Cytochrome P450 differences in normal and imposex-affected female whelk Buccinum undatum from the open North Sea

Santos, Miguel M.; Hallers-Tjabbes, C.C. ten; Vieira, Maria Natividade; Boon, Jan P.; Porte, Cinta

doi:10.1016/s0141-1136(02)00150-2

Cited by 38 publications

(20 citation statements)

References 7 publications

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“…Organotin compounds have further been reported to inhibit aromatase activity in fish (Sanderson and van den Berg, 2003). Similarly, aromatase activity was decreased in Mytillus galloprovincialis (Morcillo et al, 1998), Baccinum undatum (Morcillo et al, 1999), and Rudipates decussates (Santos et al, 2002) exposed to TBT or inhabiting organotin-polluted sites. However, in many cases, the aromatase activity in non-exposed mussels remained at an extremely low level.…”

Section: Discussionmentioning

confidence: 94%

Sex-related differences in steroid concentrations in the blue mussel (Mytilus edulis trossulus) from the southern Baltic Sea

Zabrzańska

Smolarz

Hallmann

et al. 2015

Comparative Biochemistry and Physiology Part A: Molecular &

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Section: Discussionmentioning

confidence: 94%

Sex-related differences in steroid concentrations in the blue mussel (Mytilus edulis trossulus) from the southern Baltic Sea

Zabrzańska

Smolarz

Hallmann

et al. 2015

Comparative Biochemistry and Physiology Part A: Molecular &

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“…Indeed, TBT has been shown to be an in vitro inhibitor of cytochrome P450 aromatase activity in humans (Cooke 2002;Heidrich et al 2001) and periwinkles (L. littorea, Ronis and Mason 1996). Furthermore, in a comparison of common whelk (Buccinum undatum) females collected from areas of low and high shipping density in the North Sea, cytochrome P450 aromatase activity was significantly higher in normal females from the low shipping density area than in imposex-affected individuals from the high shipping density area (Santos et al 2002). Bettin et al (1996) pursued the possibility that TBT inhibits aromatase by exposing dogwhelks (N. lapillus and H. reticulata) to the steroidal and nonsteroidal aromatase inhibitors, SH 489 and flavone, respectively.…”

Section: How Does Tbt Elevate Testosterone?mentioning

confidence: 98%

Environmental-endocrine control of reproductive maturation in gastropods: implications for the mechanism of tributyltin-induced imposex in prosobranchs

et al. 2009

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Prosobranch snails have been afflicted globally by a condition whereby females develop male sex characteristics, most notably a penis. This condition, known as imposex, has been causally associated with the ubiquitous environmental contaminant tributyltin (TBT). Deduction of the mechanism by which TBT causes imposex has been hampered by the lack of understanding of the normal endocrine regulation of reproductive tract recrudescence in these organisms. We have reviewed the relevant literature on the environmental and endocrine factors that regulate reproductive tract recrudescence, sexual differentiation, and reproduction in gastropods. We provide a cohesive model for the environmental-endocrine regulation of reproduction in these organisms, and use this information to deduce a most likely mechanism by which TBT causes imposex. Photoperiod appears to be the predominant environmental cue that regulates reproductive tract recrudescence. Secondary cues include temperature and nutrition which control the timing of breeding and egg laying. Several hormone products of the central and peripheral nervous systems have been identified that contribute to recrudescence, reproductive behaviors, oocyte maturation and egg laying. Retinoic acid signaling via the retinoid X-receptor (RXR) has shown promise to be a major regulator of reproductive tract recrudescence. Furthermore, TBT has been shown to be a high affinity ligand for the RXR and the RXR ligand 9-cis retinoic acid causes imposex. We propose that TBT causes imposex through the inappropriate activation of this signaling pathway. However, uncertainties remain in our understanding of the environmental-endocrine regulation of reproduction in gastropods. Definitive elucidation of the mechanism of action of TBT awaits resolution of these uncertainties.

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“…ELISA and GC/MS results were comparable and demonstrated significantly higher T concentrations in imposex-affected females than in snails from uncontaminated sites. Santos et al (2002) sampled normal and imposexaffected female Buccinum undatum from the open North Sea at three locations, one with low, and two with high-shipping densities. While levels of cytochrome P450, cytochrome b(5) and NADPH cytochrome c reductase activity did not show differences among groups, CYP19 activity was significantly higher in normal females collected in the low-shipping density area than in imposex-affected animals from highshipping density areas.…”

Section: Aromatase Inhibitionmentioning

confidence: 99%

Endocrine disruption in prosobranch molluscs: evidence and ecological relevance

et al. 2007

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Prosobranch snails represent almost 50% of all recent molluscs, are ubiquitously distributed, play important roles in various ecosystems and exhibit a variety of reproductive modes and life-cycle-strategies. Many of them attain life spans of several years, which in combination with their limited ability to metabolize organic chemicals, may contribute to the fact that prosobranchs constitute one of the most endangered taxonomic groups in aquatic ecosystems. Although it is not yet known to what extent endocrine disrupting chemicals (EDCs) contribute to this situation, the case of tributyltin (TBT) and its population-level impact on prosobranchs demonstrates the general susceptibility of these invertebrates. The existing evidence for comparable population-level effects in prosobranch snails by other androgens, antiandrogens, and estrogens is critically reviewed. The example of TBT demonstrates the difficulty to prove an endocrine mode of action for a given chemical. Although it is generally accepted that TBT causes imposex and intersex in prosobranch snails as a result of endocrine disruption, the detailed biochemical mechanism is still a matter of debate. The strengths and weaknesses of the five competing hypotheses are discussed, together with previously unpublished data. Finally, the ecological relevance of EDC effects on the population and community level and the application of prosobranchs for the assessment of EDCs are addressed.

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Cytochrome P450 differences in normal and imposex-affected female whelk Buccinum undatum from the open North Sea

Cited by 38 publications

References 7 publications

Sex-related differences in steroid concentrations in the blue mussel (Mytilus edulis trossulus) from the southern Baltic Sea

Sex-related differences in steroid concentrations in the blue mussel (Mytilus edulis trossulus) from the southern Baltic Sea

Environmental-endocrine control of reproductive maturation in gastropods: implications for the mechanism of tributyltin-induced imposex in prosobranchs

Endocrine disruption in prosobranch molluscs: evidence and ecological relevance

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