CYSTUS052, a polyphenol-rich plant extract, exerts anti-influenza virus activity in mice

Droebner, Karoline; Ehrhardt, Christina; Poetter, Anne; Ludwig, Stephan; Planz, Oliver

doi:10.1016/j.antiviral.2007.04.001

Cited by 113 publications

(87 citation statements)

References 35 publications

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“…Sialic acid staining was performed as previously described (31). Briefly, the staining of sialic acid a-2.6 linked to galactose was performed with Sambucus nigra agglutinin, whereas for sialic acid a-2.3 linked to galactose Maackia amurensis, agglutinin was used (Vector Laboratories, Burlingame, CA).…”

Section: Immunohistologymentioning

confidence: 99%

Highly Pathogenic Influenza Virus Infection of the Thymus Interferes with T Lymphocyte Development

Vogel

Haasbach

Reiling

et al. 2010

The Journal of Immunology

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Highly pathogenic avian influenza viruses (HPAIVs) cause severe disease in humans. Still, the basis for their increased pathogenesis remains unclear. Additionally, the high morbidity in the younger population stays inexplicable, and the recent pandemic H1N1v outbreak in 2009 demonstrated the urgent need for a better understanding about influenza virus infection. In the present study, we demonstrated that HPAIV infection of mice not only led to lung destruction but also to functional damage of the thymus. Moreover, respiratory dendritic cells in the lung functioned as targets for HPAIV infection being able to transport infectious virus from the lung into the thymus. The pandemic H1N1 influenza virus was able to infect respiratory dendritic cells without a proper transport to the thymus. The strong interference of HPAIV with the immune system is especially devastating for the host and can lead to lymphopenia. In summary, from our data, we conclude that highly pathogenic influenza viruses are able to reach the thymus via dendritic cells and to interfere with T lymphocyte development. Moreover, this exceptional mechanism might not only be found in influenza virus infection, but also might be the reason for the increased immune evasion of some new emerging pathogens.

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Section: Immunohistologymentioning

confidence: 99%

Highly Pathogenic Influenza Virus Infection of the Thymus Interferes with T Lymphocyte Development

Vogel

Haasbach

Reiling

et al. 2010

The Journal of Immunology

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“…The respiratory disease caused by influenza A viruses is highly contagious for several animals including humans. Three influenza virus pandemics occurred in the last century, in 1918, 1957, and 1968(Droebner et al, 2007. The first and most devastating of the 20th century pandemic strains emerged in 1918 and caused twenty million deaths worldwide (Beigel and Bray, 2008).…”

Section: Introductionmentioning

confidence: 99%

Screening of Antiviral Medicinal Plants against Avian Influenza Virus H1N1 for Food Safety

Lee¹,

Van²,

Yeul³

et al. 2010

Korean Journal for Food Science of Animal Resources

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Various extracts from 30 medicinal plants were evaluated for their antiviral activity against influenza virus A/Puerto Rico/ 8/34 (H1N1) and cytotoxicity in MDCK cell culture. The plant material (30 g) was extracted with methanol (300 mL) at room temperature for 24 h, after which the methanolic extracts were filtered, evaporated, and subsequently lyophilized. Evaluation of the potential antiviral activity was conducted by a viral replication inhibition test. Among these medicinal plants, Tussilago farfara, Brassica juncea, Prunus armeniaca, Astragalus membranaceus, Patrinia villosa, and Citrus unshiu showed marked antiviral activity against influenza virus A/H1N1 at concentrations ranging from 0.15625 mg/mL to 1.25 mg/mL, 0.3125 mg/mL to 10 mg/mL, 5 mg/mL to 10 mg/mL, 0.625 mg/mL to 10 mg/mL, 0.625 mg/mL to 10 mg/mL, and 0.3125 mg/mL to 5 mg/mL, respectively. The extracts of Tussilago farfara showed cytotoxicity at concentrations greater than 2.5 mg/mL, whereas the other five main extracts showed no cytotoxicity at concentrations of 10 mg/mL. Taken together, the present results indicated that methanolic extracts of the six main plants might be useful for the treatment of influenza virus H1N1.

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“…4-6). LM was assumed to contain antocyanins and proantocyanidins, these being lower polymers than 6-mers, 6) so that these low-molecular-weight compounds seemed not to be essential to the anti-IFV activity of elderberry, although Halliwell et al 25) and Droebner et al 13) have suggested that phenols might exert a direct effect on the virus. Although the contribution of high-molecular-weight compounds to anti-IFV, including the acid polysaccharides derived from elderberry, might be considered as one possibility, further experiments will be required to confirm this notion.…”

Section: Discussionmentioning

confidence: 99%

“…11) Such flavonoids in tea as theaflavin digallate and (À)-epigallocatechin digallate have been reported to act by blocking IFV binding to host cells in vitro. 12,13) Several flavonoids in elderberry have been reported to bind to host cells and prevent IFV infection in vitro.…”

mentioning

confidence: 99%

Anti-Influenza Virus Effects of Elderberry Juice and Its Fractions

Kinoshita

Hayashi

Katayama

et al. 2012

Bioscience, Biotechnology, and Biochemistry

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CYSTUS052, a polyphenol-rich plant extract, exerts anti-influenza virus activity in mice

Cited by 113 publications

References 35 publications

Highly Pathogenic Influenza Virus Infection of the Thymus Interferes with T Lymphocyte Development

Highly Pathogenic Influenza Virus Infection of the Thymus Interferes with T Lymphocyte Development

Screening of Antiviral Medicinal Plants against Avian Influenza Virus H1N1 for Food Safety

Anti-Influenza Virus Effects of Elderberry Juice and Its Fractions

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