Cytokine gene expression following RSV-A infection

Khare, Vishwa M.; Saxena, V.K.; Tomar, Alka; Nyinawabera, Angelique; Singh, Kunal; Ashby, Charles R.; Tiwari, Anjali

doi:10.2741/4729

Cited by 5 publications

(3 citation statements)

References 6 publications

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“…(1) Proteins are represented in different forms such as receptors, enzymes, ion channels, transporters, regulatory proteins (Alexander et al, 2019a;Alexander et al, 2019b;Alexander et al, 2019c;Alexander et al, 2019d;Alexander et al, 2019e;Alexander et al, 2019f;Alexander et al, 2019g), cytokines, chemokines (Khare et al, 2019), structural proteins, cytoskeletal proteins, microtubules forming the mitotic spindle, transcription factors, and hormones. MHC-B complex genes that encode for cell surface proteins, are activated and affect the tumor outcome (Khare et al, 2018).…”

Section: Major Cellular Targets For Secondary Metabolitesmentioning

confidence: 99%

Multiple Molecular Mechanisms to Overcome Multidrug Resistance in Cancer by Natural Secondary Metabolites

et al. 2021

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Plant secondary metabolites (SMs) common natural occurrences and the significantly lower toxicities of many SM have led to the approaching development and use of these compounds as effective pharmaceutical agents; especially in cancer therapy. A combination of two or three of plant secondary metabolites together or of one SM with specific anticancer drugs, may synergistically decrease the doses needed, widen the chemotherapeutic window, mediate more effective cell growth inhibition, and avoid the side effects of high drug concentrations. In mixtures they can exert additive or even synergistic activities. Many SM can effectively increase the sensitivity of cancer cells to chemotherapy. In phytotherapy, secondary metabolites (SM) of medicinal plants can interact with single or multiple targets. The multi-molecular mechanisms of plant secondary metabolites to overcome multidrug resistance (MDR) are highlighted in this review. These mechanisms include interaction with membrane proteins such as P-glycoprotein (P-gp/MDR1); an ATP-binding cassette (ABC) transporter, nucleic acids (DNA, RNA), and induction of apoptosis. P-gp plays an important role in the development of MDR in cancer cells and is involved in potential chemotherapy failure. Therefore, the ingestion of dietary supplements, food or beverages containing secondary metabolites e.g., polyphenols or terpenoids may alter the bioavailability, therapeutic efficacy and safety of the drugs that are P-gp substrates.

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Section: Major Cellular Targets For Secondary Metabolitesmentioning

confidence: 99%

Multiple Molecular Mechanisms to Overcome Multidrug Resistance in Cancer by Natural Secondary Metabolites

et al. 2021

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“…Rous sarcoma virus (RSV) infection of susceptible chickens is followed by increased expression of pro-inflammatory cytokines such as in spleen including interleukin (IL) 8 and IL 10. Moreover, there is marked expression of the Th1 cytokines IFN-γ and TNF-α in the spleen ( Khare et al, 2019 ). In pigeons, infection with Newcastle disease viruses increases expression of RIG-I , IL-6, IL-1 β, CCL5 , and IL-8 genes in the spleen ( Xiang et al, 2019 ).…”

Section: Immune Systemmentioning

confidence: 99%

Avian Physiology: Are Birds Simply Feathered Mammals?

Scanes

2020

Front. Physiol.

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“…Anti-cancer therapy involves many novel therapeutic interventions, such as modification of tumor microenvironment, innate immune gene response, the induction of apoptotic and/or autophagic cell death in premalignant and malignant cells ( Yao et al., 2017 ; Yoshino et al., 2018 ; Khare et al., 2019 ). Additionally, the role of necrotic cell death in chemotherapeutic treatment has been increasing appreciated since tumor cells evolve diverse strategies to evade apoptosis during tumor development ( Cui et al., 2011 ; Xu et al., 2014 ).…”

Section: Introductionmentioning

confidence: 99%

JNK and Autophagy Independently Contributed to Cytotoxicity of Arsenite combined With Tetrandrine via Modulating Cell Cycle Progression in Human Breast Cancer Cells

Yuan

et al. 2020

Front. Pharmacol.

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Novel therapeutic strategies for breast cancer are urgently needed due to the sustained development of drug resistance and tumor recurrence. Trivalent arsenic derivative (arsenite, As III) has been reported to induce cytotoxicity in breast cancer cells. We recently demonstrated that As III plus tetrandrine (Tetra), a Chinese plant-derived alkaloid, exerted potent antitumor activity against human breast cancer cells, however, the underlying mechanisms for their action have not been well defined. In order to provide fundamental insights for understanding the action of As III plus Tetra, the effects of the combined regimen on two breast cancer cell lines T47D and MDA-MB-231 were evaluated. Compared to T47D cells, MDA-MB-231 cells were much more susceptible to the synergistic cytotoxic effects of As III and Tetra. Besides the induction of apoptotic/ necrotic cell death, S-phase arrest and autophagic cell death were also observed in MDA-MB-231 cells. Exposure of MDA-MB-231 cells to As III and Tetra caused the activation of MAPKs. Cytotoxicity of the combined regimen in MDA-MB-231 cell was significantly abrogated by SP600125, a potent c-Jun N-terminal kinase (JNK) inhibitor. However, similar abrogation was not caused by p38 and ERK inhibitors. The addition of either autophagy inhibitors (3-methyladenine or wortmannin) or SP600125 corrected the combined regimen-triggered S-phase arrest, whereas had little effect on the apoptosis/ necrosis induction in the cells. Surprisingly, SP600125NC, a negative control for SP600125, significantly strengthened S-phase arrest and the cytotoxicity induced by

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Cytokine gene expression following RSV-A infection

Cited by 5 publications

References 6 publications

Multiple Molecular Mechanisms to Overcome Multidrug Resistance in Cancer by Natural Secondary Metabolites

Multiple Molecular Mechanisms to Overcome Multidrug Resistance in Cancer by Natural Secondary Metabolites

Avian Physiology: Are Birds Simply Feathered Mammals?

JNK and Autophagy Independently Contributed to Cytotoxicity of Arsenite combined With Tetrandrine via Modulating Cell Cycle Progression in Human Breast Cancer Cells

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