Cytokeratin expression in lichen amyloidosus and macular amyloidosis

Apaydın, Rebiay; Gürbüz, Yeşim; Bayramgürler, Dilek; Müezzínoğlu, Bahar; Bilen, Nilgün

doi:10.1111/j.1468-3083.2004.00905.x

Cited by 33 publications

(28 citation statements)

References 26 publications

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“…Interestingly, although CKs coexpressed in pairs consisting of one basic and one acidic CK, we detected predominantly basic CKs in STA. We also found similar results in lichen amyloidosis and macular amyloidosis [26]. Chang et al reported that amyloid deposits of 30 biopsy specimens of BCC were reactive with CK 5 antibody, but not with CK 14 [16].…”

Section: Discussionsupporting

confidence: 83%

Cytokeratin contents of basal cell carcinoma, epidermis overlying tumour, and associated stromal amyloidosis: An immunohistochemical study

Apaydın

Gürbüz

Bayramgürler

et al. 2005

Amyloid

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Cytokeratins (CKs) are expressed specifically in the cytoplasm of epithelial cells. We investigated the expression of CKs immunohistochemically in basal cell carcinomas (BCCs), epidermis overlying tumour, and skin tumor-associated amyloidosis (STA). Twenty cases of BCC, 11 of which had STA were included to the study. The primary antibodies of CK1-8 (AE3), CK10 (DEK-10), CK14 (LL002), CK17 (E3), CK18 (DC10), CK19 (KS19.1), CK 5/6/18 (LP34), CK8/18 (5D3) were applied to the section immunohistochemically. In BCCs without STA, CK1-8, CK14 and CK17 antibodies were expressed by tumour tissue in all biopsy specimens. In the BCCs with STA, tumour tissue was immunoreactive always with CK1-8 and CK17 antibodies, and commonly immunoreactive with anti-CK 14 antibody. In the epidermis overlying tumour tissue, there was positive immunoreactivity with anti-CK 1-8, CK 5/6/18, CK 10 and CK 14 antibodies in all biopsy specimens. Anti-CK 17 antibody was also positive in 17 biopsy specimens. STA is immunoreactive with anti-CK1-8 in all specimens. There was mild staining with anti-CK5/6/18 and with anti-CK19 whereas no immunoreactivity with anti-CK10 and CK18 antibodies was found. In conclusion, we could not find a significant CK expression difference between BCCs with and without STA. Weak positivity and a few number of CKs were shown in STA when compared with those of BCC and epidermis overlying tumour tissue expressing the more variable CKs. Interestingly, although CKs coexpressed in pairs consisting of one basic and one acidic CK, we detected predominantly basic CKs in STA.

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Section: Discussionsupporting

confidence: 83%

Cytokeratin contents of basal cell carcinoma, epidermis overlying tumour, and associated stromal amyloidosis: An immunohistochemical study

Apaydın

Gürbüz

Bayramgürler

et al. 2005

Amyloid

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“…38,41,68,153 It has been demonstrated that the amyloid deposits are mainly made of CK5. 68,152,155 Among this group, 2 forms are distinguished as a primary type and a secondary type. The secondary type is, as the name implies, secondary to a lesion or condition.…”

Section: Keratinic Amyloidosismentioning

confidence: 99%

Cutaneous Amyloidosis: A Concept Review

Fernández-Flores

2012

The American Journal of Dermatopathology

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Concepts and semantics are crucial for good communication between clinicians and pathologists. Amyloidosis was described more than 150 years ago. Therefore, the terminology related to it is abundant, varied, and sometimes complex. In this report, we intend to discuss several terms related to the disease, with special emphasis on cutaneous amyloidosis. We present a review, from Virchow to present, of the concepts related to amyloidosis: its nature, the classification of cutaneous forms of the disease, and the techniques used in its diagnosis.

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“…The dermal amyloid material is thought to be derived from keratin peptides and other proteins such as apolipoprotein E2. Immunohistochemically, reaction of amyloid deposits with antihuman keratin antibodies such as CK 5/6/18 and MNF 116 also supports this hypothesis [6]. …”

Section: Answer and Explanationmentioning

confidence: 89%