Cytokine-induced secretion of monocyte chemotactic protein-1 by human endometriotic cells in culture

Akoum, Ali; Lemay, André; Brunet, Chantal; Hébert, Jacques

doi:10.1016/0002-9378(95)90578-2

Cited by 76 publications

(51 citation statements)

References 22 publications

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“…According to our and other previous studies, immune cells-derived cytokines, such as IL-1, may alone or in concert with estrogens, enhance the capability of ectopic endometrial cells to implant and develop into the host tissue, by inducing an angiogenic phenotype and stimulating the production of proinflammatory, growth, and tissue remodeling factors (Akoum et al 2000, 2002, Taylor et al 2002, Seli & Arici 2003, Wu & Ho 2003, Osteen et al 2004. Furthermore, our and other previous studies showed augmented sensitivity of endometriotic cells to the biological actions of IL-1 (Akoum et al 1995, 2002, Lebovic et al 2000, which may account for their ability to favor their own ectopic growth.…”

Section: Discussionsupporting

confidence: 68%

“…The inhibitory activity of IL-1ra was even shown to be enhanced by soluble IL-1RII and hindered by soluble IL-1RI (Burger et al 1995). According to our and other previous data, endometriotic cells are highly sensitive and responsive to IL-1 (Akoum et al 1995(Akoum et al , 2000(Akoum et al , 2002, and secrete increased levels of angiogenic factors compared with endometrial cells from normal women (Lebovic et al 2000). Also, IL-1RI is, in contrast to the decoy inhibitory IL-1RII, slightly released in the culture medium of endometrial and endometriotic cells (personal data).…”

Section: Il-1ri Expression In Ectopic Endometrial Tissuesupporting

confidence: 72%

“…Increased concentrations of the cytokine were found in the peritoneal fluid of women with endometriosis (Fakih et al 1987, Mori et al 1992, Taketani et al 1992 as well as in ectopic endometrial implants (Bergqvist et al 2001). In our previous studies, endometriotic cells showed a marked secretion of monocyte chemotactic protein-1 (MCP-1), regulated on activation normal T-cell expressed and secreted (RANTES), IL-6 and IL-8 following exposure to IL-1, and displayed a remarkable sensitivity for IL-1 (Akoum et al 1995(Akoum et al , 1996(Akoum et al , 2002. In keeping with our findings, data from Lebovic et al (2000) suggest that the ability of IL-1b to activate an angiogenic phenotype in endometriotic stromal cells, but not in stromal cells from normal endometrium, is mediated by the functional signaling receptor IL-1RI.…”

Section: Introductionmentioning

confidence: 95%

“…Interleukin-1, a principal macrophage-derived and major proinflammatory cytokine, may play a central role in the integrated inflammatory cascade associated with endometriosis and in propagating endometriotic implants through a proinflammatory stimulus, synthesis of chemokines, growth, and angiogenic factors (Akoum et al 1995, Lebovic et al 2001b. Increased concentrations of the cytokine were found in the peritoneal fluid of women with endometriosis (Fakih et al 1987, Mori et al 1992, Taketani et al 1992 as well as in ectopic endometrial implants (Bergqvist et al 2001).…”

Section: Introductionmentioning

confidence: 99%

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Increased expression of interleukin-1 receptor type 1 in active endometriotic lesions

Lawson

Al-Akoum

Maheux³

et al. 2007

Reproduction

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The establishment and progression of ectopic endometrial implants are dependent upon their interaction with and responsiveness to the stimuli present in their new environment. According to our and other previous studies, immune cells-derived cytokines, such as IL-1, may alone or in concert with estrogens, enhance the capability of ectopic endometrial cells to implant and develop into the host tissue. In the present study, immunohistochemical and dual immunofluorescence analyses showed that the functional signaling interleukin-1 receptor type 1 (IL-1RI) is expressed in endometriotic tissue, particularly in the glands, and identified endothelial cells, macrophages, and T-lymphocytes as cells having marked expression of IL-1RI. The highest concentrations of IL-1RI protein in endometriotic tissue, as evaluated using histological score (HSCORE) and measured by ELISA, were found in red endometriotic lesions as compared with typical black-blue or white lesions. Western blotting showed a significant increase in the levels of the 50 kDa band, whose apparent molecular weight corresponds to the soluble form of IL-1RI. RT-PCR analysis of IL-1 mRNA levels showed a pattern of expression comparable to that of the protein. Interestingly, IL-1RI expression was more significant in the proliferative than in the secretory phase of the menstrual cycle. Marked expression of IL-1RI, the functional signaling receptor that mediates cell activation by IL-1, in red endometriotic implants, which are highly vascularized and represent the earliest and most active forms of the disease, point to a higher cell receptivity for IL-1 in these lesions, a relationship with the activity of the disease and a possible involvement in the early steps of endometriotic tissue growth and development. Reproduction (2007) 133 265-274

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Section: Discussionsupporting

confidence: 68%

Section: Il-1ri Expression In Ectopic Endometrial Tissuesupporting

confidence: 72%

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Increased expression of interleukin-1 receptor type 1 in active endometriotic lesions

Lawson

Al-Akoum

Maheux³

et al. 2007

Reproduction

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show abstract

“…In the peritoneal fluid in particular, the number of activated macrophages increases 4 and the chemotactic activity of immune system cells is higher compared to controls. [5][6][7][8] The levels of cytokines, 9 -14 growth factors, [15][16][17] and prostaglandins 18 -20 are elevated whereas angiogenic activity in vivo is increased in patients with endometriosis in comparison to females without the disease. [21][22][23] It still remains an open question as to what extent the peritoneal environment influences the establishment and/or progression of endometriosis .…”

mentioning

confidence: 99%