Cytocompatibility and Mechanical Properties of Hydroxyapatite Composite Reinforced with Multi-Walled Carbon Nanotubes and Bovine Serum Albumin

Gholami, Fatemeh; Zein, Sharif Hussein Sharif; Ismail, Suzylawati; Tan, Soon Huat

doi:10.12691/ces-2-1-1

Cited by 18 publications

(1 citation statement)

References 16 publications

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“…A small change in compressive strength for the HA-alginate-0.05 SWCNT sample is explained by the small volume of interfacial areas of the HA-alginate-0.05SWCNT and ineffective process of loading transfer between HA-alginate and SWCNT. At the same time, the increase of SWCNT content (0.5%) provides a large volume of interfacial areas in HA-alginate-0.5SWCNT and increases compressive strength as a result of good interfacial adhesion between the composite components and efficient transferring the load from the HA-alginate matrix to the SWCNT, leading to the improvement of the mechanical properties (Gholami et al 2014;Skwarek et al 2017).…”

Section: Resultsmentioning

confidence: 99%

Single-walled carbon nanotubes loaded hydroxyapatite–alginate beads with enhanced mechanical properties and sustained drug release ability

et al. 2020

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Single-walled carbon nanotubes (SWCNTs) containing biomaterial with enhanced mechanical properties for the potential orthopedic application were synthesized and investigated. X-ray diffraction and X-ray fluorescence analysis were indications of the formation of calcium-deficient (Ca/P = 1.65) hydroxyapatite (HA) with a small carbonate content under influence of microwave irradiation. The investigated mechanical properties (maximal relative deformation, compressive strength and Young's modulus) of SWCNT loaded HA-alginate composites confirm their dependence on SWCNTs content. The compressive strength of HA-alginate-SWCNT and the HA-alginate control (202 and 159 MPa, respectively) lies within the values characteristic for the cortical bone. The addition of 0.5% SWCNT, in relation to the content of HA, increases the Young's modulus of the HA-alginate-SWCNT (645 MPa) compared to the SWCNT-free HA-alginate sample (563 MPa), and enhances the material shape stability in simulated physiological conditions. Structural modeling of HA-alginate-SWCNT system showed, that physical adsorption of SWCNT into HA-alginate occurs by forming triple complexes stabilized by solvophobic/van der Waals interactions and H-bonds. The high-performance liquid chromatography demonstrated the influence of SWCNTs on the sustained anaesthesinum drug (used as a model drug) release (456 h against 408 h for SWCNTfree sample). Cell culture assay confirmed biocompatibility and stimulation of osteoblast proliferation of 0.05% and 0.5% SWCNT-containing composites during a 3-day cultivation. All these facts may suggest the potential possibility of using the SWCNT-containing materials, based on HA and alginate, for bone tissue engineering.

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Section: Resultsmentioning

confidence: 99%

Single-walled carbon nanotubes loaded hydroxyapatite–alginate beads with enhanced mechanical properties and sustained drug release ability

et al. 2020

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Tracer-based System Dynamic Modeling for Designing a Subsurface Upflow Wetland for Nutrient Removal

Chang

Wanielista

Xuan

2014

Developments in Environmental Modelling

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Migration of volatile organic contaminations (VOCs) through a deforming clay liner

Zhang

Jeng

Barry

et al. 2013

Advances in Water Resources

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Highlights A fully coupled model was proposed for the migration of VOCs in unsaturated landfill liners. Finite deformation of soil was considered in the new model. The transport of gas phase VOCs was found to dominate the migration progress. The temperature gradient can accelerate the breakthrough of VOCs in an unsaturated liner. The mechanical consolidation slowed down the motion of the VOCs.Highlights (for review)

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Cytocompatibility and Mechanical Properties of Hydroxyapatite Composite Reinforced with Multi-Walled Carbon Nanotubes and Bovine Serum Albumin

Cited by 18 publications

References 16 publications

Single-walled carbon nanotubes loaded hydroxyapatite–alginate beads with enhanced mechanical properties and sustained drug release ability

Single-walled carbon nanotubes loaded hydroxyapatite–alginate beads with enhanced mechanical properties and sustained drug release ability

Tracer-based System Dynamic Modeling for Designing a Subsurface Upflow Wetland for Nutrient Removal

Migration of volatile organic contaminations (VOCs) through a deforming clay liner

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