Cytokine gene polymorphisms and susceptibility to cutaneous leishmaniasis in Iranian patients

Kamali-Sarvestani, Eskandar; Rasouli, Manoochehr; Mortazavi, Seyedeh Hamideh; Gharesi‐Fard, Behrouz

doi:10.1016/j.cyto.2006.07.016

Cited by 42 publications

(36 citation statements)

References 51 publications

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“…Genetics of the host could provide critical information for the discovery of key steps in the pathogenesis of leishmania infections. 23 The present study delineate that Giemsa stain has a detection rate of 70.6% in clinically diagnosed cases. This result is near to that obtained by in which the rates were 73% and 69.5% respectively.…”

Section: Al-khayat Zay Et Al Int J Res Dermatol 2018 Mar;4(1):1-7mentioning

confidence: 99%

“…Their presence and their cytotoxic activity are directly correlated to the lesion size. 19,22,23 Studies in populations living in endemic areas suggest that some gene loci seem specific to particular clinical manifestations. Genetics of the host could provide critical information for the discovery of key steps in the pathogenesis of leishmania infections.…”

Section: Al-khayat Zay Et Al Int J Res Dermatol 2018 Mar;4(1):1-7mentioning

confidence: 99%

“…This occlusion may explain the disappearance of the amastigotes at certain stages of the disease. [23][24][25] Hepburn clarified that over the next months of the disease process, there is a gradual decrease in the number of amastigotes and macrophages, which consequently will lead to the formation of granulomatous infiltrate consisting of lymphocytes, epithelioid cells and multinucleate giant cells. 25 Therefore Giemsa stain will be negative.…”

Section: Al-khayat Zay Et Al Int J Res Dermatol 2018 Mar;4(1):1-7mentioning

confidence: 99%

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A clinico-epidemiological study on cutaneous leishmaniasis in Erbil, Iraq (2015-2017)

Al-khayat

Agha²,

Alharmni

et al. 2018

Int J Res Dermatol

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Background: The objective of the study was to determine the incidence of cutaneous leishmaniasis (CL) in Makhmur District (Erbil Province).Methods: A cross-sectional, observational, descriptive study was performed in the outpatient clinic of Makhmur General Health Center. All the patients who presented at the dermatology clinic during the period from January 2015 to January 2017 were included in the study. The provisional diagnosis was dependent mainly on clinical examination in addition to Giemsa stain.Results: A total of 1264 cutaneous leishmaniasis cases were diagnosed during the study period with males representing 54.6% of the cases. The study participants ranged from 10 months to 61 years. Age group <15 years were 53.5%. Clinically, 49.3% of patients had one lesion, 51.5% of patients had wet type. Most lesions were found on both limbs (48.8%). The highest number of cases was recorded during February (29.1%) and November (21.8%), while the lowest rate of cases was recorded in July (0.2%). According to stain results, 70.6% of the cases were positive to giemsa stain.Conclusions: CL is endemic in Makhmur district. Males were infected in higher percent than females and this may be due to cultural, occupational and social factors.

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Section: Al-khayat Zay Et Al Int J Res Dermatol 2018 Mar;4(1):1-7mentioning

confidence: 99%

Section: Al-khayat Zay Et Al Int J Res Dermatol 2018 Mar;4(1):1-7mentioning

confidence: 99%

Section: Al-khayat Zay Et Al Int J Res Dermatol 2018 Mar;4(1):1-7mentioning

confidence: 99%

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A clinico-epidemiological study on cutaneous leishmaniasis in Erbil, Iraq (2015-2017)

Al-khayat

Agha²,

Alharmni

et al. 2018

Int J Res Dermatol

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“…In a study conducted by Kamali-Sarvestani et al, IL-12 A allele, which is associated with higher production of IL-12, was significantly more frequent in the controls than the patients. Moreover, AA genotype was significantly more frequent in the controls than the patients (24). Based on these results, it can be concluded that individuals who acquire the AA genotype may produce higher levels of IL-12 which can lead to the initiation of CMI response to brucellosis.…”

