Cytogenetic Effects of Cyclamates

Jemison, E.; Brown, Kenneth S.; Rivers, Beverly; Knight, Regina

doi:10.1007/978-1-4615-9376-8_6

Cited by 4 publications

(1 citation statement)

References 9 publications

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“…Gurney et al (1997) and Schwartz (1999) reported that aspartame also has a carcinogenic effect. On the other hand, it was reported that there are a lot of artificial or natural sweeteners that have genotoxic and carcinogenic effects (Brusick et al, 1989; Compadre et al, 1988; Dragsted et al, 2002; Hansen et al, 2004; Jemison et al, 1984; Kruger et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

The genotoxic and teratogenic effects of maltitol in rats

Canimoĝlu

Rencüzoğulları

2012

Toxicol Ind Health

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In the present study, the genotoxic and cytotoxic effects of the low-caloric artificial sweetener maltitol, which is a sugar alcohol (polyol), were investigated in the bone marrow cells of rats using the chromosome aberration (CA) test. In addition, the teratogenicity and embryotoxicity of maltitol was also investigated in rats. To reveal the genotoxicity and cytotoxicity of maltitol, rats were intraperitoneally administered 2.5, 5 and 10 g/kg body weight (bw) concentrations of maltitol for 6, 12 and 24 h treatment period. The pregnant females were intraperitoneally treated with 1, 2 and 4 g/kg bw/day concentrations of maltitol during the first 7 days of gestation (first trimester) to investigate the teratogenicity of maltitol. The embryos were collected after killing the dams by cervical dislocation under ether anaesthesia on gestation day 19. Maltitol did not induce the CA and did not decrease the mitotic index in bone marrow cells of rats at all concentrations and treatment periods. In addition, maltitol was not teratogenic; however, it decreased the foetuses weight and at the highest dose (4 g/kg bw) caused growth retardation.

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Section: Introductionmentioning

confidence: 99%

The genotoxic and teratogenic effects of maltitol in rats

Canimoĝlu

Rencüzoğulları

2012

Toxicol Ind Health

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The Cytogenetic Effects of Food Sweetener Maltitol in Human Peripheral Lymphocytes

Canimoĝlu

Rencüzoğulları

2006

Drug and Chemical Toxicology

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The effects of the low-calorie artifical sweetener maltitol (E965), a sugar alcohol (Polyol), on sister chromatid exchange (SCE), chromosome aberration (CA), and micronucleus formation (MN) were investigated in human peripheral lymphocytes. Maltitol did not induce SCE at all concentrations (1.25, 2.5, and 5 mg/mL) and treatment periods (24 and 48 h). Maltitol induced CA, although not statistically significantly. Maltitol induced the frequency of MN at 24 and 48 h in a non-dose-dependent manner. In addition, maltitol did not decrease the replication index (RI) and the mitotic index (MI) at all concentrations and treatment periods. Maltitol did not alter the pH and osmolality of the medium. In conclusion, it can be concluded that maltitol has a weak genotoxic potential and it appears non-cytotoxic to human peripheral lymphocytes in vitro.

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Toxicological aspects of cyclamate and cyclohexylamine

Bopp

Sonders

Kesterson

et al. 1986

CRC Critical Reviews in Toxicology

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In the late 1960s the artificial sweetener cyclamate was implicated as a bladder carcinogen in rats. This finding and other concerns about its safety ultimately led to a ban on cyclamate in the U.S. and restrictions on its use in many other countries. Since that time, the carcinogenic potential of cyclamate and cyclohexylamine, its principal metabolite, has been reevaluated in a group of well-controlled, well-designed bioassays that have failed to substantiate the earlier findings. This review of the published and unpublished literature on cyclamate attempts to evaluate the carcinogenicity question and other important aspects of the toxicity of cyclamate and cyclohexylamine, including their effects on various organ systems, their genotoxic potential, and their effects on reproduction. In addition, the physiological disposition of cyclamate is reviewed, with particular attention directed toward the site and extent of its conversion to cyclohexylamine.

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Cytogenetic Effects of Cyclamates

Cited by 4 publications

References 9 publications

The genotoxic and teratogenic effects of maltitol in rats

The genotoxic and teratogenic effects of maltitol in rats

The Cytogenetic Effects of Food Sweetener Maltitol in Human Peripheral Lymphocytes

Toxicological aspects of cyclamate and cyclohexylamine

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