Cytochalasans from the Endophytic Fungus Phomopsis sp. shj2 and Their Antimigratory Activities

Abstract

Cytochalasans from the endophytic fungi featured structure diversity. Our previous study has disclosed that cytochalasans from the endophytic fungus Phomopsis sp. shj2 exhibited an antimigratory effect. Further chemical investigation on Phomopsis sp. shj2 has led to the discovery of seven new cytochalasans (1–7), together with four known ones. Their structures were elucidated through extensive spectroscopic data interpretation and single-crystal X-ray diffraction analysis. Compounds 1–3 and 8–11 exhibited antimigratory effects against MDA-MB-231 in vitro with IC50 values in the range of 1.01−10.42 μM.

LC–PDA–MS/MS-Based Dereplication Guided Isolation of a New Optical Isomer of 19,20-Epoxycytochalasin-N and Its Cytotoxic Activity

“…When the results of the 38 cytochalasin peaks were compared, 22 were found to be previously reported and 16 were discovered to be novel cytochalasins ( Table 1 ). 22 , 23 , 27 , 28 Apparently, without isolation we cannot say which compound is new among the identified peaks of cytochalasins. Furthermore, to characterize the novel compound, purification followed by spectroscopic characterization needs to be performed.…”