Cytokeratin alteration in oral leukoplakia and oral squamous cell carcinoma

Fillies, Thomas; Jogschies, Mirco; Kleinheinz, Johannes; Brandt, Burkhard; Joos, Ulrich; Buerger, Horst

doi:10.3892/or.18.3.639

Cited by 40 publications

(64 citation statements)

References 20 publications

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“…DAPI was used for nuclear staining. expressed in majority of the carcinomas (Moll et al, 2008), including OSCC (Vaidya et al, 1996), and their expression has been correlated with aggressiveness of the tumour and poor prognosis (Fillies et al, 2007). Aberrant expression of this keratin pair at the invasive front of OSCC has also been correlated with invasion of these tumours (Schaafsma et al, 1993).…”

Section: Discussionmentioning

confidence: 99%

Loss of keratins 8 and 18 leads to alterations in α6β4-integrin-mediated signalling and decreased neoplastic progression in an oral-tumour-derived cell line

Alam

Kundu

Dalal

et al. 2011

Journal of Cell Science

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Keratins 8 and 18 (K8 and K18) are predominantly expressed in simple epithelial tissues and perform both mechanical and regulatory functions. Aberrant expression of K8 and K18 is associated with neoplastic progression and invasion in squamous cell carcinomas (SCCs). To understand the molecular basis by which K8 promotes neoplastic progression in oral SCC (OSCC), K8 expression was inhibited in AW13516 cells. The K8-knockdown clones showed a significant reduction in tumorigenic potential, which was accompanied by a reduction in cell motility, cell invasion, decreased fascin levels, alterations in the organization of the actin cytoskeleton and changes in cell shape. Furthermore, K8 knockdown led to a decrease in α6β4 integrin levels and α6β4-integrin-dependent signalling events, which have been reported to play an important role in neoplastic progression in epithelial tissues. Therefore, modulation of α6β4 integrin signalling might be one of the mechanisms by which K8 and K18 promote malignant transformation and/or progression in OSCCs.

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Section: Discussionmentioning

confidence: 99%

Loss of keratins 8 and 18 leads to alterations in α6β4-integrin-mediated signalling and decreased neoplastic progression in an oral-tumour-derived cell line

Alam

Kundu

Dalal

et al. 2011

Journal of Cell Science

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“…Interestingly, differential expression pattern of CK14 was observed in oral squamous cell carcinoma [17][18][19]. During the differentiation of mouse embryonic stem cells into keratinocytes, CK14 appears first and after stratification it remains in the basal layer, where highly proliferative cells are known to reside [20].…”

Section: Introductionmentioning

confidence: 99%

Aberrant expression of β-catenin and its association with ΔNp63, Notch-1, and clinicopathological factors in oral squamous cell carcinoma

Gokulan

Devaraj

2011

Clin Oral Invest

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The present study focuses on the correlation between the expression pattern of β-catenin (component of Wnt signaling), ΔNp63 (proliferation marker), and Notch 1 (transmembrane receptor) in oral squamous cell carcinoma. The study also aims to investigate the interaction between β-catenin and ΔNp63 in oral cancer. Furthermore, we also analyzed the prognostic significance of β-catenin, ΔNp63, and Notch 1 in oral squamous cell carcinoma. Immunohistochemical analysis of β-catenin, ΔNp63, and Notch 1 were done in 62 cases of oral squamous cell carcinoma. Co-immunoprecipitation analysis was done to study the possible interaction between β-catenin and ΔNp63 in oral cancer. Kaplan-Meier method was used to estimate overall and disease-free survival, and the Log-rank test was used to compare the resulting curves. Statistically significant positive correlation was found between the localization of β-catenin and the expression of ΔNp63 (p = 0.001**, r (s) = 0.427), whereas, no significant association was found between the expression pattern of β-catenin and Notch 1. Interestingly, interaction between β-catenin and ΔNp63 was observed in oral carcinoma. Moreover, β-catenin and ΔNp63 may be related to worst survival in oral carcinoma. Statistically significant positive association between localization of β-catenin and expression of ΔNp63 suggests that they might have dependent roles in maintaining the proliferation of oral carcinoma cells. In addition, the downregulated expression of Notch 1 was related to invasion and differentiation status of oral carcinoma cells. Furthermore, β-catenin and ΔNp63 may be used as independent prognostic markers of oral carcinoma. On the other hand, interaction of β-catenin with ΔNp63 may be a key event in maintaining the proliferation of oral carcinoma cells. The present study indicates that β-catenin and ΔNp63 may be used as independent prognostic markers of oral carcinoma and the interaction of β-catenin with ΔNp63 may be a crucial event in regulating proliferation and differentiation of oral carcinoma cells, which may be used as a target for therapeutic implications.

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“…However, the hypothesis that numerous immunohistochemical analyses are useful in the diagnosis of papillary-type cutaneous VC was confuted by the current study. CK13, 8 and 18 are reported to be useful markers in the diagnosis of squamous cell carcinoma in the head and neck region (13,15), and CK8 and 18 appear to be associated with the invasion and metastasis of squamous cell carcinoma (16). However, these CKs stained negatively in the neoplastic and surrounding healthy epidermal tissue of the present lesion, and, therefore, were not useful in the differential diagnosis of the present case.…”

Section: Discussionmentioning

confidence: 58%

“…CK10 has previously been described as a valuable tool in the diagnosis of oral squamous cell carcinoma and clonal seborrheic keratosis (13,14). Therefore, immunostaining for CK10 may aid in the diagnosis of cutaneous VC.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical findings and differential diagnosis of papillary-type cutaneous verrucous carcinoma of the neck: A case report

et al. 2015

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Abstract. Verrucous carcinoma (VC) is a rare subtype of squamous cell carcinoma, with the majority of cases occurring in the oral cavity and genital area. The present study describes a rare case of cutaneous VC of the neck manifesting as a semi-pedunculated multinodular protrusion. Histological analysis revealed thickening of the epidermis and papillary growth. Although cellular atypia was generally mild, a large number of mitoses were observed, of which a small number were abnormal. Additionally, bulbous subepidermal invasion was observed. The lesion was differentiated from papillary squamous cell carcinoma, another rare subtype of squamous cell carcinoma, based on the presence of epidermal verrucous growth and the lack of remarkable nuclear atypia. Benign disorders, including seborrheic keratosis, fibroepithelial polyp, verruca vulgaris and pseudocarcinomatous hyperplasia, were also differentiated from the lesion. Immunohistochemical analysis of cytokeratin (CK)10 expression revealed attenuated staining of the lesion, therefore, anti-CK10 immunohistochemistry may be valuable in the diagnosis of VC.

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Cytokeratin alteration in oral leukoplakia and oral squamous cell carcinoma

Cited by 40 publications

References 20 publications

Loss of keratins 8 and 18 leads to alterations in α6β4-integrin-mediated signalling and decreased neoplastic progression in an oral-tumour-derived cell line

Loss of keratins 8 and 18 leads to alterations in α6β4-integrin-mediated signalling and decreased neoplastic progression in an oral-tumour-derived cell line

Aberrant expression of β-catenin and its association with ΔNp63, Notch-1, and clinicopathological factors in oral squamous cell carcinoma

Immunohistochemical findings and differential diagnosis of papillary-type cutaneous verrucous carcinoma of the neck: A case report

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