Immunohistochemical findings and differential diagnosis of papillary-type cutaneous verrucous carcinoma of the neck: A case report

Abstract

Abstract. Verrucous carcinoma (VC) is a rare subtype of squamous cell carcinoma, with the majority of cases occurring in the oral cavity and genital area. The present study describes a rare case of cutaneous VC of the neck manifesting as a semi-pedunculated multinodular protrusion. Histological analysis revealed thickening of the epidermis and papillary growth. Although cellular atypia was generally mild, a large number of mitoses were observed, of which a small number were abnormal. Additionally, bulbous subepidermal invasion was observed. The lesion was differentiated from papillary squamous cell carcinoma, another rare subtype of squamous cell carcinoma, based on the presence of epidermal verrucous growth and the lack of remarkable nuclear atypia. Benign disorders, including seborrheic keratosis, fibroepithelial polyp, verruca vulgaris and pseudocarcinomatous hyperplasia, were also differentiated from the lesion. Immunohistochemical analysis of cytokeratin (CK)10 expression revealed attenuated staining of the lesion, therefore, anti-CK10 immunohistochemistry may be valuable in the diagnosis of VC.

A Case of Huge Cutaneous Verrucous Carcinoma of the Neck

“…VC is a rare subtype of SCC [ 1 ] and generally arises from the mucosa rather than from the skin [ 2 ]. It typically originates from lesions of the oral cavity, genital area, or plantar surface, but rarely from a cervical skin lesion [ 4 ].…”

Squamous Cell Carcinoma Arising within Verruca Vulgaris on the Nipple

“…HPV is a group of approximately 100 strains of viruses that can cause disordered epithelial growth. This often results in the growth of warts on the hands, plantar surface of the feet, or anogenital region [ 15 ]. HPV strains are well-recognized contributors to SCC arising in anogenital, penile, cervical, and oropharyngeal areas of the body.…”