Blastic phase of agnogenic myeloid metaplasia simulating malignant lymphoma

Abstract

A patient with agnogenic myeloid metaplasia in blastic transformation with unusually prominent lymphadenopathy simulating lymphoma is described. Interestingly, the initial evidence of myeloblastic transformation was present in the lymph nodes but not in the marrow. Serial bone marrow biopsies showed fibrosis throughout the course of the disease, in spite of a gradual increase in the percentage of peripheral blood myeloblasts. Aneuploidy with a marker chromosome and a Philadelphia-like chromosome was present in the lymph node, bone marrow, and peripheral blood cells. The literature is reviewed regarding the incidence of prominent lymphadenopathy and chromosome abnormalities in agnogenic myeloid metaplasia and other myeloproliferative disorders.

Allogeneic bone marrow transplantation for agnogenic myeloid metaplasia

“…Furthermore, although the course of the disease is usually chronic, the median survival has been evaluated at 5 years (Nakai et al, 1962;Pitcock et al, 1962;Ward & Block, 1971;Varki et al, 1983;Hasselbalch, 1990;Visani et al, 1990;Thiele et al, 1992;Dupriez et al, 1996). Although less frequent than during chronic myelogenous leukaemia, blastic transformation, which occurs in 4-28% of AMM, is one of the major causes of death (Cehrelli et al, 1976;Rosenthal & Molony, 1977;Marcus et al, 1986;Garcia et al, 1989;Barosi et al, 1995;Kimura et al, 1995). This is of particular concern since no current treatment has shown an ability to cure or even to prolong survival of these patients.…”

Hodgkin’s disease and intercurrent processes that may simulate a relapse

“…These may be erroneously interpreted as persistence of lymphoma or other sarcoid-like reactions, intrathoracic lymphadenopathy and pulmonary parenchymal disease [1] or, most commonly, thymic hyperplasia [2]. Our patient developed a still more infrequent condition: agnogenic myeloid metaplasia, simulating lymphoma [3].…”

Acute myelofibrosis terminating in an acute lymphoblastic leukemia. A case report

“…The blood was centrifuged in a Ficoll-Hypaque gradient . 5 The interphase cells were examined as to their ability to form rosettes with sheep red blood cells (a characteristic of T cells) and their surface immunoglobulins (a characteristic of B cells) as well as for their expression of human B lymphocyte antigens-(HBLA) or T-lymphocyte antigens (HTLA). The latter was determined by means of an indirect immunofluorescent technique using fluorescein conjugated rabbit anti-HBLA or anti-HTLA antiserum.…”