Cytogenetic and clinicobiological features of acute leukemia with stem cell phenotype: Study of nine cases

Cuneo, Antonio; Ferrant, A; Michaux, Jean‐Louis; Bosly, André; Châtelain, Bernard; Stul, Michel; Cin, Paola Dal; Dierlamm, Judith; Cassiman, Jean‐Jacques; Hossfeld, Dieter K.; Castoldi, Gianluigi; Berghe, Herman Van den

doi:10.1016/s0165-4608(96)00127-6

Cited by 26 publications

(21 citation statements)

References 23 publications

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“…Such cases often express CD34, HLA-DR, and/or CD38, and sometimes TdT, but lack specific myeloid or lymphoid antigens. [111][112][113] Leukemias with blasts that coexpress certain antigens of more than one lineage on the same cells or that have separate populations of blasts that are of different lineages are referred to as mixed phenotype acute leukemia (MPAL). These cases may be further designated as B-myeloid or T-myeloid, irrespective of whether one or more than one population of blasts is found.…”

Section: Acute Leukemia Of Ambiguous Lineagementioning

confidence: 99%

The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes

Vardiman

Thiele

Arber

et al. 2009

Blood

3,867

3,157

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1 That classification reflected a paradigm shift from previous schemes in that, for the first time, genetic information was incorporated with morphologic, cytochemical, immunophenotypic, and clinical information into diagnostic algorithms for the myeloid neoplasms. The 2001WHO classification was prefaced with a comment predicting that future revisions would be necessary because of rapidly emerging genetic and biologic information. Recently, a revised classification has been published as part of the 4th edition of the WHO monograph series. 2 The aim of the revision was to incorporate new scientific and clinical information to refine diagnostic criteria for previously described neoplasms and to introduce newly recognized disease entities. Our purpose in this communication is to highlight major changes in the revised WHO classification of myeloid neoplasms and acute leukemia and to provide the rationale for those changes.

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Section: Acute Leukemia Of Ambiguous Lineagementioning

confidence: 99%

The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes

Vardiman

Thiele

Arber

et al. 2009

Blood

3,867

3,157

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“…Cytogenetic abnormalities are very common in ALAL. Cytogenetic analysis reveals clonal chromosomal abnormalities in 59–91% of patients with MPAL (Lee et al , ; Al‐Seraihy et al , ; Gerr et al , ; Atfy et al , ; Matutes et al , ; Bhatia et al , ; Yan et al , ) and in 80–90% of patients with AUL (Cuneo et al , ; Heesch et al , ). Clonal chromosome abnormalities are numerical (involving changes in chromosome number), structural (including mainly translocations and deletions) or both numerical and structural.…”

Section: The Significance Of Cytogenetics In Alalmentioning

confidence: 99%

Cytogenetic abnormalities in acute leukaemia of ambiguous lineage: an overview

Manola

2013

Br J Haematol

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Summary Acute leukaemia of ambiguous lineage (ALAL) is a rare complex entity with heterogeneous clinical, immunophenotypic, cytogenetic and molecular genetic features and adverse outcome. According to World Health Organization 2008 classification, ALAL encompasses those leukaemias that show no clear evidence of differentiation along a single lineage. The rarity of ALAL and the lack of uniform diagnostic criteria have made it difficult to establish its cytogenetic features, although cytogenetic analysis reveals clonal chromosomal abnormalities in 59–91% of patients. This article focuses on the significance of cytogenetic analysis in ALAL supporting the importance of cytogenetic analysis in the pathogenesis, diagnosis, prognosis, follow up and treatment selection of ALAL. It reviews in detail the types of chromosomal aberrations, their molecular background, their correlation with immunophenotype and age distribution and their prognostic relevance. It also summarizes some novel chromosome aberrations that have been observed only once. Furthermore, it highlights the ongoing and future research on ALAL in the field of cytogenetics.

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“…Additionally, Arber et al recently reported immunoreactivity with Four of the eight patients in our series with lymphoid morphology and cytochemical staining but myeloid immunophenotypes had trisomy or tetrasomy of chromosomes 13q/13 and/or 12q/12. Trisomy 13/13q has previously been associated with morphologically undifferentiated leukemia and mixed lineage leukemia (13)(14)(15). Trisomy 12 is characteristic of chronic lymphocytic leukemia, with an incidence of up to 20% (16), but has also been reported in both AML and ALL (17,18).…”

Section: Discussionmentioning

confidence: 99%

“…Trisomy 12 is characteristic of chronic lymphocytic leukemia, with an incidence of up to 20% (16), but has also been reported in both AML and ALL (17,18). Like trisomy 13/13q, trisomy 12/12q has also been associated with undifferentiated acute leukemia (15). Reciprocal chromosome translocations with 11q23 breakpoints, involving the MLL gene, are found in both AML and ALL (18).…”

Section: Discussionmentioning

confidence: 99%

Routine immunophenotyping in acute leukemia: Role in lineage assignment and reassignment

Qadir

Barcos

Stewart

et al. 2006

Cytometry Part B Clinical

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Cytogenetic and clinicobiological features of acute leukemia with stem cell phenotype: Study of nine cases

Cited by 26 publications

References 23 publications

The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes

The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes

Cytogenetic abnormalities in acute leukaemia of ambiguous lineage: an overview

Routine immunophenotyping in acute leukemia: Role in lineage assignment and reassignment

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