Cytocompatibility evaluation of microwave sintered biphasic calcium phosphate scaffolds synthesized using pH control

Wagner, Darcy E.; Jones, Andrew D.; Zhou, Huan; Bhaduri, Sarit B.

doi:10.1016/j.msec.2012.12.084

Cited by 20 publications

(8 citation statements)

References 44 publications

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“…It can be processed into a fine powder 60 and applied for use in a novel 3D sintering method that rather utilizes microwaves, as heat was utilized for scaffold fabrication. 60,61 Sintered TCP scaffolds exhibited an increase in compressive strength and more optimal microporosity: macroporosity ratio, which, in turn, increased the formation of new bone in vivo when compared with constructs fabricated through a conventional energy source. 60 Recently, a company called Oxford Performance Materials used SLS and a proprietary poly(ether-keytone-ketone) (deemed OPEKK-IG) biomimetic polymer to create a bone substitute designed for use in craniofacial defects.…”

Section: Three-dimensional Printing Bonementioning

confidence: 99%

Three-Dimensional Printing of Nanomaterial Scaffolds for Complex Tissue Regeneration

O’Brien

Holmes

Faucett

et al. 2015

Tissue Engineering Part B: Reviews

190

145

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Three-dimensional (3D) printing has recently expanded in popularity, and become the cutting edge of tissue engineering research. A growing emphasis from clinicians on patient-specific care, coupled with an increasing knowledge of cellular and biomaterial interaction, has led researchers to explore new methods that enable the greatest possible control over the arrangement of cells and bioactive nanomaterials in defined scaffold geometries. In this light, the cutting edge technology of 3D printing also enables researchers to more effectively compose multi-material and cell-laden scaffolds with less effort. In this review, we explore the current state of 3D printing with a focus on printing of nanomaterials and their effect on various complex tissue regeneration applications.

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Section: Three-dimensional Printing Bonementioning

confidence: 99%

Three-Dimensional Printing of Nanomaterial Scaffolds for Complex Tissue Regeneration

O’Brien

Holmes

Faucett

et al. 2015

Tissue Engineering Part B: Reviews

190

145

View full text Add to dashboard Cite

show abstract

“…All corresponding peaks were identified using Jade™ (Materials Data Inc., Livermore, California) software and labeled. 23 The morphological features of precipitates were studied using a SEM at 10 kV voltage, and all samples were gold coated for about 30 s before the SEM. The grain size of sintered polycrystalline specimens was determined from SEM micrographs using image J (developed at the National Institutes of Health).…”

Section: Characterizationmentioning

confidence: 99%

“…It has been found that nanotopographical features like nanopores in scaffolds can also suit the cellular attachment and proliferation like microspores one. 23 The average particle sizes (from SEM images) in the sintered sample of H1, H2, and H3 are shown in Figs. 4(a)-4(c).…”

Section: B Microstructural Evolution and Grain Sizementioning

confidence: 99%

Microwave sintering of fine grained MgP and Mg substitutes with amorphous tricalcium phosphate: Structural, and mechanical characterization

2016

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This paper, for the first time, reports the results of microwave sintering of two emerging biomaterials, magnesium phosphate and amorphous magnesium calcium phosphate. Beneficial aspects of successful microwave sintering of calcium phosphate are well documented in the literature. The motivation for this work derives from the absence of any publication of similar nature on magnesium phosphates, which are becoming important with the rapid rise in interest in biodegradable Mg-alloys. Starting off with amorphous calcium magnesium phosphate and magnesium phosphate, the resulting microwave sintered product is a biphasic mixture of whitlockite substituted with magnesium and magnesium phosphate. The influence of the extent of Mg substitution on the mechanical properties, microstructure, and sintering behavior of tricalcium phosphate was evaluated. The results showed that the addition of Mg (up to the 50% wt/wt in relation to Ca mass) in the precursor compound of magnesium calcium phosphate improved the kinetics of the densification process and enhanced hardness values.

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“…Calcium phosphate ceramics have suitable osteoconductivity and biocompatibility for bone tissue engineering. b-TCP is currently one of the most frequently used calcium phosphates for bone tissue application [10,[13][14][15][16]. In addition to being biodegradable, osteoconductive and resorbable, b-TCP has a Ca/P ratio similar to that of natural bone [6,[17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Nanocomposite Scaffolds (Collagen/β-TCP/SrO) for Bone Tissue Engineering

Goodarzi

Hashemi‐Najafabadi

Baheiraei

et al. 2019

Tissue Eng Regen Med

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BACKGROUND: Nowadays, production of nanocomposite scaffolds based on natural biopolymer, bioceramic, and metal ions is a growing field of research due to the potential for bone tissue engineering applications. METHODS: In this study, a nanocomposite scaffold for bone tissue engineering was successfully prepared using collagen (COL), beta-tricalcium phosphate (b-TCP) and strontium oxide (SrO). A composition of b-TCP (4.9 g) was prepared by doping with SrO (0.05 g). Biocompatible porous nanocomposite scaffolds were prepared by freeze-drying in different formulations [COL, COL/b-TCP (1:2 w/w), and COL/b-TCP-Sr (1:2 w/w)] to be used as a provisional matrix or scaffold for bone tissue engineering. The nanoparticles were characterized by X-ray diffraction, Fourier transforms infrared spectroscopy and energy dispersive spectroscopy. Moreover, the prepared scaffolds were characterized by physicochemical properties, such as porosity, swelling ratio, biodegradation, mechanical properties, and biomineralization. RESULTS: All the scaffolds had a microporous structure with high porosity (* 95-99%) and appropriate pore size (100-200 lm). COL/b-TCP-Sr scaffolds had the compressive modulus (213.44 ± 0.47 kPa) higher than that of COL/b-TCP (33.14 ± 1.77 kPa). In vitro cytocompatibility, cell attachment and alkaline phosphatase (ALP) activity studies performed using rat bone marrow mesenchymal stem cells. Addition of b-TCP-Sr to collagen scaffolds increased ALP activity by 1.33-1.79 and 2.92-4.57 folds after 7 and 14 days of culture, respectively. CONCLUSION: In summary, it was found that the incorporation of Sr into the collagen-b-TCP scaffolds has a great potential for bone tissue engineering applications.

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Cytocompatibility evaluation of microwave sintered biphasic calcium phosphate scaffolds synthesized using pH control

Cited by 20 publications

References 44 publications

Three-Dimensional Printing of Nanomaterial Scaffolds for Complex Tissue Regeneration

Three-Dimensional Printing of Nanomaterial Scaffolds for Complex Tissue Regeneration

Microwave sintering of fine grained MgP and Mg substitutes with amorphous tricalcium phosphate: Structural, and mechanical characterization

Preparation and Characterization of Nanocomposite Scaffolds (Collagen/β-TCP/SrO) for Bone Tissue Engineering

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