Section: Discussionmentioning

confidence: 76%

Association Between Cytokine Gene Polymorphisms and Human Susceptibility to Brucellosis

Kabiri

Rajabnia

Pournajaf

et al. 2017

Arch Pediatr Infect Dis

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Background: Allelic single nucleotide polymorphisms (SNPs) in cytokine-encoding genes can affect the degree of cytokine production, and may be related to the tendency to infectious illnesses as well as various clinical consequences. Objectives: The aim of this work was to evaluate the possible role of SNPs in the regions of the IL-10 (-592), , , IL-12 (+1188), IFN-γ (+874), TNF-α (-308), and TNF-β (+252) genes in susceptibility or resistance to brucellosis and its crucial complications. Methods: In a period of one year, 125 patients with acute brucellosis referring to 3 large public teaching hospitals were enrolled in this study. We studied the SNPs of IL-10, IL-15, IL-18, IL-12, IFN-γ, and TNF-α/β genes using the allele specific polymerase chain reaction (AS-PCR) with sequence-specific primers. Results: Frequency of GG genotype in the TNF-α and TNF-β-encoding genes increased significantly by 52% and 31.2% in patient and control groups, respectively. For IFN-γ, TA genotype was found highly enhanced in patients (60%), while the frequency of AA and TT genotypes were higher in controls (23.2% and 26.4%, respectively). The AA and CC SNPs in IL-12 were dominant in both patient (78.4%) and control (14.4%) groups. In the patient group, the GG and TT genotypes had a higher frequency for genes encoding IL-15 (33.6%) and IL-18 (89.6%). Conclusions: Based on the present study, some SNPs within the several cytokine genes, including TNF-α/β (-308/+252), IFN-γ (+874), IL-15 (-367), , and IL-12 (+1188) are related to the susceptibility or resistance to brucellosis. In order to approve the biological consequence of our results, additional investigations should be carried out in larger population groups.

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“…In Mexico PCR-based genotyping confirmed earlier serological studies demonstrating significant disease association with several class II human leucocyte antigen (HLA) genes [88] . A recent study investigating cytokine gene polymorphisms in an Iranian population with CL identified that genetic variation of the IL-4 promoter region was associated with disease susceptibility whereas the IFN-γ gene appeared to influence disease progression to a chronic variant [89] . Identification of genes for both disease susceptibility as well as progression provides potential therapeutic targets and prognostic indicators.…”

Section: Genetic Susceptibility and Pharmacogenetic Potentialmentioning

confidence: 99%

Cutaneous leishmaniasis: therapeutic strategies and future directions

Ameen

2007

Expert Opinion on Pharmacotherapy

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Cutaneous leishmaniasis is a major tropical infection caused by vector-borne protozoa of the Leishmania species. Disease presentation, clinical course, prognosis and response to therapy is species- and geographic region-dependent. A wide variety of treatment modalities exist for the diverse spectrum of clinical disease. Traditional antileishmanial systemic agents such as antimonials, pentamidine and amphotericin are limited by toxic side effects, parenteral route of administration and emerging drug resistance. Newer agents such as oral miltefosine have shown efficacy and tolerability. However, use of systemic pharmacotherapies remains limited by their relative high cost in developing countries and despite advances in basic scientific research, there has been little progress in new drug development for what remains a neglected disease afflicting 12 million of the world's poorest population. This article examines the merits of existing and emerging therapies and reasons for variation in therapy response.

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Cytokine gene polymorphisms and susceptibility to cutaneous leishmaniasis in Iranian patients

Cited by 42 publications

References 51 publications

A clinico-epidemiological study on cutaneous leishmaniasis in Erbil, Iraq (2015-2017)

A clinico-epidemiological study on cutaneous leishmaniasis in Erbil, Iraq (2015-2017)

Association Between Cytokine Gene Polymorphisms and Human Susceptibility to Brucellosis

Cutaneous leishmaniasis: therapeutic strategies and future directions

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