Cytogenetic study of bone marrow and blood cells in patients with non-hodgkin lymphoma before and after antitumor therapy

Abstract

Non-clonal and clonal abnormal cells (hypodiploid, polyploid, and with chromosome aberrations) were detected by the G-method in the bone marrow and blood of the majority of patients with non-Hodgkin lymphomas before therapy. The manifestation of these abnormalities changed individually after treatment. The most incident were clones -22, del(1)(q42-43), del(2)(q-33-35), del(3)(q27), 4q-, and del(6q).

Transient myelodysplastic syndrome in X‐linked agammaglobulinemia with a novel Btk mutation

“…Some of them evolved into MDS, while others had single cytopenias, lymphoproliferative disorders or plasma cell dyscrasias 12, 13. Clonal and non‐clonal cytogenetic abnormalities have also been found in marrows of relatively immunosuppressed patients with conditions such as lymphomas 14. The association of clonal cytogenetic abnormalities in bone marrow failure syndromes such as Fanconi anemia and Paroxysmal Nocturnal Hemoglobinuria is well documented 15.…”