Cytohistopathological correlation of Papanicolaou smears: a hospital based study

Patil, Purwa; Jibhkate, Shubhangi Narayan

doi:10.18203/2320-1770.ijrcog20161424

Cited by 9 publications

(14 citation statements)

References 6 publications

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“…On Pap smears 2 cases and 4 cases were diagnosed as adenocarcinoma and squamous cell carcinoma respectively which showed 100% correlation on histopathology. In our study, the overall accuracy in our study was comparable to Atla et al 11 (83.33%), Patil et al 15 (82.1%) and Joshi et al 8 (80.0%) ( Table 4). This study shows a good correlation between Pap smear and cervical histology.…”

Section: Discussionsupporting

confidence: 88%

Correlation of Cervical Pap Smear with Histopathological Diagnosis in Cervical Lesions: A 2 Years Retrospective Study

Bindroo¹,

Garg²,

Gitika³

2019

IJCMR

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Introduction: Cervical cancer is one of the most common forms of cancer worldwide. In developing countries, cancer of uterine cervix is ranked second with a relative frequency of 15% of all cancers in women. Screening women with regular Pap smears allows diagnosis of treatable pre-invasive lesions. The objective of the study was to correlate the Pap smear diagnosis with histopathology and to know the accuracy of Pap smears, so as to assess the efficacy of Pap smears in diagnosing cervical lesions. Material and methods: This two year retrospective study was done in the department of Pathology in a tertiary care centre, which includes 250 Pap smears for which histopathological diagnosis was also done. Detailed clinical history of patients was taken from requisition forms received in cytology department along with Pap smears. The cervical biopsies or hysterectomies received from the same patients were also studied and then correlated with the diagnosis of Pap smears. Results: Out of 250 Pap smears, maximum patients (32%) belonged to the age group of 41-50 years and were multipara. Maximum cases were reported as NILM (59%),followed by ASCUS (16%), LSIL (15%), HSIL (7%), squamous cell carcinoma (1.6%) and 0.8% cases of adenocarcinoma were diagnosed. On histopathology, 41.2% cases were diagnosed as chronic cervicitis, 27.2% cases as chronic cervicitis with squamous metaplasia, CIN I (22.4%),CIN II (4.0%),CIN III (2.8%), squamous cell carcinoma (1.6%) and (0.8)% cases of adenocarcinoma. Overall sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy was 75.24%, 97.98%, 96.20%, 85.38% and 88.8%. Conclusion: As per our study, maximum number of cases diagnosed on Pap smears correlated on histopathology, thereby concluding that Pap smears have an important role in diagnosis of cervical lesions.

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Section: Discussionsupporting

confidence: 88%

Correlation of Cervical Pap Smear with Histopathological Diagnosis in Cervical Lesions: A 2 Years Retrospective Study

Bindroo¹,

Garg²,

Gitika³

2019

IJCMR

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“…8 The present study included 154 pap smear cases who also undergone biopsy or hysterectomy with most patients (35%) in the age group of 41-50 yrs and belong to para 2 (42%) followed by para 3 (25.6%). It has accordance with Sachan et al, 8 and Parija et al 9 The maximum number of patients presented with complaints of whitish discharge per vaginum (42%) and pain lower abdomen (35%) correlates with the study conducted by Bamanikar et al, 10 Atla et al, 11 and Bindroo et al 12 In our study out of 116 cases of NILM, 99% of cases correlated on histopathology which corroborated with the studies done by Atla et al, 11 and Bindroo et al 12 The incidence of Epithelial cell abnormality (ECA) was seen in 18.1% which correlated with Patil et al 13 But this incidence was higher than the study conducted by Malpani et al, 14 this may be because we had small sample size.…”

Section: Discussionsupporting

confidence: 90%

“…Though false negative rates are usually misjudged when using follow up controls, our value observation against immediate histologic 'gold-standard' reflects an effective screening program for cervical cancer. 13 In our study, the overall sensitivity, specificity, PPV, NPV and accuracy of pap smear was 90.57%, 62.50%, 95.41%, 43.47% and 87.66% respectively. These values were comparable to Bamanikar et al, 10 Atla et al, 11 and Malpani et al 14 (Table -3).…”

