Combined Effects of TGFB1 +869 T/C and +915 G/C Polymorphisms on Acute Rejection Risk in Solid Organ Transplant Recipients: A Systematic Review and Meta-Analysis

Abstract

BackgroundTransforming growth factor-beta 1(TGF-β1) is involved in the development of acute rejection (AR) episodes in solid organ transplant recipients; and a number of studies have been conducted to investigate the combined effects of human TGF-β1 gene (TGFB1) +869 T/C and +915 G/C polymorphisms on AR risk. However, the results obtained are inconclusive.MethodsEligible studies that investigated the haplotypic association between TGFB1 +869 T/C and +915 G/C polymorphisms and AR risk were comprehensively searched in the PUBMED, EMBASE, China National Knowledge Infrastructure, and Wanfang Database. Statistical analyses were performed by using STATA 12.0 and Review Manager 5.0.ResultsFourteen eligible studies with 565 AR cases and 1219 non-AR cases were included. Overall, a significantly decreased risk was detected in patients carried with intermediate producer (IP) haplotypes (T/C G/C, T/T G/C, and C/C G/G) and/or low producer (LP) haplotypes (C/C G/C, C/C C/C, T/T C/C, and T/C C/C) compared with high producer (HP) haplotypes (T/T G/G and T/C G/G; IP vs. HP: OR = 0.75, 95% CI, 0.58–0.96, P heterogeneity = 0.238; IP/LP vs. HP: OR = 0.77, 95% CI, 0.61–0.98, P heterogeneity = 0.144). In addition, subgroup analysis by transplant types demonstrated a similar association in patients receiving heart transplant (IP vs. HP: OR = 0.32, 95% CI, 0.14–0.73, P heterogeneity = 0.790; IP/LP vs. HP: OR = 0.41, 95% CI, 0.20–0.85, P heterogeneity = 0.320).ConclusionsThe current meta-analysis and systematic review indicated that recipient TGFB1 HP haplotypes were significantly associated with an increased risk for AR in solid organ transplant recipients, particularly patients receiving cardiac allograft.

Blood Groups Distribution and Gene Diversity of the ABO and Rh (D)Lociin the Mexican Population

“…In transplant medicine, several works have studied the effects of genetic variants of a wide range of proteins including Human Leukocyte Antigens (HLA) in the risk of rejection in allograft transplants [ 15 – 17 , 53 , 54 ]. For example, in Mexico, some works have found a positive association between specific HLA haplotypes and acute kidney rejection [ 15 , 17 ].…”

Genetic polymorphisms in the immune response: A focus on kidney transplantation

“…Ge and colleagues performed a meta-analysis of studies involving TGFB1 c10 (rs1800470) and c25 (rs1800471) loci and acute rejection [57]. Among kidney transplant recipients (9 studies, 123 cases, 301 controls) there was no association for purported intermediate versus high production phenotypes.…”

Molecular Characterization of the Oncogenic Potential and Mechanisms of Cytomegalovirus Infecting MRC-5 Cells

“…Therefore, HCMV might acts like a K-ras oncogene in inducing transformation. Another upregulated gene involved in MAPK pathway was TGFB1, which also triggers local immune suppression (31) and induces cancer (32) . Enhanced expression of TGFB1 was found to enhance several cancer-related events such as cell division, cell motility, and the development of new blood vessels, angiogenesis.…”