Correlation of Cervical Pap Smear with Histopathological Diagnosis in Cervical Lesions: A 2 Years Retrospective Study

Abstract

Introduction: Cervical cancer is one of the most common forms of cancer worldwide. In developing countries, cancer of uterine cervix is ranked second with a relative frequency of 15% of all cancers in women. Screening women with regular Pap smears allows diagnosis of treatable pre-invasive lesions. The objective of the study was to correlate the Pap smear diagnosis with histopathology and to know the accuracy of Pap smears, so as to assess the efficacy of Pap smears in diagnosing cervical lesions. Material and methods: This two year retrospective study was done in the department of Pathology in a tertiary care centre, which includes 250 Pap smears for which histopathological diagnosis was also done. Detailed clinical history of patients was taken from requisition forms received in cytology department along with Pap smears. The cervical biopsies or hysterectomies received from the same patients were also studied and then correlated with the diagnosis of Pap smears. Results: Out of 250 Pap smears, maximum patients (32%) belonged to the age group of 41-50 years and were multipara. Maximum cases were reported as NILM (59%),followed by ASCUS (16%), LSIL (15%), HSIL (7%), squamous cell carcinoma (1.6%) and 0.8% cases of adenocarcinoma were diagnosed. On histopathology, 41.2% cases were diagnosed as chronic cervicitis, 27.2% cases as chronic cervicitis with squamous metaplasia, CIN I (22.4%),CIN II (4.0%),CIN III (2.8%), squamous cell carcinoma (1.6%) and (0.8)% cases of adenocarcinoma. Overall sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy was 75.24%, 97.98%, 96.20%, 85.38% and 88.8%. Conclusion: As per our study, maximum number of cases diagnosed on Pap smears correlated on histopathology, thereby concluding that Pap smears have an important role in diagnosis of cervical lesions.

A two year retrospective study of cytohistopathological correlation of cervical smear in a tertiary care hospital

“…8 The present study included 154 pap smear cases who also undergone biopsy or hysterectomy with most patients (35%) in the age group of 41-50 yrs and belong to para 2 (42%) followed by para 3 (25.6%). It has accordance with Sachan et al, 8 and Parija et al 9 The maximum number of patients presented with complaints of whitish discharge per vaginum (42%) and pain lower abdomen (35%) correlates with the study conducted by Bamanikar et al, 10 Atla et al, 11 and Bindroo et al 12 In our study out of 116 cases of NILM, 99% of cases correlated on histopathology which corroborated with the studies done by Atla et al, 11 and Bindroo et al 12 The incidence of Epithelial cell abnormality (ECA) was seen in 18.1% which correlated with Patil et al 13 But this incidence was higher than the study conducted by Malpani et al, 14 this may be because we had small sample size.…”

Cytohistopathological Correlation of 884 Cervical Pap Smears as Bethesda System 2014: A Hospital-Based Study

“…In the present study, we also found ASC-UC in most of the cases, accounting for7.1%. In addition, we found a cytohistological correlation in 56% of cases, with chronic cervicitis and squamous cell metaplasia in most of the patients (64.3%), but lower than the 93% and 91% reported in other studies [9,13]. The LSIL, HSIL and SCC were fully correlated with histopathology in the present study in available data which was comparable to another study [14].…”

“…The sensitivity, specificity, PPV, NPV and accuracy of the present study compared with other studies are shown in Table 5. The sensitivity of cervical smears reported in the present study (83.3%) was higher than that reported in other studies [8,10,13,[15][16][17]. The specificity reported in the present study (94.73%) was much higher than that reported by Patil et al, Bamanikar et [8,14,16,17].…”

“…We found 9.5% of cervical Pap smears were abnormal (intra-epithelial lesions), which was lower than the 16.86% of intra-epithelial lesions reported in the study by Warpe et al [12]. Bindroo et al reported epithelial abnormality in 40.4% of cases, the most common of which was ASC-US (15.6%) [13]. In the present study, we also found ASC-UC in most of the cases, accounting for7.1%.…”

Study of colposcopic and histopathological correlation for cervical lesion at tertiary care: An original research

“…Thus, this cancer is preventable and is amenable to detection by screening methods during early preinvasive stage. [6] Timing of diagnosis and extent of disease at the time of diagnosis determine the prognosis in cases of cervical cancer. Early diagnosis and management are associated with less intensive treatment, good outcome and reduced morbidity and mortality.…”