Cytocompatible and multifunctional polymeric nanoparticles for transportation of bioactive molecules into and within cells

Ishihara, Kazuhíko; Chen, Weixin; Liu, Yihua; Tsukamoto, Yuriko; Inoue, Yasuo

doi:10.1080/14686996.2016.1190257

Cited by 32 publications

(17 citation statements)

References 103 publications

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“…By analogy with computational optimizations of efficiency and function of novel cyber technologies such as machine learning [1][2][3][4][5], the optimization of structure, combination, and organization of materials towards advanced functionality based on accumulated knowledge, theories, facts, experiences, and intuitions must continue [6][7][8][9]. Current societal demands including materials synthesis and production [10][11][12][13][14], energy storage and conversion [15][16][17][18][19][20][21][22], analyte sensing and detection [23][24][25][26], environmental remediation [27][28][29][30], and biological and biomedical applications [31][32][33][34][35][36] are currently being met through developments in the science and technology of advanced materials.…”

Section: Introductionmentioning

confidence: 99%

Self-assembly as a key player for materials nanoarchitectonics

Ariga

Nishikawa

Mori

et al. 2019

Science and Technology of Advanced Materials

351

255

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The development of science and technology of advanced materials using nanoscale units can be conducted by a novel concept involving combination of nanotechnology methodology with various research disciplines, especially supramolecular chemistry. The novel concept is called 'nanoarchitectonics' where self-assembly processes are crucial in many cases involving a wide range of component materials. This review of self-assembly processes reexamines recent progress in materials nanoarchitectonics. It is composed of three main sections: (1) the first short section describes typical examples of self-assembly research to outline the matters discussed in this review; (2) the second section summarizes self-assemblies at interfaces from general viewpoints; and (3) the final section is focused on self-assembly processes at interfaces. The examples presented demonstrate the strikingly wide range of possibilities and future potential of self-assembly processes and their important contribution to materials nanoarchitectonics. The research examples described in this review cover variously structured objects including molecular machines, molecular receptors, molecular pliers, molecular rotors, nanoparticles, nanosheets, nanotubes, nanowires, nanoflakes, nanocubes, nanodisks, nanoring, block copolymers, hyperbranched polymers, supramolecular polymers, supramolecular gels, liquid crystals, Langmuir monolayers, Langmuir-Blodgett films, self-assembled monolayers, thin films, layer-by-layer structures, breath figure motif structures, two-dimensional molecular patterns, fullerene crystals, metal-organic frameworks, coordination polymers, coordination capsules, porous carbon spheres, mesoporous materials, polynuclear catalysts, DNA origamis, transmembrane channels, peptide conjugates, and vesicles, as well as functional materials for sensing, surface-enhanced Raman spectroscopy, photovoltaics, charge transport, excitation energy transfer, lightharvesting, photocatalysts, field effect transistors, logic gates, organic semiconductors, thin-film-based devices, drug delivery, cell culture, supramolecular differentiation, molecular recognition, molecular tuning, and hand-operating (hand-operated) nanotechnology.

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Section: Introductionmentioning

confidence: 99%

Self-assembly as a key player for materials nanoarchitectonics

Ariga

Nishikawa

Mori

et al. 2019

Science and Technology of Advanced Materials

351

255

View full text Add to dashboard Cite

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“…This suggests that the presence of BP on the SS surface was less favorable for cell survival. The cell biocompatibility of all samples was higher than 80%, although the SS-BP group was lower than other groups, but still within acceptable limits for implantable devices [46].…”

Section: Resultsmentioning

confidence: 99%

Osteoblast Biocompatibility and Antibacterial Effects Using 2-Methacryloyloxyethyl Phosphocholine-Grafted Stainless-Steel Composite for Implant Applications

Chen

Luo

et al. 2019

Nanomaterials

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Poor osteogenesis and bacterial infections lead to an implant failure, so the enhanced osteogenic and antimicrobial activity of the implantable device is of great importance in orthopedic applications. In this study, 2-methacryloyloxyethyl phosphocholine (MPC) was grafted onto 316L stainless steel (SS) using a facile photo-induced radical graft polymerization method via a benzophenone (BP) photo initiator. Atomic force microscopy (AFM) was employed to determine the nanoscale morphological changes on the surface. The grafted BP-MPC layer was estimated to be tens of nanometers thick. The SS-BP-MPC composite was more hydrophilic and smoother than the untreated and BP-treated SS samples. Staphylococcus aureus (S. aureus) bacteria binding onto the SS-BP-MPC composite film surface was significantly reduced compared with the pristine SS and SS-BP samples. Mouse pre-osteoblast (MC3T3-E1) cells showed good adhesion on the MPC-modified samples and better proliferation and metabolic activity (73% higher) than the pristine SS sample. Biological studies revealed that grafting MPC onto the SS substrate enhanced the antibacterial efficiency and also retained osteoblast biocompatibility. This proposed procedure is promising for use with other implant materials.

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“…They are organic chemical substances composed of repeated units called “monomers” whereby they are mainly categorized as synthetic or natural. Macromolecules should present biocompatibility and histocompatibility, hydrolytic degradation producing non-toxic monomers as well as other chemical properties in order to be characterized as optimal candidates in pharmaceutical technology [ 237 , 238 ]. NCs consisting of polymers can be applied in several forms, such as nanoparticles, nanocapsules, nanofibers and nanogels.…”

Section: Types Of Nanocarriersmentioning

confidence: 99%

Surface Modified Multifunctional and Stimuli Responsive Nanoparticles for Drug Targeting: Current Status and Uses

Sıafaka

Okur

Karavas

et al. 2016

IJMS

156

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Nanocarriers, due to their unique features, are of increased interest among researchers working with pharmaceutical formulations. Polymeric nanoparticles and nanocapsules, involving non-toxic biodegradable polymers, liposomes, solid lipid nanoparticles, and inorganic–organic nanomaterials, are among the most used carriers for drugs for a broad spectrum of targeted diseases. In fact, oral, injectable, transdermal-dermal and ocular formulations mainly consist of the aforementioned nanomaterials demonstrating promising characteristics such as long circulation, specific targeting, high drug loading capacity, enhanced intracellular penetration, and so on. Over the last decade, huge advances in the development of novel, safer and less toxic nanocarriers with amended properties have been made. In addition, multifunctional nanocarriers combining chemical substances, vitamins and peptides via coupling chemistry, inorganic particles coated by biocompatible materials seem to play a key role considering that functionalization can enhance characteristics such as biocompatibility, targetability, environmental friendliness, and intracellular penetration while also have limited side effects. This review aims to summarize the “state of the art” of drug delivery carriers in nanosize, paying attention to their surface functionalization with ligands and other small or polymeric compounds so as to upgrade active and passive targeting, different release patterns as well as cell targeting and stimuli responsibility. Lastly, future aspects and potential uses of nanoparticulated drug systems are outlined.

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Cytocompatible and multifunctional polymeric nanoparticles for transportation of bioactive molecules into and within cells

Cited by 32 publications

References 103 publications

Self-assembly as a key player for materials nanoarchitectonics

Self-assembly as a key player for materials nanoarchitectonics

Osteoblast Biocompatibility and Antibacterial Effects Using 2-Methacryloyloxyethyl Phosphocholine-Grafted Stainless-Steel Composite for Implant Applications

Surface Modified Multifunctional and Stimuli Responsive Nanoparticles for Drug Targeting: Current Status and Uses

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