Cytohistomorphology of subcutaneous phaeohypomycosis

Mohapatra, Manisha; Satyanarayana, S

doi:10.4103/0970-9371.117651

Cited by 4 publications

(7 citation statements)

References 6 publications

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“…In the present case, the species delineated was Exophiala dermatitidis . It presents as a disseminated disease or as focal involvement of one or more systems: sinusitis, onychomycosis, subcutaneous lump, corneal inflammation, osteomyelitis, pneumonia, cerebral abscesses, lung, heart and skin . The rare case involving hard palate has been reported by Yeshwent et al The present case presented with a lump in the breast which is extremely rare and on the extensive literature search, no case with similar presentation could be found on FNAC.…”

Section: Discussionmentioning

confidence: 48%

“…It presents as a disseminated disease or as focal involvement of one or more systems: sinusitis, onychomycosis, subcutaneous lump, corneal inflammation, osteomyelitis, pneumonia, cerebral abscesses, lung, heart and skin. [1][2][3][4][5] The rare case involving hard palate has been reported by Yeshwent et al 6 The pres- We report a rare case of phaeohyphomycosis presenting as a breast lump masquerading as fibroadenoma which has not been reported in the literature. The awareness of such organisms in cytology smears will fasten the diagnosis leading to early treatment which is a necessity, especially in disseminated cases as the disease has high morbidity and mortality.…”

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confidence: 78%

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Phaeohyphomycosis breast masquerading as fibroadenoma in a young teenage girl

Gupta

Singh

Yadav

et al. 2017

Diagnostic Cytopathology

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Phaeohyphomycosis is an unusual granulomatous fungal infection, observed in immunocompromised or diabetic patients; however, it is even rarer in immunocompetent patients. Cytological findings of the same have been infrequently reported. The histopathological diagnosis or fungal culture helps in definitive diagnosis to identify the exact fungal species. Hereby, we report a rare case of invasive fungal infection in a breast lump in a young female, presenting as fibroadenoma breast. Fine needle aspiration cytology from the breast lesion showed the presence of septate acute-angled branching fungal hyphae with focal pigmentation, morphologically suggestive of phaeohyphomycosis which was positive with fungal stains. This was later confirmed on biopsy as histopathology slides showed the presence of prominent pigmented fungal hyphae. The pus culture from needle aspirate also showed phaeohyphomycotic fungal organism delineating the species Exophiala dermatitidis. Aspiration cytology is crucial for the diagnosis of fungal infection in such cases. An appropriate diagnosis will help in early detection and treatment of such infections as these are usually associated with high morbidity and mortality.

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Section: Discussionmentioning

confidence: 48%

mentioning

confidence: 78%

Phaeohyphomycosis breast masquerading as fibroadenoma in a young teenage girl

Gupta

Singh

Yadav

et al. 2017

Diagnostic Cytopathology

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“…On fine needle aspiration, mostly pus is aspirated, and smears show fungal profiles in a background of inflammatory cells, giant cells, and necrotic debris [14]. The hyphae are slender, having variable length and irregular breadth.…”

Section: Discussionmentioning

confidence: 99%

“…Differential diagnoses of phaeohyphomycosis include chromoblastomycosis and mycetoma, although some confusion with Aspergillus and Mucoromycetes may occur [2, 14, 15]. Patients with mycetoma clinically present with discharging sinuses and granules, unlike cases of phaeohyphomycosis, where the overlying skin is usually intact.…”

Section: Discussionmentioning

confidence: 99%

Phaeohyphomycosis: Cytomorphologic Evaluation in Eleven Cases

et al. 2020

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Phaeohyphomycosis caused by phaeoid fungi is a type of mycosis emerging worldwide which causes a wide variety of clinical manifestations. Study Design: A retrospective analysis of 11 cases diagnosed with fungal inflammation on cytology over a period of 6 years (2013-2018) was done along with culture/histopathologic confirmation. Results: Of the total of 11 cases, 9 cases presented with subcutaneous swellings and 1 case each with brain and lung lesions. The age range was 30-83 years (mean: 53.6); 8 patients were male and 3 were female. Cytologic smears showed fungal profiles with septate tortuous hyphae, as well as swollen and narrow, yeast-like swellings with an irregular breadth of the hyphae in all cases. The fungal profiles were visualized on a Masson-Fontana stain. The background showed inflammatory cells, giant cells, and necrosis in variable proportions. Five cases were diagnosed as phaeohyphomycosis on cytology, whereas 3 cases were misdiagnosed as aspergillus and 2 as candida. In 1 case, typing of the fungus was not done. Histopathology was available in 5 cases, and in all these a diagnosis of phaeohyphomycosis was reached. Ten of the 11 cases had confirmation on fungal culture. Conclusions: Phaeoid fungi are rarely seen in routine cytologic practice. Careful evaluation of cytologic smears and an awareness of the characteristic morphologic features of phaeohyphomycosis are helpful in arriving at a correct diagnosis. Fine needle aspiration cytology provides a rapid diagnosis, enabling prompt therapy.

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“…Melanised or dematiaceous fungi are differentiated into three types based on the histologic findings i.e., eumycetoma, chromoblastomycosis and phaeohypomycosis. In histology sections, eumycetoma shows the presence of grains which are closely packed fungal hyphae; whereas, chromoblastomycosis shows sclerotic bodies consisting of thick walled muriform cells 1 . Phaeohypomycosis is characterized by the presence of dark brown mycelial structures in the involved tissue, which distinguishes it from the other clinical categories of disease caused by brown pigmented fungi 1 .…”

Section: Discussionmentioning

confidence: 99%

Phaeohyphomycosis of Lower Limb

Chakma¹,

Kolte²,

Sharma³

et al. 2019

APALM

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Phaeohyphomycosis is a chronic, progressive cutaneous and subcutaneous infection caused by melanised or dermaticeous fungi and characterized by the presence of brown mycelial structures on fine needle aspiration cytology. These fungi are associated with rural population, involved in various agricultural and outdoor activities. The clinical manifestations that includes superficial and deep local infection to disseminated infection. Herein, we describe the clinical and fine-needle aspiration cytology features of a case of phaeohyphomycosis caused by Phialophora verrucosa.

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Cytohistomorphology of subcutaneous phaeohypomycosis

Cited by 4 publications

References 6 publications

Phaeohyphomycosis breast masquerading as fibroadenoma in a young teenage girl

Phaeohyphomycosis breast masquerading as fibroadenoma in a young teenage girl

Phaeohyphomycosis: Cytomorphologic Evaluation in Eleven Cases

Phaeohyphomycosis of Lower Limb

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