Section: Discussionsupporting

confidence: 52%

A two year retrospective study of cytohistopathological correlation of cervical smear in a tertiary care hospital

et al. 2021

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Background: Cervical cancer in women is the second most common cancer and the commonest cause of mortality in developing countries. The introduction of Pap smear test changed the scenario of cervical cancer with an intense drop in the incidence and mortality due to invasive cervical cancer. Aims and Objective: To evaluate the patterns of cervical smear cytology and to correlate the cervical smear diagnosis with histopathological diagnosis and to assess the efficacy of Pap smears in diagnosing cervical lesions. Materials and Methods: This two-year retrospective study (January 2018 to December 2019) was done in the department of Pathology in a tertiary care hospital. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy were calculated considering histopathological diagnosis of cervical biopsy as the gold standard. Results: A total of 316 Pap smears were studied, out of which we selected 154 cases who also undergone biopsy or hysterectomy. Epithelial cell abnormalities (ECA) were found in 28 cases (18.2%). Among this the most common ECA was Atypical squamous cells of undetermined significance (ASCUS) seen in 10 cases (6.5%) followed by LSIL (5.2%), HSIL (3.2%) and SCC of cervix (3.2%). The overall correlation between cervical cytology and histopathology was found in 125 out of 154 cases (81.16%). The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of pap smear was 90.57%, 62.50%, 95.41%, 43.47% and 87.66% respectively. Conclusion: Pap smear is a simple, safe, non-invasive and effective method for detection of lesions of the cervix and ECA. Hence, better awareness and periodical cytological screening programs can help in the early detection of malignant cervical lesions and thereby reducing the morbidity and mortality related to this malignancy.

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“…Evidences involving the performance of cytological abnormalities for predicting intraepithelial and invasive cervical neoplasias, whether squamous or glandular, were found with SE ranging from 30 to 100%, and SP from 86.8 to 99.3%. [16][17][18][19][20][21][22][23][24][25][26][27][28][29] This large divergence may be due to the diversity of cut-off points chosen to consider the tests as positive or negative, as well as to the use of different morphological criteria to interpret cytological smears and classify abnormal findings. Conversely, a study that used ASC-H þ as a cut-off point to ascertain the performance for the detection of CIN 2 þ reported SE of 67.9% and SP of 87%.…”

Section: Discussionmentioning

confidence: 99%

Performance of Conventional Cytology and Colposcopy for the Diagnosis of Cervical Squamous and Glandular Neoplasias

Fachetti-Machado

Alves

Moreira

2018

Rev Bras Ginecol Obstet

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Keywords► uterine cervical neoplasms ► cervical intraepithelial neoplasia ► squamous intraepithelial lesions of the cervix ► adenocarcinoma in situ ► papanicolaou test ► colposcopy ► sensitivity and specificity AbstractObjective To estimate the cytological and colposcopic performances for the diagnosis of cervical neoplasias.Methods Cross-sectional retrospective study with data from patients' charts. The participants underwent colposcopy, guided biopsies, and excision when needed. The cytological and colposcopic categorization followed the Bethesda System and the international colposcopic terminologies. The cytology and colposcopy performances were evaluated by sensitivity (SE), specificity (SP), positive predictive value (PPV), and negative predictive value (NPV) analyses with 95% confidence interval (95% CI

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Cytohistopathological correlation of Papanicolaou smears: a hospital based study

Cited by 9 publications

References 6 publications

Correlation of Cervical Pap Smear with Histopathological Diagnosis in Cervical Lesions: A 2 Years Retrospective Study

Correlation of Cervical Pap Smear with Histopathological Diagnosis in Cervical Lesions: A 2 Years Retrospective Study

A two year retrospective study of cytohistopathological correlation of cervical smear in a tertiary care hospital

Performance of Conventional Cytology and Colposcopy for the Diagnosis of Cervical Squamous and Glandular Neoplasias

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