Cytogenetic findings in 111 ovarian cancer patients: Therapy-related chromosome aberrations and heterochromatic variants

Islam, Mohammad Mirazul; Köpf, I; Levan, Albert; Granberg, S.; Friberg, Lars Göran; Levan, Göran

doi:10.1016/0165-4608(93)90056-r

Cited by 10 publications

(1 citation statement)

References 56 publications

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“…Monosomy 7, 7q-, and unbalanced translocation including chromosome 7 were observed in patients who received anthracycline-containing chemotherapy [43] . Moreover, structural chromosomal aberrations of chromosomes 1, 9 and 16 have been related to chemotherapeutic drugs containing anthracycline [44] .…”

Section: Discussionmentioning

confidence: 99%

Aneugenic Effects of Epirubicin in Somatic and Germinal Cells of Male Mice

et al. 2014

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The ability of the antineoplastic agent epirubicin to induce aneuploidy and meiotic delay in the somatic and germinal cells of male mice was investigated by fluorescence in situ hybridization assay using labeled DNA probes and BrdU-incorporation assay. Mitomycin C and colchicine were used as positive controls for clastogen and aneugen, respectively, and these compounds produced the expected responses. The fluorescence in situ hybridization assay with a centromeric DNA probe for erythrocyte micronuclei showed that epirubicin is not only clastogenic but also aneugenic in somatic cells in vivo. By using the BrdU-incorporation assay, it could be shown that the meiotic delay caused by epirubicin in germ cells was approximately 48 h. Disomic and diploid sperm were shown in epididymal sperm hybridized with DNA probes specific for chromosomes 8, X and Y after epirubicin treatment. The observation that XX- and YY-sperm significantly prevailed over XY-sperm indicates missegregation during the second meiotic division. The results also suggest that earlier prophase stages contribute less to epirubicin-induced aneuploidy. Both the clastogenic and aneugenic potential of epirubicin can give rise to the development of secondary tumors and abnormal reproductive outcomes in cured cancer patients and medical personnel exposed to epirubicin.

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Section: Discussionmentioning

confidence: 99%

Aneugenic Effects of Epirubicin in Somatic and Germinal Cells of Male Mice

et al. 2014

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Specific numerical chromosomal aberrations induced by adriamycin

Aly

Othman

Nahas

1999

Environ. Mol. Mutagen.

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Fluorescence in situ hybridization with 7, 17, X, and Y chromosome‐specific DNA probe was used to investigate the ability of Adriamycin (AM) to induce aneuploidy in interphase human lymphocytes. The reliability of the probes was tested by hybridization to metaphases and interphase nuclei of untreated normal lymphocytes. Two signals were scored in over 87% of the analyzed nuclei with chromosome 7 and 17 probes, whereas one signal was recorded in over 86% of the nuclei with chromosomes X and Y. The same conditions and probe concentrations were used for hybridizing the four probes to interphase nuclei of AM‐treated and untreated lymphocytes, cultured from healthy individuals and cancer patients. AM was found to induce significant increases of trisomy 7 and 17 in lymphocytes cultured from healthy individuals and cancer patients, where the interphase nuclei showed three spots in over 70% and 72% of the cells, respectively. Only 6% of interphase nuclei of untreated cells cultured from healthy individuals and cancer patients showed three spots. No significant increase in X or Y aneuploidy was induced by exposure to AM. Environ. Mol. Mutagen. 33:161–166, 1999 © 1999 Wiley‐Liss, Inc.

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