Cytokine Gene Polymorphisms in Kidney Transplantation

Dhaouadi, Tarak; Sfar, Imen; Bardi, R.; Jendoubi-Ayed, S.; Abdallah, T. Ben; Ayed, K.; Gorgi, Yousr

doi:10.1016/j.transproceed.2012.12.006

Cited by 28 publications

(31 citation statements)

References 31 publications

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“…Among the 14 eligible studies, 9 were renal transplantation[18]–[26], 3 were liver transplantation [9], [27], [28], and 2 were heart transplantation[13], [29]. As for ethnicity, 7 were studies of Caucasians [9], [22], [23], [27], [28], [37], 3 studies were of Asians [19]–[21], and 4 studies of mixed ethnicity [13], [18], [26], [29].…”

Section: Resultsmentioning

confidence: 99%

“…These two SNPs together result in nine potential inherited haplotypes, which could be categorized into three groups according to the in vitro production levels: high producer (HP) (T/T G/G and T/C G/G), intermediate producer (IP) (T/C G/C, T/T G/C, and C/C G/G) and low producer (LP) (C/C G/C, C/C C/C, T/T C/C and T/C C/C) [16], [17]. Since the first study conducted by Pelletier et al to evaluate the haplotypic association of TGFB1 +869 T/C and +915 G/C polymorphisms with AR risk in kidney transplant recipients [18], numerous molecular epidemiological studies have been conducted in different solid organ transplants, including kidney transplants [19]–[26], liver transplants [9], [27], [28], and heart transplants [13], [29]. However, the results of these studies were inconclusive.…”

Section: Introductionmentioning

confidence: 99%

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Combined Effects of TGFB1 +869 T/C and +915 G/C Polymorphisms on Acute Rejection Risk in Solid Organ Transplant Recipients: A Systematic Review and Meta-Analysis

et al. 2014

PLoS ONE

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BackgroundTransforming growth factor-beta 1(TGF-β1) is involved in the development of acute rejection (AR) episodes in solid organ transplant recipients; and a number of studies have been conducted to investigate the combined effects of human TGF-β1 gene (TGFB1) +869 T/C and +915 G/C polymorphisms on AR risk. However, the results obtained are inconclusive.MethodsEligible studies that investigated the haplotypic association between TGFB1 +869 T/C and +915 G/C polymorphisms and AR risk were comprehensively searched in the PUBMED, EMBASE, China National Knowledge Infrastructure, and Wanfang Database. Statistical analyses were performed by using STATA 12.0 and Review Manager 5.0.ResultsFourteen eligible studies with 565 AR cases and 1219 non-AR cases were included. Overall, a significantly decreased risk was detected in patients carried with intermediate producer (IP) haplotypes (T/C G/C, T/T G/C, and C/C G/G) and/or low producer (LP) haplotypes (C/C G/C, C/C C/C, T/T C/C, and T/C C/C) compared with high producer (HP) haplotypes (T/T G/G and T/C G/G; IP vs. HP: OR = 0.75, 95% CI, 0.58–0.96, P heterogeneity = 0.238; IP/LP vs. HP: OR = 0.77, 95% CI, 0.61–0.98, P heterogeneity = 0.144). In addition, subgroup analysis by transplant types demonstrated a similar association in patients receiving heart transplant (IP vs. HP: OR = 0.32, 95% CI, 0.14–0.73, P heterogeneity = 0.790; IP/LP vs. HP: OR = 0.41, 95% CI, 0.20–0.85, P heterogeneity = 0.320).ConclusionsThe current meta-analysis and systematic review indicated that recipient TGFB1 HP haplotypes were significantly associated with an increased risk for AR in solid organ transplant recipients, particularly patients receiving cardiac allograft.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Combined Effects of TGFB1 +869 T/C and +915 G/C Polymorphisms on Acute Rejection Risk in Solid Organ Transplant Recipients: A Systematic Review and Meta-Analysis

et al. 2014

PLoS ONE

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“…The exception is TNFA rs1800629 (−308). Associations have been found between this SNP and numerous outcomes in donors and recipients: acute rejection, recipients [21,44,46,[58][59][60][61][62][63]; graft survival, recipients [27,64]; graft survival, donors [65]; associations in sub group analyses, recipients [66][67][68], associations in sub group analyses, donors [49]; associations with other phenotypes/multiple phenotypes [69][70][71][72]; donors: [73] (see Table 2). …”

Section: Notable Associations: Tnfa Rs1800629 (−308)mentioning

confidence: 99%

Genetic polymorphisms in the immune response: A focus on kidney transplantation

Stojanova

Pouché

Picard

2016

Clinical Biochemistry

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“…TNF gene polymorphism at position G/A-308 in donors with high levels of TNF production is associated with a higher risk of rejection, delayed graft function/survival in kidney transplant recipients [49, 50]. However, some reports fail to show an association [51] and conflicting data exist as to whether serum/urine TNF levels reflect reliably the rejection crisis [52].…”

Section: Tnfr2 and Acrmentioning

confidence: 99%

Tumor Necrosis Factor Receptor 2: Its Contribution to Acute Cellular Rejection and Clear Cell Renal Carcinoma

Wang

Al‐Lamki

2013

BioMed Research International

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Tumor necrosis factor receptor 2 (TNFR2) is a type I transmembrane glycoprotein and one of the two receptors that orchestrate the complex biological functions of tumor necrosis factor (TNF, also designed TNF-α). Accumulating experimental evidence suggests that TNFR2 plays an important role in renal disorders associated with acute cellular rejection and clear cell renal carcinoma but its exact role in these settings is still not completely understood. This papers reviews the factors that may mediate TNFR2 induction in acute cellular rejection and clear cell renal carcinoma and its contribution to these conditions and discusses its therapeutic implications. A greater understanding of the function of TNFR2 may lead to the development of new anti-TNF drugs.

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Cytokine Gene Polymorphisms in Kidney Transplantation

Cited by 28 publications

References 31 publications

Combined Effects of TGFB1 +869 T/C and +915 G/C Polymorphisms on Acute Rejection Risk in Solid Organ Transplant Recipients: A Systematic Review and Meta-Analysis

Combined Effects of TGFB1 +869 T/C and +915 G/C Polymorphisms on Acute Rejection Risk in Solid Organ Transplant Recipients: A Systematic Review and Meta-Analysis

Genetic polymorphisms in the immune response: A focus on kidney transplantation

Tumor Necrosis Factor Receptor 2: Its Contribution to Acute Cellular Rejection and Clear Cell Renal Carcinoma

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