Cytogenetic Studies in Myelofibrosis Experience in Western Australia, 1963‐1970

Woodliff, H. J.; Chipper, L.; Gallon, Winifred

doi:10.5694/j.1326-5377.1972.tb116643.x

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1974

1976

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Blastic phase of agnogenic myeloid metaplasia simulating malignant lymphoma

Cehreli

Ezdinli

et al. 1976

Cancer

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A patient with agnogenic myeloid metaplasia in blastic transformation with unusually prominent lymphadenopathy simulating lymphoma is described. Interestingly, the initial evidence of myeloblastic transformation was present in the lymph nodes but not in the marrow. Serial bone marrow biopsies showed fibrosis throughout the course of the disease, in spite of a gradual increase in the percentage of peripheral blood myeloblasts. Aneuploidy with a marker chromosome and a Philadelphia-like chromosome was present in the lymph node, bone marrow, and peripheral blood cells. The literature is reviewed regarding the incidence of prominent lymphadenopathy and chromosome abnormalities in agnogenic myeloid metaplasia and other myeloproliferative disorders.

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