathway (11,12).…”

Section: Discussionmentioning

confidence: 99%

The Mechanism of Heat Shock Activation of ERK Mitogen-activated Protein Kinases in the Interleukin 3-dependent ProB Cell Line BaF3

Bogoyevitch

2000

Journal of Biological Chemistry

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We have investigated heat shock stimulation of MAPK cascades in an interleukin 3-dependent cell line, BaF3. Following exposure to 42°C, the stress-activated JNK MAPKs were phosphorylated and activated, but p38 MAPKs remained unaffected. Surprisingly, heat shock also activated ERK MAPKs in a potent (>60-fold), delayed (>30 min), and sustained (>120 min) manner. These characteristics suggested a novel mechanism of ERK MAPK activation and became the focus of this study. A MEK-specific inhibitor, PD98059, inhibited heat shock ERK MAPK activation by >75%. Surprisingly, a role for Ras in the heat shock response was eliminated by the failure of a dominant-negative Ras Asn-17 mutant to inhibit ERK MAPK activation and the failure to observe increases in Ras⅐GTP. Heat shock also failed to stimulate activation of A-, B-, and c-Raf. Instead, a serine/threonine phosphatase inhibitor, okadaic acid, activated ERK MAPK in a similar manner to heat shock. Furthermore, pretreatment with suramin, generally recognized as a broad range inhibitor of growth factor receptors, inhibited both okadaic acid-stimulated and heat shock-stimulated ERK MAPK activity by >40%. Inhibiting ERK MAPK activation during heat shock with PD98059 enhanced losses in cell viability. These results demonstrate Ras-and Raf-independent ERK MAPK activation maintains cell viability following heat shock.

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Cytokine induction by 41.8 °C whole body hyperthermia

Cited by 90 publications

References 11 publications

Patients with solid tumors treated with high-temperature whole body hyperthermia show a redistribution of naive/memory T-cell subtypes

Patients with solid tumors treated with high-temperature whole body hyperthermia show a redistribution of naive/memory T-cell subtypes

Thermo-Sensitive Transient Receptor Potential Vanilloid (TRPV) Channels Regulate IL-6 Expression in Mouse Adipocytes

The Mechanism of Heat Shock Activation of ERK Mitogen-activated Protein Kinases in the Interleukin 3-dependent ProB Cell Line BaF3

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